Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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BC200 RNA: An Emerging Therapeutic Target and Diagnostic Marker for Human Cancer

  • Shin, Heegwon (Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Youngmi (Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Meehyein (Virus Research and Testing Group, Korea Research Institute of Chemical Technology) ;
  • Lee, Younghoon (Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST))
  • Received : 2018.11.27
  • Accepted : 2018.11.14
  • Published : 2018.12.31
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Abstract

One of the most interesting findings from genome-wide expression analysis is that a considerable amount of noncoding RNA (ncRNA) is present in the cell. Recent studies have identified diverse biological functions of ncRNAs, which are expressed in a much wider array of forms than proteins. Certain ncRNAs associated with diseases, in particular, have attracted research attention as novel therapeutic targets and diagnostic markers. BC200 RNA, a 200-nucleotide ncRNA originally identified as a neuron-specific transcript, is abnormally over-expressed in several types of cancer tissue. A number of recent studies have suggested mechanisms by which abnormal expression of BC200 RNA contributes to the development of cancer. In this article, we first provide a brief review of a recent progress in identifying functions of BC200 RNA in cancer cells, and then offer examples of other ncRNAs as new therapeutic targets and diagnostic markers for human cancer. Finally, we discuss future directions of studies on BC200 RNA for new cancer treatments.

Keywords

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Fig. 1. Schematic diagram of BC200 RNA.

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Fig. 2. Involvement of BC200 RNA in the genesis and development of cancers.

Table 1. Summary of clinical studies of BC200 RNA in cancer

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