Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Methodological approaches for the clinical routine production of [11C]raclopride

  • Cheong, Il-koo (Gachon Advanced Institute for Health Science and Technology, Graduate School, Gachon University) ;
  • Lee, Jihye (Neuroscience Research Institute, Gachon University) ;
  • Lee, Sang-Yoon (Gachon Advanced Institute for Health Science and Technology, Graduate School, Gachon University)
  • Received : 2017.06.05
  • Accepted : 2017.06.22
  • Published : 2017.06.30
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Abstract

In carbon-11 labeling, $[^{11}C]$methyltriflate (methyltrifluoromethanesulfonate, MeOTf) is the most widely used through mild reaction condition with high yield. Strong inorganic bases, KOH, NaH and so on, were chosen to activate precursors that have phenolic alcohol as a nucleophilic moiety, because of its poor nucleophilicity. However, these catalyst can also react with radioactive intermediate, $[^{11}C]$MeOTf to afford side products. We will briefly discuss the history of the effort to increase the yield of $[^{11}C]$raclopride and suggest the alternate method for better radiochemical yield and consistency.

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References

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