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Sarcopenia and Smoking: Systematic Review and Meta-analysis

근감소증과 흡연: 체계적 문헌고찰 및 메타분석

  • Kim, Su Kyung (Department of Pharmacology, School of Medicine, Keimyung University) ;
  • Shin, Yeong Hee (College of Nursing, Keimyung University.Research Institute for Nursing Science) ;
  • Kim, Gaeun (College of Nursing, Keimyung University.Research Institute for Nursing Science)
  • 김수경 (계명대학교 의과대학 약리학교실) ;
  • 신영희 (계명대학교 간호대학.간호과학연구소) ;
  • 김가은 (계명대학교 간호대학.간호과학연구소)
  • Received : 2017.06.08
  • Accepted : 2017.08.17
  • Published : 2017.08.31
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Abstract

This study performed meta-analysis of published articles to examine the relationship between sarcopenia and smoking. We searched the PubMed, EMBASE, Cochrane library, and RISS database sup to January 2017 using search terms such as sarcopenia AND (smoking OR tobacco OR cigarette). A total of 25 articles were included in the analysis (seven cohort studies and 18 cross-sectional studies). Incidence of sarcopenia in smokers and non-smokers was analyzed by the random effects model. Incidence of sarcopenia was OR 1.49 (95% CI 1.21, 1.84, p<.001, I2 = 88.20%), Asian (OR 1.28, 95% CI 0.91, 1.78, p=0.150, I2=85.32%), and Western (OR 1.65, 95% CI 1.25, 2.17, p<.001, I2=91.08%), Western smokers showed a significantly higher incidence of sarcopenia:males and females with OR 1.25(95% CI 1.11, 1.40, p<.001, 12=87.4%) and 1.80(95% CI 0.98, 3.30, p=.057, 12=89.1 %) respectively. Male smokers showed significantly higher incidence of sarcopenia. Based on the results of the study, smoking in Western males is related to sarcopenia. However, since the criteria for the diagnosis of sarcopenia and the criteria for smoking were different, cumulative individual clinical studies applying uniform assessment for the evaluation of sarcopenia and smoking status are needed in the future.

본 연구는 근감소증과 흡연과의 관계를 체계적으로 검토하기 위해 메타분석을 하였다. PubMed, EMBASE, Cochrane library등의 국외 Database와 RlSS등의 국내 Database에서 (sarcopenia AND (smok?ng OR tobacco OR cigarette)) 등의 검색어로 2017년 1월까지의 문헌을 검색하였다. 문헌검색결과 총 25편(Cohort연구 7편, cross sectional연구 18편)의 문헌이 분석에 포함되었고, 흡연군과 비흡연군 간의 근감소증 발생률을 random effects model로 분석한 결과, 근감소증 발생률은 전체 OR 1.49(95% CI 1.21, 1.84, P = 0.000, $I^2=88.20%$이었다. 인종별로는 동양인(OR 1.28(95% CI 0.91, 1.78, P = 0.150, $I^2=85.32%$)), 서양인(OR 1.66(95% CI 1.25, 2.17, P = 0.000, $I^2=91.08%$))으로 서양인 흡연자에서의 근감소증 발생률이 통계적으로 유의하게 높았으며, 성별로는 남성과 여성 각각 OR 1.25(95% CI 1.11, 1.40, P = 0.000, $I^2=87.4%$), 1.80(95% CI 0.98, 3.30, P = 0.057, $I^2=89.11%$)로 남성에서 근감소증 발생률이 통계적으로 유의하게 높았다. 본 연구결과를 토대로 서양인 남성에서 흡연은 근감소에 영향을 마치는 것으로 판단된다. 그러나 근감소증 진단기준, 흡연에 대한 판단 기준이 개별연구마다 상이하므로 향후 근감소증 기준 및 흡연상태 평가에 대한 획일적 평가방법이 적용된 개별 임상연구의 누적이 필요한 것으로 사료된다.

Keywords

Acknowledgement

Supported by : 한국연구재단

References

  1. M. Di Monaco, "Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture", Archives of Gerontology and Geriatrics, vol. 52, pp. 71-74, 2011. DOI: http://dx.doi.org/10.1016/j.archger.2010.02.002
  2. M. Visser, L. A. Schaap, "Consequences of sarcopenia", Clinics in Geriatric Medicine, vol. 27. no. 3, pp. 387-399, 2011. DOI: http://dx.doi.org/10.1016/j.cger.2011.03.006
  3. Tda. S. Alexandre, Y. A. Duarte, J. L. Santos, R. Wong, M. L. Lebrao, "Sarcopenia according to the European Working Group on Sarcopenia in Older People (EWGSOP) versus dynapenia as a risk factor for mortality in the elderly", The Journal of Nutrition, Health & Aging, vol. 18, pp. 547-553, 2014. DOI: https://doi.org/10.1007/s12603-014-0465-9
  4. J. E. Morley, S. D. Anker, S. von Haehling, "Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology", Journal of Cachexia, Sarcopenia and Muscle, vol. 5, no. 4, pp. 253-259, 2014. DOI: http://dx.doi.org/10.1007/s13539-014-0161-y
  5. J. A. Batsis, T. A. Mackenzie, L. K. Barre, F. Lopez-Jimenez, S. J. Bartels, "Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III", European Journal of Clinical Nutrition, vol. 68. no. 9, pp. 1001-1007, 2014. DOI: http://dx.doi.org/10.1038/ejcn.2014.117
  6. T. S. Alexandre, Y. A. Duarte, J. L. Santos, R. Wong, M. L. Lebrao, "Sarcopenia according to the European Working Group on Sarcopenia in Older People(EWGSOP) versus dynapenia as a risk factor for mortality in the elderly", The Journal of Nutrition, health & aging, vol. 18. no. 8, pp. 751-756, 2014. DOI: http://dx.doi.org/10.1007/s12603-014-0450-3
  7. I. H. Rosenberg, "Summary comments", The American Journal of Clinical Nutrition, vol. 50. no. 5, pp. 1231-1233, 1989. https://doi.org/10.1093/ajcn/50.5.1231
  8. R. N. Baumgartner, K. M. Koehler, D. Gallagher, D, L. Romero, S. B. Heymsfield, R. R. Ross, "Epidemiology of sarcopenia among the elderly in New Mexico", American Journal of Epidemiology, vol. 147. no. 8, pp. 755-763, 1998. DOI: https://doi.org/10.1093/oxfordjournals.aje.a009520
  9. I. Janssen, S. B. Heymsfield, Z. M. Wang, R. Ross, "Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr", Journal of Applied Physiology, vol. 89. no. 1, pp. 81-88, 2000. https://doi.org/10.1152/jappl.2000.89.1.81
  10. A. B. Newman, V. Kupelian, M. Visser, E. Simonsick, B. Goodpaster, M. Nevitt, "Sarcopenia: alternative definitions and associations with lower extremity function", Journal of the American Geriatrics Society, vol. 51. no. 11, pp. 1602-1609, 2003. DOI: https://doi.org/10.1046/j.1532-5415.2003.51534.x
  11. R. A. Fielding, B. Vellas, W. J. Evans, S. Bhasin, J. E. Morley, A. B. Newman, "Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia", Journal of the American Medical Directors Association, vol. 12. no. 4, pp. 249-256, 2011. DOI: http://dx.doi.org/10.1016/j.jamda.2011.01.003
  12. A. J. Cruz-Jentoft, J. P. Baeyens, J. M. Bauer, Y. Boirie, T. Cederholm, F. Landi, "Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People", Age and Ageing, vol. 39. no. 4, pp. 412-423, 2010. DOI: http://dx.doi.org/10.1093/ageing/afq034
  13. E. M. Castillo, D. Goodman, Kritz-Silverstein, D. J. Morton, D. L. Wingard, E. Barrett-Connor, "Sarcopenia in elderly men and women: the Rancho Bernardo study", American Journal of Preventive Medicine, vol. 25. no. 3, pp. 226-231, 2003. DOI: https://doi.org/10.1016/S0749-3797(03)00197-1
  14. J. S. Lee, T. W. Auyeung, T. Kwok, E. M. Lau, P. C. Leung, J. Woo, "Associated factors nd health impact of sarcopenia in older chinese men and women: a cross-sectional study", Gerontology, vol. 53. no. 6, pp. 404-410, 2007. DOI: http://dx.doi.org/10.1159/000107355
  15. S. Clavel, A. S. Coldefy, E. Kurkdjian, J. Salles, I. Margaritis, B. Derijard, "Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle", Mechanisms of Ageing and Development, vol. 127. no. 10, pp. 794-801, 2006. DOI: http://dx.doi.org/10.1016/j.mad.2006.07.005
  16. M. Altun, H. C. Besche, H. S. Overkleeft, R. Piccirillo, M. J. Edelmann, B. M. Kessler, et al. "Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway", Journal of Biological Chemistry, vol. 285. no. 51, pp. 39597-39608, 2010. DOI: http://dx.doi.org/10.1074/jbc.M110.129718
  17. D. Cai, K. K. Lee, M. Li, M. K. Tang, K. M. Chan, "Ubiquitin expression is up-regulated in human and rat skeletal muscles during aging", Archives of Biochemistry and Biophysics, vol. 425. no. 1, pp. 42-50, 2004. DOI: http://dx.doi.org/10.1016/j.abb.2004.02.027
  18. D. Raue, D. Slivka, B. Jemiolo, C. Hollon, S. Trappe, "Proteolytic gene expression differs at rest and after resistance exercise between young and old women", Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, vol. 62. no. 12, pp. 1407-1412, 2007. DOI: https://doi.org/10.1093/gerona/62.12.1407
  19. A. J. Murton, D. Constantin, P. L. Greenhaff, "The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy", Biochimica et Biophysica Acta, vol. 1782. no. 12, pp. 730-743, 2008. DOI: http://dx.doi.org/10.1016/j.bbadis.2008.10.011
  20. O. Rom, A. Z. Reznick, "The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass", Free Radical Biology and Medicine, vol. 98, pp. 218-230, 2016. DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2015.12.03
  21. M. Steffl, R. W. Bohannon, M. Petr, E. Kohlikova, I. Holmerova, "Relation between cigarette smoking and sarcopenia: meta-analysis", Physiological Research, vol. 64. no. 3, pp. 419-426, 2015.
  22. T. Akune, S. Muraki, H. Oka, S. Tanaka, H. Kawaguchi, K. Nakamura, "Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study", Osteoporosis International, vol. 25. no. 3, pp. 1081-1088, 2014. DOI: http://dx.doi.org/10.1007/s00198-013-2550-z
  23. T. S. Alexandre, Y. A. Duarte, J. L. Santos, R. Wong, M. L. Lebrao, "Prevalence and associated factors of sarcopenia among elderly in Brazil: findings from the SABE study", The Journal of Nutrition, Health & Aging, vol. 18. no. 3, pp. 284-290, 2014. DOI: http://dx.doi.org/10.1007/s12603-013-0413-0
  24. J. A. Batsis, T. A. Mackenzie, J. D. Jones, F. Lopez-Jimenez, S. J. Bartels, "Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999-2004 National Health and Nutrition Examination Survey", Clinical Nutrition, vol. 35. no. 6, pp. 1472-1483, 2014. DOI: http://dx.doi.org/10.1016/j.clnu.2016.03.028
  25. K. M. Beavers, D. P. Beavers, M. C. Serra, R. G. Bowden, R. L. Wilson, "Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III", The Journal of Nutrition, Health & Aging, vol. 13. no. 3, pp. 177-182, 2009. DOI: https://doi.org/10.1007/s12603-009-0054-5
  26. S. O. Chin, S. Y. Rhee, S. Chon, Y. C. Hwang, I. K. Jeong, S. Oh, "Sarcopenia is independently associated with cardiovascular disease in older Korean adults: the Korea National Health and Nutrition Examination Survey (KNHANES) from 2009", PloS One, vol. 8. no. 3, pp. e60119, 2013. DOI: http://dx.doi.org/10.1371/journal.pone.0060119
  27. H. W. Chung, "Association of coffee consumption with sarcopenia in Korean elderly men: using the Kores national Health and Nutrition Examination Survey, 2009-2011", Thesis for Degree of Master. Jeju National University Graduate School, Department of Medicine. 2016.
  28. D. S. Domiciano, C. P. Figueiredo, J. B. Lopes, V. F. Caparbo, L. Takayama, P. R. Menezes, "Discriminating sarcopenia in community-dwelling older women with high frequency of overweight/obesity: the Sao Paulo Ageing & Health Study (SPAH)", Osteoporosis International, vol. 24. no. 2, pp. 595-603, 2013. DOI: http://dx.doi.org/10.1007/s00198-012-2002-1
  29. C. P. Figueiredo, D. S. Domiciano, J. B. Lopes, V. F. Caparbo, M. Scazufca, E. Bonfa, "Prevalence of sarcopenia and associated risk factors by two diagnostic criteria in community-dwelling older men: the Sao Paulo Ageing & Health Study (SPAH)", Osteoporosis International, vol. 25. no. 2, pp. 589-596, 2014. DOI: http://dx.doi.org/10.1007/s00198-013-2455-x
  30. M. J. Goodman, S. R. Ghate, P. Mavros, S. Sen, R. L. Marcus, E. Joy, "Development of a practical screening tool to predict low muscle mass using NHANES 1999-2004", Journal of Cachexia, Sarcopenia and muscle, vol. 4. no. 3, pp. 187-197, 2013. DOI: http://dx.doi.org/10.1007/s13539-013-0107-9
  31. P. Han, J. Zhao, Q. Guo, J. Wang, W. Zhang, S. Shen, "Incidence, Risk Factors, and the Protective Effect of High Body Mass Index against Sarcopenia in Suburb-Dwelling Elderly Chinese Populations", The Journal of Nutrition, Health & Aging, vol. 20. no. 10, pp. 1056-1060, 2016. DOI: http://dx.doi.org/10.1007/s12603-016-0704-3
  32. Y. C. Hwang, I. J. Cho, I. K. Jeong, K. J. Ahn, H. Y. Chung, "Differential association between sarcopenia and metabolic phenotype in Korean young and older adults with and without obesity", Obesity, vol. 25. no. 1, pp. 244-251, 2017. DOI: http://dx.doi.org/10.1002/oby.21694
  33. Y. K. Jeon, M. J. Shin, M. H. Kim, J. H. Mok, S. S. Kim, B. H. Kim, "Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011", Osteoporosis International, vol. 26. no. 10, pp. 2423-2429, 2015. DOI: http://dx.doi.org/10.1007/s00198-015-3152-8
  34. E. Y. Kim, K. Kim, Y. S. Kim, H. K. Ahn, Y. M. Jeong, J. H. Kim, W. J. Choi, "Prevalence of and Factors Associated with Sarcopenia in Korean Cancer Survivors: Based on Data Obtained by the Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2011", Nutrition and Cancer, vol. 69. no. 3, pp. 394-401, 2017. DOI: http://dx.doi.org/10.1080/01635581.2017.1267776
  35. S. H. Kim, T. H. Kim, H. J. Hwang, "The relationship of physical activity (PA) and walking with sarcopenia in Korean males aged 60 years and older using the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV-2,3), 2008-2009", Archives of Gerontology and Geriatrics, vol. 56. no. 3, pp. 472-477, 2013. DOI: http://dx.doi.org/10.1016/j.archger.2012.12.009
  36. F. Landi, R. Liperoti, A. Russo, S. Giovannini, M. Tosato, E. Capoluongo, "Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study", Clinical Nutrition, vol. 31. no. 5, pp. 652-658, 2012. DOI: http://dx.doi.org/10.1016/j.clnu.2012.02.007
  37. E. M. Lau, H. S. Lynn, J. W. Woo, T. C. Kwok, L. J. Melton, "Prevalence of and risk factors for sarcopenia in elderly Chinese men and women", The journals of gerontology. Series A, Biological Sciences and Medical Sciences, vol. 60. no. 2, pp. 213-216, 2005. DOI: https://doi.org/10.1093/gerona/60.2.213
  38. S. K. Lee, J. A. Lee, J. Y. Kim, Y. Z. Kim, H. S. Park, "The Risk Factors of Sarcopenia among Korean Elderly Men: Based on 2009 Korean National Health and Nutrition Examination Survey Data", Korean Journal of Obesity, vol. 23. no. 1, pp. 29-31, 2014. DOI: https://doi.org/10.7570/kjo.2014.23.1.23
  39. C. C. Lin, W. Y. Lin, N. H. Meng, C. I. Li, C. S. Liu, C. H. Lin, "Sarcopenia prevalence and associated factors in an elderly Taiwanese metropolitan population", Journal of the American Geriatrics Society, vol. 61. no. 3, pp. 459-462, 2013. DOI: http://dx.doi.org/10.1111/jgs.12129
  40. L. K. Liu, W. J. Lee, L. Y. Chen, A. C. Hwang, M. H. Lin, L. N. Peng, "Sarcopenia, and its association with cardiometabolic and functional characteristics in Taiwan: results from I-Lan Longitudinal Aging Study", Geriatrics & Gerontology International, vol. 14. no. 1, pp. 36-45, 2014. DOI: http://dx.doi.org/10.1111/ggi.12208
  41. S. Park, J. O. Ham, B. K. Lee, "A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men", Clinical Nutrition, vol. 33. no. 5, pp. 900-905, 2014. DOI: http://dx.doi.org/10.1016/j.clnu.2013.09.016
  42. Y. Rolland, V. Lauwers-Cances, C. Cristini, G. Abellan van Kan, I. Janssen, J. E. Morley, "Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS Study", The American Journal of Clinical Nutrition, vol. 89. no. 6, pp. 1895-1900, 2009. DOI: http://dx.doi.org/10.3945/ajcn.2008.26950
  43. D. L. Vetrano, F. Landi, S. Volpato, A. Corsonello, E. Meloni, R. Bernabei, "Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care wards: results from the CRIME study", The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 69. no. 9, pp. 1154-1161, 2014. DOI: http://dx.doi.org/10.1093/gerona/glu034
  44. S. Volpato, L. Bianchi, A. Cherubini, F. Landi, M. Maggio, E. Savino, "Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm", The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 69. no. 4, pp. 438-446, 2013. DOI: https://doi.org/10.1093/gerona/glt149
  45. C. H. Wu, K. T. Chen, M. T. Hou, Y. F. Chang, C. S. Chang, P. Y. Liu, "Prevalence and associated factors of sarcopenia and severe sarcopenia in older Taiwanese living in rural community: the Tianliao Old People study 04", Geriatrics and Gerontology International, vol. 14. no. 1, pp. 69-75, 2014. DOI: http://dx.doi.org/10.1111/ggi.12233
  46. S. Lim, J. H. Kim, J. W. Yoon, S. M. Kang, S. H. Choi, Y. J. Park, "Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA)", Diabetes Care, vol. 33. no. 7, pp. 1652-1654, 2010. DOI: http://dx.doi.org/10.2337/dc10-0107
  47. S. B. Heymsfield, R. Smith, M. Aulet, B. Bensen, S. Lichtman, J. Wang, "Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry", American Journal of Clinical Nutrition, vol. 52. no. 2, pp. 214-218, 1990. https://doi.org/10.1093/ajcn/52.2.214
  48. R. N. Foley, C. Wang, A. Ishani, A. J. Collins, A. M. Murray, "Kidney function and sarcopenia in the United States general population: NHANES III", American Journal of Nephrology, vol. 27. no. 3, pp. 279-286, 2007. DOI: http://dx.doi.org/10.1159/000101827
  49. J. H. Chung, H. J. Hwang, C. H. Han, B. S. Son, D. H. Kim, M. S. Park, "Association between sarcopenia and metabolic syndrome in chronic obstructive pulmonary disease: the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011", Journal of Chronic Obstructive Pulmonary Disease, vol. 12. no. 1, pp. 82-89, 2015. DOI: https://doi.org/10.3109/15412555.2014.908835
  50. R. N. Baumgartner, "Body composition in healthy aging", Annals of the New York Academy of Sciences, vol. 904, pp. 437-448, 2000. DOI: https://doi.org/10.1111/j.1749-6632.2000.tb06498.x
  51. J. Lim, G. Kim, Y. Shin, "Effects for kangaroo care: systematic review and meta analysis", Journal of the Korea Academia-Industrial cooperation Society, vol. 17. no. 3, pp. 599-610, 2016. DOI: http://dx.doi.org/10.5762/KAIS.2016.17.3.599
  52. H. H. Shin, Y. H. Shin, G. Kim, "Effect of cognitive behavioral therapy (CBT) for perinatal depression: A systematic review and meta analysis", Journal of the Korea Academia-Industrial cooperation Society, vol. 17. no. 11, pp. 271-284, 2016. DOI: http://dx.doi.org/10.5762/KAIS.2016.17.11.271
  53. Y. Kim, H. S. Choi, J. H. Han, J. Kim, G. Kim, "Aquatic exercise for the treatment of knee osteoarthritis: systematic review and meta analysis", Journal of the Korea Academia-Industrial cooperation Society, vol. 16. no. 9, pp. 6099-6111, 2015. DOI: http://dx.doi.org/10.5762/KAIS.2015.16.9.6099