The Korean Journal of Pain

  • 제31권1호
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  • Pages.39-42
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  • 2018
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Double blind randomized control trial to evaluate the efficacy of ketoprofen patch to attenuate pain during venous cannulation

  • Kumar, Sanjay (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Sanjeev, Omprakash (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Agarwal, Anil (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Shamshery, Chetna (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Gupta, Rakhi (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences)
  • 투고 : 2017.08.16
  • 심사 : 2017.12.05
  • 발행 : 2018.01.01
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초록

Background: Venipuncture pain is an uncomfortable suffering to the patient. It creates anxiety, fear and dissatisfaction. The ketoprofen transdermal patch is a proven treatment for musculoskeletal and arthritic pain. We planned this study to evaluate the efficacy of the ketoprofen patch to reduce venipuncture pain. Methods: Two hundred adult patients, aged 18-60 years, of either sex, ASA grade I or II, were enrolled. Presuming that therapy would decrease venipuncture pain by 30%, a power calculation with ${\alpha}=0.05$ and ${\beta}=0.80$ required enrollment of at least 24 patients into each group. However, 100 patients in each group were recruited. Group I (Control) received a placebo patch; Group II (Ketoprofen) received a 20 mg ketoprofen patch. A selected vein on the dorsum of the patient's non-dominant hand was cannulated with 18 g intravenous cannula 1 h after the application of the respective patch. Assessment of pain was done by a 10 cm visual analogue scale (VAS) of 0-10, where 0 depicts "no pain" and 10 is "the worst imaginable pain". The venipuncture site was assessed for the presence of skin erythema, swelling and rashes at 12 h, 24 h and at the time of decannulation. Results: Incidence of pain was 100% (94/94) in the control group as compared to 93% (85/91) in the ketoprofen group. The severity of the venipuncture pain was 6 (2) and 2 (2) for control and ketoprofen groups respectively (P < 0.05). Conclusions: Application of a ketoprofen patch at the proposed site of venipuncture one hour before the attempt is effective and safe for attenuating venipuncture pain.

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참고문헌

  1. Keane TK, Hennis PJ, Bink-Boelkens MT. Non-drug related asystole associated with anaesthetic induction. Anaesthesia 1991; 46: 38-9. https://doi.org/10.1111/j.1365-2044.1991.tb09313.x
  2. Hart PS, Yanny W. Needle phobia and malignant vasovagal syndrome. Anaesthesia 1998; 53: 1002-4. https://doi.org/10.1046/j.1365-2044.1998.00570.x
  3. Lal MK, McClelland J, Phillips J, Taub NA, Beattie RM. Comparison of EMLA cream versus placebo in children receiving distraction therapy for venepuncture. Acta Paediatr 2001; 90: 154-9. https://doi.org/10.1111/j.1651-2227.2001.tb00277.x
  4. Agarwal A, Gautam S, Gupta D, Singh U. Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain. Can J Anaesth 2007; 54: 196-200. https://doi.org/10.1007/BF03022640
  5. Smith AJ, Eggers KA, Stacey MR, Power I. Topical ibuprofen for skin analgesia prior to venepuncture. Anaesthesia 1996; 51: 495-7. https://doi.org/10.1111/j.1365-2044.1996.tb07801.x
  6. Agarwal A, Yadav G, Gupta D, Tandon M, Dhiraaj S, Singh PK. Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study. Anaesth Intensive Care 2007; 35: 726-9.
  7. Usichenko TI, Pavlovic D, Foellner S, Wendt M. Reducing venipuncture pain by a cough trick: a randomized crossover volunteer study. Anesth Analg 2004; 98: 343-5.
  8. Agarwal A, Sinha PK, Tandon M, Dhiraaj S, Singh U. Evaluating the efficacy of the valsalva maneuver on venous cannulation pain: a prospective, randomized study. Anesth Analg 2005; 101: 1230-2. https://doi.org/10.1213/01.ane.0000167270.15047.49
  9. Park HJ, Moon DE. Pharmacologic management of chronic pain. Korean J Pain 2010; 23: 99-108. https://doi.org/10.3344/kjp.2010.23.2.99
  10. Tripathi KD. Essentials of medical pharmacology. 6th ed. New Delhi, Jaypee Brothers. 2008, pp 192-3.
  11. Massey T, Derry S, Moore RA, McQuay HJ. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev 2010: CD007402.
  12. Komatsu T, Sakurada T. Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe. Eur J Pharm Sci 2012; 47: 890-5. https://doi.org/10.1016/j.ejps.2012.08.016
  13. Adachi H, Ioppolo F, Paoloni M, Santilli V. Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch: a new patch formulation. Eur Rev Med Pharmacol Sci 2011; 15: 823-30.

피인용 문헌

  1. Transdermal Ketoprofen Patch in Comparison to Eutectic Mixture of Local Anesthetic Cream and Subcutaneous Lidocaine to Control Pain Due to Venous Cannulation vol.12, pp.4, 2018, https://doi.org/10.4103/aer.aer_166_18