Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Serum micronutrients levels and clinical features of elderly asthmatics

노인 천식에서 혈중 미량 영양소와 임상 양상의 연관성 분석

  • Lee, So-Hee (Departement of Internal Medicine, Seoul National University College of Medicine) ;
  • Song, Woo-Jung (Departement of Internal Medicine, Seoul National University College of Medicine) ;
  • Park, Heung-Woo (Departement of Internal Medicine, Seoul National University College of Medicine) ;
  • Kim, Sae-Hoon (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Park, Hye-Kyung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kwon, Yong Eun (Department of Internal Medicine, Chosun University Medical School) ;
  • Kim, Tae-Bum (Department of Allergy and Clinical Immunology, Asan Medical Center) ;
  • Lee, Byung-Jae (Department of Internal Medicine, Samsung Medical Center) ;
  • Jee, Young-Koo (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Choi, Byoung Whui (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Cho, Sang-Heon (Departement of Internal Medicine, Seoul National University College of Medicine) ;
  • Kim, Sun Sin (Departement of Internal Medicine, Seoul National University College of Medicine)
  • 이소희 (서울대학교병원 알레르기내과) ;
  • 송우정 (서울대학교병원 알레르기내과) ;
  • 박흥우 (서울대학교병원 알레르기내과) ;
  • 김세훈 (분당서울대학교병원 내과) ;
  • 박혜경 (부산대병원 내과) ;
  • 김상헌 (한양대병원 내과) ;
  • 권용은 (조선대병원 내과) ;
  • 김태범 (서울아산병원 내과) ;
  • 이병재 (삼성서울병원 내과) ;
  • 지영구 (단국대병원 내과) ;
  • 최병휘 (중앙대병원 내과) ;
  • 조상헌 (서울대학교병원 알레르기내과) ;
  • 김선신 (서울대학교병원 알레르기내과)
  • Published : 20170000
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Abstract

Purpose: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics. Methods: A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B12, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated. Results: Positive correlations with significance among serum levels of vitamin B12, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B12 and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se. Conclusion: Serum levels of micronutrients, such as vitamin D, vitamin B12, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further.

Keywords