Journal of the Korean Society of Manufacturing Process Engineers (한국기계가공학회지)

The Korean Society of Manufacturing Process Engineers (한국기계가공학회)
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Investigation of Thermal Fusion Bonding and Separation of PMMA Substrates by using Molecular Dynamics Simulations

분자동역학을 이용한 PMMA 평판의 열접합 및 분리에 대한 연구

  • Yi, Taeil (Department of Mechanical Engineering, Kyungnam University)
  • 이태일 (경남대학교 기계공학부)
  • Received : 2018.08.14
  • Accepted : 2018.08.25
  • Published : 2018.10.31
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Abstract

Thermal fusion bonding is a method to enclose open microchannels fabricated on polymer chips for use in lab-on-a-chip (LOC) devices. Polymethyl methacrylate (PMMA) is utilized in various biomedical-microelectromechanical systems (bio-MEMS) applications, such as medical diagnostic kits, biosensors, and drug delivery systems. These applications utilize PMMAs biochemical compatibility, optical transparency, and mold characteristics. In this paper, we elucidate both the conformational entanglement of PMMA molecules at the contact interfacial regime, and the qualitative nature of the thermal fusion bonding phenomena through systematic molecular dynamics simulations.

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References

  1. Manz, A, Graber, N., Widmer, H. M., "Miniaturized total chemical analysis systems: A novel concept for chemical sensing," Sensors and Atuators B: Chemical, Vol. 1, pp. 244-248, 1990. https://doi.org/10.1016/0925-4005(90)80209-I
  2. Harrison, D. J. et al., "Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip", Science, Vol. 261, 895-897, 1993. https://doi.org/10.1126/science.261.5123.895
  3. Reyes, D. R., Iossifidis, D., Auroux, P.-A., Manz, A. "Micro Total Analysis System. 1. Introduction, Theory, and Technology," Analytical Chemistry, Vol. 74, pp 2623-2636, 2002. https://doi.org/10.1021/ac0202435
  4. Thamdrup, L., Klukowska, A., Kristensen, A., "Stretching DNA in polymer nanochannels fabricated by thermal imprint in PMMA," Nanotechnology, Vol. 19, pp. 1-12, 2008.
  5. Park, T., "Thermoplastic Fusion Bonding of UV Modified PMMA Microfluidc Devices," J. Korean Soc. Precis. Eng., Vol. 31, No. 4, pp. 441-449, 2014. https://doi.org/10.7736/KSPE.2014.31.5.441
  6. DeVoe, D.L., Tsao, C.-W., "Bonding of thermoplastic polymer microfluidics", Microfluid Nanofluid, Vol. 6, pp. 1-16, 2009. https://doi.org/10.1007/s10404-008-0361-x
  7. Schmidt, M., Pohle, D. and Rechtenwald, T., "Selective Laser Sintering of PEEK," Annals of the CIRP, Vol. 56, No. 1, pp. 205-208, 2007. https://doi.org/10.1016/j.cirp.2007.05.097
  8. Plimpton, S., "Fast parallel algorithms for short-range molecular dynamics," Journal of Computational Physics, Vol. 117, pp.1-19, 1995. https://doi.org/10.1006/jcph.1995.1039
  9. Humphrey, H., Dalke, A., and Schulten, K., "VMD: Visual Molecular Dynamics," Journal of Molecular Graphics, Vol. 14, pp.33-38, 1996. https://doi.org/10.1016/0263-7855(96)00018-5
  10. Frenkel, D. and Smit, B., Understanding Molecular Simulation - Second Edition, Academic Press., pp. 465-478, 2002
  11. Xia, W., Mishra, S., Keten, S., "Substrate vs. free surface: Competing effects on the glass transition of polymer thin films," Polymer, Vol. 54, pp. 5942-5951, 2013. https://doi.org/10.1016/j.polymer.2013.08.013