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Life-Sustaining Procedures, Palliative Care, and Cost Trends in Dying COPD Patients in U.S. Hospitals: 2005~2014

  • Kim, Sun Jung (Department of Health Administration and Management, Soonchunhyang University) ;
  • Shen, Jay (Department of Health Care Administration and Policy, University of Nevada Las Vegas) ;
  • Ko, Eunjeong (School of Social Work, San Diego State University) ;
  • Kim, Pearl (Department of Health Care Administration and Policy, University of Nevada Las Vegas) ;
  • Lee, Yong-Jae (Department of Family Medicine, Yonsei University College of Medicine) ;
  • Lee, Jae Hoon (Department of Family Medicine, University of Nevada Las Vegas School of Medicine) ;
  • Liu, Xibei (Department of Medicine, University of Arizona College of Medicine) ;
  • Ukken, Johnson (University of Nevada Reno School of Medicine) ;
  • Kioka, Mutsumi (Department of Internal Medicine, University of Nevada Las Vegas School of Medicine) ;
  • Yoo, Ji Won (Department of Internal Medicine, University of Nevada Las Vegas School of Medicine)
  • Received : 2017.11.24
  • Accepted : 2018.02.20
  • Published : 2018.03.01

Abstract

Purpose: Little is known regarding the extent to which dying patients with chronic obstructive pulmonary disease (COPD) receive life-sustaining procedures and palliative care in U.S. hospitals. We examine hospital cost trends and the impact of palliative care utilization on the use of life-sustaining procedures in this population. Methods: Retrospective nationwide cohort analysis was performed using National Inpatient Sample (NIS) data from 2005 and 2014. We examined the receipt of both palliative care and intensive medical procedures, defined as systemic procedures, pulmonary procedures, or surgeries using the International Classification of Diseases, 9th revision (ICD-9-CM). Results: We used compound annual growth rates (CAGR) to determine temporal trends and multilevel multivariate regressions to identify factors associated with hospital cost. Among 77,394,755 hospitalizations, 79,314 patients were examined. The CAGR of hospital cost was 5.83% (P<0.001). The CAGRs of systemic procedures and palliative care were 5.98% and 19.89% respectively (each P<0.001). Systemic procedures, pulmonary procedures, and surgeries were associated with increased hospital cost by 59.04%, 72.00%, 55.26%, respectively (each P<0.001). Palliative care was associated with decreased hospital cost by 28.71% (P<0.001). Conclusion: The volume of systemic procedures is the biggest driver of cost increase although there is a cost-saving effect from greater palliative care utilization.

목적: 미국 병원에서 만성폐색성폐질환으로 사망하는 환자의 연명치료 및 완화의료에 대한 연구는 부족한 현실이다. 이 연구에서는 병원의 의료비 추세 및 완화의료 이용 및 연명치료 이용과의 관련성을 파악하고자 하였다. 방법: 이 연구는 2005~2014년 미국 입원환자 샘플(National Inpatient Sample, NIS)을 후향적 코호트 디자인으로 전환하였으며, ICD-9-CM (International Classification of Diseases, 9th revision) 코드를 활용하여 완화의료 및 집중치료(전신지지치료, 호흡기치료, 호흡기 수술)를 받은 환자를 구분하였다. 결과: 연평균성장률(Compound Annual Growth Rates, CAGR)을 활용하여 병원 의료비의 시계열변화를 확인하였으며, 다수준 다변량 회귀분석을 통해 병원의 의료비에 영향을 미치는 요소를 파악하였다. 전체 77,394,755 입원 건 중 79,314명의 환자가 최종 분석에 사용되었다. 병원 의료비는 연평균성장률이 5.83% (P<0.001)였으며, 전신지지치료와 완화의료의 연평균성장률은 각각 5.98%와 19.89% 였다(모두, P<0.001). 전신지지치료, 호흡기 치료, 호흡기 수술은 각각 59.04%, 72.00%, 55.26%의 병원 의료비 상승에 영향을(모두, P<0.001) 주었던 반면 완화의료는 28.71%의 병원 의료비 감소에 영향을 주었다(P<0.001). 결론: 미국에서 만성폐색성폐질환으로 사망하는 환자 중 전신지지 치료는 병원 의료비 상승의 주된 원인인 반면 완화의료 이용은 비용절감에 영향이 있는 것으로 파악되었다.

Keywords

References

  1. Kaiser Family Foundation. Health status of the Medicare population. A primer on Medicare [Internet]. Menlo Park, CA: Kaiser Family Foundation; 2015 [cited 2017 Oct 17]. Available from: http://files.kff.org/attachment/report-a-primer-on-medicare-key-facts-about-themedicare-program-and-the-people-it-covers.
  2. NIHCM Foundation. Health care's big spenders: the characteristics behind the curve [Internet]. Washington, DC: National Institute for Health Care Management Foundation; 2017 [cited 2017 Oct 17]. Available from: http://www.NIHCM.org.
  3. Barnato AE, Chang CH, Farrell MH, Lave JR, Roberts MS, Angus DC. Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care 2010;48:125-32. https://doi.org/10.1097/MLR.0b013e3181c161e4
  4. Ornstein KA, Aldridge MD, Garrido MM, Gorges R, Bollens-Lund E, Siu AL, et al. The use of life-sustaining procedures in the last month is associated with more depressive symptoms in surviving spouses. J Pain Symptom Manage 2017;53:178-87. https://doi.org/10.1016/j.jpainsymman.2016.08.023
  5. Tschirhart EC, Du Q, Kelley AS. Factors influencing the use of intensive procedures at the end of life. J Am Geriatr Soc 2014;62:2088-94. https://doi.org/10.1111/jgs.13104
  6. Claessens MT, Lynn J, Zhong Z, Desbiens NA, Phillips RS, Wu AW, et al. Dying with lung cancer or chronic obstructive pulmonary disease: insights from SUPPORT. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc 2000;48(5 Suppl):S146-53. https://doi.org/10.1111/j.1532-5415.2000.tb03124.x
  7. Lilly CM, Swami S, Liu X, Riker RR, Badawi O. Five year trends of critical care practice and outcomes. Chest 2017;152:723-35. https://doi.org/10.1016/j.chest.2017.06.050
  8. Kochanek KD, Murphy SL, Xu J, Tejada-Vera B. Deaths: final data for 2014. Natl Vital Stat Rep 2016;65:1-122.
  9. Weingaertner V, Scheve C, Gerdes V, Schwarz-Eywill M, Prenzel R, Bausewein C, et al. Breathlessness, functional status, distress, and palliative care needs over time in patients with advanced chronic obstructive pulmonary disease or lung cancer: a cohort study. J Pain Symptom Manage 2014;48:569-81. https://doi.org/10.1016/j.jpainsymman.2013.11.011
  10. Shin J, Park HY, Lee J. Hospice and palliative care in chronic obstructive pulmonary disease. Korean J Hosp Palliat Care 2017;20:81-92. https://doi.org/10.14475/kjhpc.2017.20.2.81
  11. Habraken JM, ter Riet G, Gore JM, Greenstone MA, Weersink EJ, Bindels PJ, et al. Health-related quality of life in end-stage COPD and lung cancer patients. J Pain Symptom Manage 2009;37:973-81. https://doi.org/10.1016/j.jpainsymman.2008.07.010
  12. Wachterman MW, Pilver C, Smith D, Ersek M, Lipsitz SR, Keating NL. Quality of end-of-life care provided to patients with different serious illnesses. JAMA Intern Med 2016;176:1095-102. https://doi.org/10.1001/jamainternmed.2016.1200
  13. Aslakson RA, Curtis JR, Nelson JE. The changing role of palliative care in the ICU. Crit Care Med 2014;42:2418-28. https://doi.org/10.1097/CCM.0000000000000573
  14. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-smallcell lung cancer. New Engl J Med 2010;363:733-42. https://doi.org/10.1056/NEJMoa1000678
  15. May P, Garrido MM, Cassel JB, Kelley AS, Meier DE, Normand C, et al. Cost analysis of a prospective multi-site cohort study of palliative care consultation teams for adults with advanced cancer: Where do cost-savings come from? Palliat Med 2017;31:378-86. https://doi.org/10.1177/0269216317690098
  16. Rush B, Hertz P, Bond A, McDermid RC, Celi LA. Use of palliative care in patients with end-stage COPD and receiving home oxygen: National trends and barriers to care in the United States. Chest 2017;151:41-6. https://doi.org/10.1016/j.chest.2016.06.023
  17. Brumley R, Enguidanos S, Jamison P, Seitz R, Morgenstern N, Saito S, et al. Increased satisfaction with care and lower costs: results of a randomized trial of in-home palliative care. J Am Geriatr Soc 2007;55:993-1000. https://doi.org/10.1111/j.1532-5415.2007.01234.x
  18. May P, Garrido MM, Cassel JB, Kelley AS, Meier DE, Normand C, et al. Palliative care teams' cost-saving effect is larger for cancer patients with higher numbers of comorbidities. Health Aff (Millwood) 2016;35:44-53. https://doi.org/10.1377/hlthaff.2015.0752
  19. Liu X, Dawod Y, Wonnaparhown A, Shafi A, Doo L, Yoo JW, et al. Effects of hospital palliative care on health, length of stay, and in-hospital mortality across intensive and non-intensive-care units: A systematic review and metaanalysis. Palliat Support Care 2017;15:741-52. https://doi.org/10.1017/S1478951516001164
  20. Gore JM, Brophy CJ, Greenstone MA. How well do we care for patients with end stage chronic obstructive pulmonary disease (COPD)? A comparison of palliative care and quality of life in COPD and lung cancer. Thorax 2000;55:1000-6. https://doi.org/10.1136/thorax.55.12.1000
  21. Bausewein C, Booth S, Gysels M, Kuhnbach R, Haberland B, Higginson IJ. Individual breathlessness trajectories do not match summary trajectories in advanced cancer and chronic obstructive pulmonary disease: results from a longitudinal study. Palliat Med 2010;24:777-86. https://doi.org/10.1177/0269216310378785
  22. Edmonds P, Karlsen S, Khan S, Addington-Hall J. A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliat Med 2001;15:287-95. https://doi.org/10.1191/026921601678320278
  23. Curtis JR. Palliative and end-of-life care for patients with severe COPD. Eur Respir J 2008;32:796-803. https://doi.org/10.1183/09031936.00126107
  24. Vermylen JH, Szmuilowicz E, Kalhan R. Palliative care in COPD: an unmet area for quality improvement. Int J Chron Obstruct Pulmon Dis 2015;10:1543-51.
  25. Schroedl CJ, Yount SE, Szmuilowicz E, Hutchison PJ, Rosenberg SR, Kalhan R. A qualitative study of unmet healthcare needs in chronic obstructive pulmonary disease. A potential role for specialist palliative care? Ann Am Thorac Soc 2014;11:1433-8. https://doi.org/10.1513/AnnalsATS.201404-155BC
  26. Brown CE, Jecker NS, Curtis JR. Inadequate palliative care in chronic lung disease. an issue of health care inequality. Ann Am Thorac Soc 2016;13:311-6. https://doi.org/10.1513/AnnalsATS.201510-666PS
  27. Brown CE, Engelberg RA, Nielsen EL, Curtis JR. Palliative care for patients dying in the intensive care unit with chronic lung disease compared with metastatic cancer. Ann Am Thorac Soc 2016;13:684-9. https://doi.org/10.1513/AnnalsATS.201510-667OC
  28. Au DH, Udris EM, Fihn SD, McDonell MB, Curtis JR. Differences in health care utilization at the end of life among patients with chronic obstructive pulmonary disease and patients with lung cancer. Arch Intern Med 2006;166:326-31. https://doi.org/10.1001/archinte.166.3.326
  29. Teno JM, Gozalo PL, Bynum JP, Leland NE, Miller SC, Morden NE, et al. Change in end-of-life care for Medicare beneficiaries: Site of death, place of care, and health care transitions in 2000, 2005, and 2009. JAMA 2013;309:470-7. https://doi.org/10.1001/jama.2012.207624
  30. Meier DE, Back AL, Berman A, Block SD, Corrigan JM, Morrison RS. A national strategy for palliative care. Health Aff (Millwood) 2017;36: 1265-73. https://doi.org/10.1377/hlthaff.2017.0164
  31. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453-7. https://doi.org/10.1016/S0140-6736(07)61602-X
  32. Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project [Internet]. Rockville, MD: Agency for Healthcare Research and Quality; 2017 [cited 2017 Oct 17]. Available from: http://www.hcup-us.ahrq.gov/db/quality.jsp.
  33. Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project. 2014 Introduction to the NIS [Internet]. Rockville, MD: Agency for Healthcare Research and Quality; 2017 [cited 2017 Oct 17]. Available from: http://www.hcup-us.ahrq.gov/db/nation/nis/NIS_Introduction_2014.jsp.
  34. Barnato AE, Cohen ED, Mistovich KA, Chang CC. Hospital end-of-life treatment intensity among cancer and non-cancer cohorts. J Pain Symptom Manage 2015;49:521-9. https://doi.org/10.1016/j.jpainsymman.2014.06.017
  35. Martin AB, Hartman M, Benson J, Catlin A; National Health Expenditure Accounts Team. Nation health spending in 2014; faster growth driven by coverage expansion and prescription drug spending. Health Aff (Millwood) 2016;35:150-60. https://doi.org/10.1377/hlthaff.2015.1194
  36. Moses H 3rd, Matheson DH, Dorsey ER, George BP, Sadoff D, Yoshimura S. The anatomy of health care in the United States. JAMA 2013; 310:1947-63. https://doi.org/10.1001/jama.2013.281425
  37. Cimasi RJ. Healthcare valuation. Chapter 8. Valuation approaches and methods. Hoboken, New Jersey:Wiley;2014. p. 39-44. (The series in Wiley finance series; vol. 1).
  38. Rao JNK, Scott AJ. A simple method for the analysis of clustered binary data. Biometrics 1992;48:577-85. https://doi.org/10.2307/2532311
  39. Houchens R, Chu B, Steiner C. HCUP methods series. Report #2014-04 [Internet]. Rockville, MD: Agency for Healthcare Research and Quality; 2017 [cited 2017 Oct 18]. Available from: http://www.hcup-us.ahrq.gov/reports/methods/jsp.
  40. Casanova C, de Torres JP, Aguirre-Jaime A, Pinto-Plata V, Marin JM, Cordoba E, et al. The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort. Am J Respir Crit Care Med 2011;184:1015-21. https://doi.org/10.1164/rccm.201105-0831OC
  41. Holst LB, Petersen MW, Hasse N, Perner A, Wetterslev J. Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomized trials with meta-analysis and trial sequential analysis. BMJ 2015;350:h1354. https://doi.org/10.1136/bmj.h1354
  42. Teno JM, Gozalo PL, Mitchell SL, Kuo S, Rhodes RL, Bynum JP, et al. Does feeding tube insertion and its timing improve survival? J Am Geriatr Soc 2012;60:1918-21. https://doi.org/10.1111/j.1532-5415.2012.04148.x
  43. Horton JR, Morrison RS, Capezuti E, Hill J, Lee EJ, Kelley AS. Impact of inpatient palliative care on treatment intensity for patients with serious illness. J Palliat Med 2016;19:936-42. https://doi.org/10.1089/jpm.2015.0240
  44. Yaqoob ZJ, Al-Kindi SG, Zein JG. Trends and disparities in hospice use among patients dying of COPD in the United States. Chest 2017;151: 1183-4. https://doi.org/10.1016/j.chest.2017.02.030
  45. Lopez Bernal J, Cummins S, Gasparrini A. Interrupted time series regression for the evaluation of public health interventions: a tutorial. Int J Epidemiol 2017;46:348-55.
  46. Selecky PA, Eliasson CA, Hall RI, Schneider RF, Varkey B, McCaffree DR, et al. Palliative and end-of-life care for patients with cardiopulmonary diseases: American College of Chest Physicians position statement. Chest 2005;128:3599-610. https://doi.org/10.1378/chest.128.5.3599
  47. Knauft E, Nielsen EL, Engelberg RA, Patrick DL, Curtis JR. Barriers and facilitators to end-of-life care communication for patients with COPD. Chest 2005;127:2188-96. https://doi.org/10.1378/chest.127.6.2188
  48. Center for Medicare and Medicaid Services. Final rule policies for ACP delineated in the CY 2016 PFS final rule (80 Fed. Reg. 70955 through 70959) [Internet]. Baltimore, MD: Center for Medicare and Medicaid Services; 2016 [cited 2017 Oct 17]. Available from: https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/PhysicianFeeSched/PFS-Federal-Regulation-Notices.html.
  49. U.S. Bureau of Labor Statistics. Consumer price index, US average medical care from 2005 to 2014 [Internet]. Washington, DC: U.S. Bureau of Labor Statistics; 2017 [cited 2017 Oct 17]. Available from: http://www.bls/gov/cpi.
  50. Dzingina MD, Reilly CC, Bausewein C, Jolley CJ, Moxham J, McCrone P, et al. Variations in the cost of formal and informal health care for patients with advanced chronic disease and refractory breathlessness: A cross-sectional secondary analysis. Palliat Med 2017;31:369-77. https://doi.org/10.1177/0269216317690994

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