The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Two Case Studies of the Use of Oreong-san for a Chronic Subdural Hematoma

만성 경막하 혈종(Chronic subdural hematoma, CSDH)에 대한 오령산 증례보고 2례

  • Jeong, Yun-kyeong (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Kim, Su-bin (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Yang, Jung-yun (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Moon, Sang-kwan (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Jung, Woo-sang (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Kwon, Seung-won (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University) ;
  • Cho, Ki-ho (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
  • 정윤경 (경희대학교 대학원 임상한의학과) ;
  • 김수빈 (경희대학교 대학원 임상한의학과) ;
  • 양정윤 (경희대학교 대학원 임상한의학과) ;
  • 문상관 (경희대학교 대학원 임상한의학과) ;
  • 정우상 (경희대학교 대학원 임상한의학과) ;
  • 권승원 (경희대학교 대학원 임상한의학과) ;
  • 조기호 (경희대학교 대학원 임상한의학과)
  • Received : 2017.03.27
  • Accepted : 2017.05.25
  • Published : 2017.05.30
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Abstract

We describe the cases of two patients with chronic subdural hematomas who were treated with Oreong-san. The patients' symptoms improved, as verified by brain computed tomography imaging. Oreong-san may control membrane permeability by inhibiting the aquaporin channel of the outer membrane of a hematoma. We speculate that hydrostatic modulation is a key mechanism underlying the effectiveness of Oreong-san in the treatment of subdural hematomas.

Keywords

References

  1. Thotakura AK, Marabathina NR. Nonsurgical treatment of chronic subdural hematoma with steroids. World neurosurgery 2015;84(6):1968-72. https://doi.org/10.1016/j.wneu.2015.08.044
  2. Voelker JL. Nonoperative treatment of chronic subdural hematoma. Neurosurg Clin N Am 2000 ;11(3):507-13.
  3. Weigei R, Hohenstein A, Schlickum L, Weiss C, Schilling L. Angiotensin converting enzyme inhibition for arterial hypertension reduces the risk of recurrence in patients with chronic subdural hematoma possibly by an anti-angiogenic mechanism. Neurosurgery 2007;61(4):788-93. https://doi.org/10.1227/01.NEU.0000298907.56012.E8
  4. Ambrosetto C. Post-traumatic subdural hematoma. Further observations on nonsurgical treatment. Arch Neurol 1962;6(4):287-92. https://doi.org/10.1001/archneur.1962.00450220029005
  5. Suzuki J, Takaku A. Nonsurgical treatment of chronic subdural hematoma. J Neurosurg 1970; 33(5):548-53. https://doi.org/10.3171/jns.1970.33.5.0548
  6. Yang W, Huang J. Chronic Subdural Hematoma: Epidemiology and Natural History. Neurosurgery Clinics of North America 2017 Apr;28(2):205-10. https://doi.org/10.1016/j.nec.2016.11.002
  7. Kurita T, Nakamura K, Tabuchi M, Orita M, Ooshima K, Higashino H. Effects of Goreisan: a traditional Japanese kampo medicine, on aquaporin 1,2,3,4 and V2R mRNA expression in rat kidney and forebrain. J Med Sci 2011;11: 30-8. https://doi.org/10.3923/jms.2011.30.38
  8. Mitsuhashi T, Nagase M, Arai H. Efficacy of goreisan for asymptomatic bilateral and unilateral chronic subdural hematoma. Traditional & Kampo Medicine 2015.
  9. Okamura A, Kawamoto Y, Sakoda E, Murakami T, Hara T. Evaluation of recurrence factors and Gorei-san administration for chronic subdural hematoma after percutaneous subdural tapping. Hiroshima J Med Sci 2013;62(4):77-82.
  10. Utsuki S, Oka H, Kijima C, Inukai M, Abe K, Sato K, et al. Effect of postoperative administration of Saireito for bilateral chronic subdural hematomas. Int J Clin Med 2011;2(3):285-8. https://doi.org/10.4236/ijcm.2011.23047
  11. Utsuki S, Oka H, Inukai M, Abe K, Fujii K. Role of saireito in postoperative chronic subdural hematoma recurrence prevention. J Trad Med 2012;29(3):137-42.
  12. Cho KH, Kwon SW, Jung WS, Moon SK. Herbal Medicine, Oreongsan for Recurrent Chronic Subdural Hematoma: A Case Report. EXPLORE: The Journal of Science and Healing 2016;13(2): 139-41. https://doi.org/10.1016/j.explore.2016.12.008
  13. Yasunaga H. Effect of Japanese herbal Kampo medicine goreisan on reoperation rates after burr-hole surgery for chronic subdural hematoma: analysis of a national inpatient database. Evidence-Based Complementary and Alternative Medicine 2015.
  14. Hayashi A, Sato H. A New Oriental Medical Approach To Eliminate Brain Edema Complicated With Malignant Brain Tumors: Efficacy Of Goreisan(an Aquaporin Inhibiter). Neuro-oncology 2010;12(3):27.

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