The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Double blind randomized control trial to evaluate the efficacy of ketoprofen patch to attenuate pain during venous cannulation

  • Kumar, Sanjay (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Sanjeev, Omprakash (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Agarwal, Anil (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Shamshery, Chetna (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences) ;
  • Gupta, Rakhi (Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences)
  • Received : 2017.08.16
  • Accepted : 2017.12.05
  • Published : 2018.01.01
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Abstract

Background: Venipuncture pain is an uncomfortable suffering to the patient. It creates anxiety, fear and dissatisfaction. The ketoprofen transdermal patch is a proven treatment for musculoskeletal and arthritic pain. We planned this study to evaluate the efficacy of the ketoprofen patch to reduce venipuncture pain. Methods: Two hundred adult patients, aged 18-60 years, of either sex, ASA grade I or II, were enrolled. Presuming that therapy would decrease venipuncture pain by 30%, a power calculation with ${\alpha}=0.05$ and ${\beta}=0.80$ required enrollment of at least 24 patients into each group. However, 100 patients in each group were recruited. Group I (Control) received a placebo patch; Group II (Ketoprofen) received a 20 mg ketoprofen patch. A selected vein on the dorsum of the patient's non-dominant hand was cannulated with 18 g intravenous cannula 1 h after the application of the respective patch. Assessment of pain was done by a 10 cm visual analogue scale (VAS) of 0-10, where 0 depicts "no pain" and 10 is "the worst imaginable pain". The venipuncture site was assessed for the presence of skin erythema, swelling and rashes at 12 h, 24 h and at the time of decannulation. Results: Incidence of pain was 100% (94/94) in the control group as compared to 93% (85/91) in the ketoprofen group. The severity of the venipuncture pain was 6 (2) and 2 (2) for control and ketoprofen groups respectively (P < 0.05). Conclusions: Application of a ketoprofen patch at the proposed site of venipuncture one hour before the attempt is effective and safe for attenuating venipuncture pain.

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References

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Cited by

  1. Transdermal Ketoprofen Patch in Comparison to Eutectic Mixture of Local Anesthetic Cream and Subcutaneous Lidocaine to Control Pain Due to Venous Cannulation vol.12, pp.4, 2018, https://doi.org/10.4103/aer.aer_166_18