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Studies on the Function of Lactic Acid Bacteria and Related Yeasts in Probiotics: A Review

프로바이오틱스 중 유산균 및 관련 효모의 기능에 관한 연구 고찰

  • 윤진아 (케이씨대학교 식품영양학과) ;
  • 신경옥 (삼육대학교 식품영양학과)
  • Received : 2017.04.17
  • Accepted : 2017.05.31
  • Published : 2017.06.30

Abstract

Probiotics may be defined as microbial agents that can benefit humans and have been used primarily by mankind in fermented foods. A representative of probiotics is lactic acid bacteria (LAB), which has received attention recently due to its perceived health benefits. We reviewed research papers about Bifidobacerium and Lactobacillus, which are two of the most known of the LAB. Bifidobacerium alleviates diarrhea from various causes by improving intestinal microflora, and it has been reported that it reduces Helicobacter pylori bacteria known as the cause of gastric ulcer and stomach cancer. Bifidobacerium has also reported to be effective on immunization and allergy, reduce blood cholesterol, cancer, lactose intolerance. Lactobacillus alleviates diarrhea but has not fully demonstrated its effectiveness relative to other health issues. Several lactic acid bacteria and yeast are expected to act as probiotics, so, in the future, more research on the health benefits of lactic acid bacteria is needed.

Keywords

References

  1. Abd El-Gawad I, El-Sayed EM, Hafez SA, El-Zeini HM, Saleh FA. 2005. The hypocholesterolemic effect of milk yoghurt and soy-yoghurt containing Bifidobacteria in rats fed on cholesterol-enriched diet. Int Dairy J 15:37-44 https://doi.org/10.1016/j.idairyj.2004.06.001
  2. Ahmed S, Macfarlane GT, Fite A, McBain AJ, Gilbert P, Macfarlane S. 2007. Mucosa-associated bacterial diversity in relation to human terminal ileum and colonic biopsy samples. Appl Environ Microbiol 73:7435-7442 https://doi.org/10.1128/AEM.01143-07
  3. Alander M, Matto J, Kneifel W, Johansson M, Koggler B, Crittenden R, Mattila-Sandholm T, Saarela M. 2001. Effect of galacto-oligosaccharide supplementation on human fecal microflora and on survifal and persistence of Bifidobacterium lactis Bb-12 in the gastro-intestinal tract. Int Dairy J 11:817-825 https://doi.org/10.1016/S0958-6946(01)00100-5
  4. Alm L, Ryd-Kjellen E, Setterberg g, Blimquist L. 1993. Effect of new fermented milk product, Cultura, on constipation in geriatric patients. 1st Lactic Acid Bacteria Norfolk Computer Conf. Proc Horizon Scientific Press
  5. An SJ, Kim JY, Choi IS, Cho KK. 2013. Insight into the roles of prebiotics and probiotics in the large intestine. J Life Sci 23:1295-1303 https://doi.org/10.5352/JLS.2013.23.10.1295
  6. Anandharaj M, Sivasankari B, Santhanakaruppu R, Manimaran M, Rani RP, Sivakumar S. 2015. Determining the probiotic potential of cholesterol-reducing Lactobacillus and Weissella strains isolated from gherkins (fermented cucumber) and south Indian fermented koozh. Res Microb 166:428-439 https://doi.org/10.1016/j.resmic.2015.03.002
  7. Asahara T, Kensuke S, Nomoto K, Hamabata T, Ozawa A, Takeda Y. 2004. Probiotic Bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157:H7. Infect Immun 72:2240-2247 https://doi.org/10.1128/IAI.72.4.2240-2247.2004
  8. Baka M, Noriega E, Mertens L, Van Derlinden E, Van Impe JFM. 2014. Protective role of indigenous Leuconostoc carnosum against Listeria monocytogenes on vacuum packed Frankfurter sausages at suboptimal temperatures. Food Res Intl 66:197-206 https://doi.org/10.1016/j.foodres.2014.08.011
  9. Benno Y, Sawada K, Mitsuoka T. 1984. The intestinal microflora of infants: Composition of fecal flora in breast-fed and bottle-fed infants. Microbiol Immunol 28:975-986 https://doi.org/10.1111/j.1348-0421.1984.tb00754.x
  10. Bernardeau M, Vernoux JP, Henri-Dubernet S, Gueguen M. 2008. Safety assessment of diary microorganisms: The Lactobicillus genus. Int J Food Microbiol 126:278-285 https://doi.org/10.1016/j.ijfoodmicro.2007.08.015
  11. Bertolami MC. Faludi AA Batlouni M. 1999. Evaluation of the effects of a new fermented milk product(Gaio) on primary hypercholesterolemia. Euro J Clin Nutr 53:97-101 https://doi.org/10.1038/sj.ejcn.1600683
  12. Biavatti B. Vescovo M, Torriani S, Bottazzzi V. 2000. Bifidobacteria: history, ecology, physiology and applications. The Annals of Microbiol 50:117-131
  13. Borriello SP, Hammes WP, Holzapfel W, Marteau PM, Schrezenmeier J. Vaara M, Valtonen V. 2003. Safety of probiotics that contain Lactobacilli or Bifidobacteria. Clin Infectious Disease 36:775-80 https://doi.org/10.1086/368080
  14. Bortoluzzi C, Schmidt JM, Bordignon HLF, Fulber LM, Layter JR, Fernandes JIM. 2016. Efficacy of yeast derived glucomannan or algae-based antioxidant or both as feed additives to ameliorate mycotoxicosis in heat stressed and unstressed broiler chickens. Livestock Sci 193:20-25 https://doi.org/10.1016/j.livsci.2016.09.005
  15. Boyle RJ, Robins-Browne RM, Tang MLK. 2006. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr 83:1256-1264 https://doi.org/10.1093/ajcn/83.6.1256
  16. Burke W, Fesinmeyer M, Reed k, Hampson L, Calstern C. 2003. Family history as a predictor of asthma risk. Am J Prev Med 24:160-169 https://doi.org/10.1016/S0749-3797(02)00589-5
  17. Cannon JP, Lee TA, Bolanos JT. Danziger LH. 2005. Pathogenic relevance of Lactobacillus: a retrospectivve review of over 200 cases. Euro J Clin Microbiol Infectious Diseases 24:31-40 https://doi.org/10.1007/s10096-004-1253-y
  18. Chen C, Rui X, Lu Z, Li W, Dong M. 2014. Enhanced shelf-life of tofu by using bacteriocinogenic Weissella hellenica D1501 as bioprotective cultures. Food Ctrl 46:203-209
  19. Choi WJ, Konkit M, Kim Y, Kim MK, Kim W. 2016. Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice. J Dairy Sci 99:6889-6901 https://doi.org/10.3168/jds.2016-11301
  20. Choraqui JP, Van Egroo LD, Fichot MC. 2004. Acidified milk formula supplemented with Bifidoacterium lactis: Impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr 38:288-292 https://doi.org/10.1097/00005176-200403000-00011
  21. Colombel JF, Corot A, Neut C, Romond c. 1987. Yoghurt with Bifidobacterium longum reduces erythromycin-induced gastrointestinal effects. Lancet 2:43
  22. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland I. 2005. Effects of fermentation products of pro- and prebiotics on transepithelial electrical resistance in an in vitro model of the colon. Nutr Cancer 51:102-109 https://doi.org/10.1207/s15327914nc5101_14
  23. Crittenden RG, Martinex NR, Playne MJ. 2003. Synthesis and utilisation of folate by yoghurt starter cultures and probiotic bacteria. Int J Food Microbiol 80:212-222
  24. Daniel C, Titecat M, Poiret S, Cayet D, Boutillier D, Simonet M, Sirard JC, Lemaitre N, Sebbane F. 2016. Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis. Vaccine 34: 5762-5767 https://doi.org/10.1016/j.vaccine.2016.09.060
  25. Deguchi Y, Morishita T, Mutai M. 1985. Comparative studies on synthesis of water-soluble vitamins among human species of Bifidobacteria. Agric Biol Chem 49:13-16
  26. De Groote MA, Frank DN, Dowell E, Glode MP, Pace NR. 2005. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatric Infectious Diseases 24:278-280 https://doi.org/10.1097/01.inf.0000154588.79356.e6
  27. DSMZ, Bacterial nomenclature up-to-date: http://www.dmsz.de [cited 6 November 2016]
  28. D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. 2002. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 324(7350):1361 https://doi.org/10.1136/bmj.324.7350.1361
  29. Edwards CA, Parrett AM. 2002. Intestinal flora during the first months of life: new perspectives. Brit J Nutr 88(Suppl. 1):S11-S88 https://doi.org/10.1079/BJN2002625
  30. Food and Agriculture Organisation. 2006. Anon. Probiotics in food-health and nutritional properties and guidelines for evaluation. FAO Food and Nutrition Paper 85
  31. Food and Agriculture Organisation, World Health Organisation. 2002. Guidelines for the evaluation of probiotics in food. FAO/WHO Guidelines
  32. Fukushima Y, Li ST, Hara H, Terda A, Mitsuoka T. 1997. Effect of follow-up formula containing Bifidobacteria(NAN BF) on fecal flora and fecal metabolites in healthy children. Bioscience and Micro Flora 16:65-72 https://doi.org/10.12938/bifidus1996.16.65
  33. Hammes WP, Hertel C. 2006. The genera Lactobicillus and Carnobacterium. Prokaryotes 4:320-403
  34. Hatoum R, labrie S, Fliss I. 2012. Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications. Frontiers in Microbiol 3:421
  35. He T, Priebe MG, Zhong Y, Huang C, Harmsen HJM, Raangs GC, Antoine JM, Welling GW, Vonk RJ. 2008. Effects of yogurt and Bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol 104:595-604
  36. Hopkins MJ, Sharp R, Macfarlane GT. 2001. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance and community cellular fatty acid profiles. Gut 48:198-205 https://doi.org/10.1136/gut.48.2.198
  37. Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. 2000. Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1604-1610
  38. Jiang T, Mustapha A, Savaiano DA. 1996. Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J Dairy Sci 79:750-757 https://doi.org/10.3168/jds.S0022-0302(96)76422-6
  39. Kang H, Moon JS, Lee MG, Han NS. 2016. Immunomodulatory effects of Leuconostoc citreum EFEL2061 isolated from kimchi, a traditional Korean food, on the Th2 type-dominant immune response in vitro and in vivo. J Functional Foods 20:79-87 https://doi.org/10.1016/j.jff.2015.10.028
  40. Kim YH. 2016. Probiotics, prebiotics, synbiotics and human health. BT News 23:17-22
  41. Klaver FAM, van der Meer R. 1993. The assumed assimilation of cholesterol by Lactobacilli and Bifidobacterium bifidum in due to their bile salt-decnjugating activity. App Environ Microbiol 59:1120-1124
  42. Kondo S, Takahashi T, Yoshida K, Mizoguchi H. 2012. Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis. J Biosci Bioeng 114:424-428 https://doi.org/10.1016/j.jbiosc.2012.05.016
  43. Kosikowski FY, Mistry VV. 1999. Cheese & Fermented Milk Foods, Edwards Brooktondale, NY, 3rd ed
  44. Kuda T, Noguchi Y, Ono M, Takahashi H, Kimura B, Kamita R, Eto T, Kato M, Kawahara M. 2014a. In vitro evaluation of the fermentative, antioxidant, and anti-inflammation properties of Lactococcus lactis subsp. lactis BF3 and Leuconostoc mesenteroides subsp. mesenteroides BF7 isolated from Oncorhynchus keta intestines in Rausu, Japan. J Functional Foods 11:269-277 https://doi.org/10.1016/j.jff.2014.09.017
  45. Kuda T, Tomomi K, Kawahara M, Takahashi H, Kimura B. 2014b. Inhibitory effects of Leuconostoc mesenteroides 1RM3 isolated from narezushi on lipopolysaccharide-induced inflammation in RAW264.7 mouse macrophage cells and dextran sodium sulphate-induced inflammatory bowel disease in mice. J Functional Foods 6:631-636 https://doi.org/10.1016/j.jff.2013.11.017
  46. Kunz AN, Noel JM, Fairchok MP. 2004. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatric Gastroenterology Nutr 38:457-458 https://doi.org/10.1097/00005176-200404000-00017
  47. Land MH, Rouster-Stevens K, Woods CR, Cannon ML. 2005. Lactobacillus species associated with probiotic therapy. Pediatrics 115:178-181 https://doi.org/10.1542/peds.2004-2137
  48. Larsen LA, Raben A, Haulrik N, Hansen AS, Manders M, Astrop A. 2000. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Euro J Clin Nutr 54:288-297 https://doi.org/10.1038/sj.ejcn.1600937
  49. Leahy SC, Higgins DG, Fitzgerald GF, van Sinderen D. 2005. Getting better with Bifidobacteria. J Appl Microbiol 98:1303-13153 https://doi.org/10.1111/j.1365-2672.2005.02600.x
  50. Lee KW, Park JY, Jeong HR, Heo HJ, Han NS, Kim JH. 2012. Probiotic properties of Weissella strains isolated from human faeces. Anaerobe 18:96-102 https://doi.org/10.1016/j.anaerobe.2011.12.015
  51. Lesbros-Pantoflickova D, Corthesy-Theulaz I, Blum AL. 2007. Helicobacter pylori and probiotics. J Nutr 137(3 Suppl 2):812S-818S https://doi.org/10.1093/jn/137.3.812S
  52. Leu RL, Brown IL, Hu Y, Bird AR, Jackson M, Esterman A, Young GP. 2005. A symbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon. J Nutr 135:996-1001 https://doi.org/10.1093/jn/135.5.996
  53. Link-Amster H, Rochat F, Sauda KY, Mignot O, Aeschlimann JM. 1994. Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol 10:55-64 https://doi.org/10.1111/j.1574-695X.1994.tb00011.x
  54. Lilly DM, Stillwell RH. 1965. Probiotics: Growth-promoting factors produced by microorganisms. Science 147:747-748 https://doi.org/10.1126/science.147.3659.747
  55. Luckey TD. 1972. Introduction to intestinal microecology. Am J Clin Nutr 25:1292-1294 https://doi.org/10.1093/ajcn/25.12.1292
  56. Lv, JP, Wang LM. 2009. Bioactive Components in Kefir and Koumiss, in Bioactive Components in Milk and Dairy Products. Wieley-Blackwell, Iowa, USA, pp.251-262
  57. Macfarlance GT, Steed H, Macfarlane S. 2008. Bacterial metabolism and health-related effects of galacto- oligosaccharides and other probiotics. J Appl Microbiol 104:305-344
  58. Mackay AD, Taylor MB, Kibbler CC, Hammilton-Miller JMT. 1999. Lactobacillus endocarditis caused by a probiotic organism. J Pediatric Gastroenterology Nutr 38:457-458
  59. Mann EJ. 1983. Kefir and koumiss. Dairy Industries International 48:9-10
  60. Martin Furr. 2014. Orally administered Pediococcus acidilactici and Saccharomyces boulardii-based probiotics alter select equine immune function parameters. J Equine Vet Sci 34:1156-1163 https://doi.org/10.1016/j.jevs.2014.06.020
  61. Matsumoto M, Benno Y. 2004. Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healty adult subjects. Mutation Res 568:147-153 https://doi.org/10.1016/j.mrfmmm.2004.07.016
  62. Matsumoto M, Imai T, Hironaka T, Kume H, Watanabe M, Benno Y. 2001. Effect of yogurt with Bifidobacterium lactis LKM512 in improving fecal microflora and defecation of health volunteers. J Intestinal Microbiol 14:97-102
  63. Meile L. Ludwig U, Gut C, Kaufmann P, Dasen G, Wenger S, Teuber M. 1997. Bifidobacterium lactis sp. nov. a moderately oxygen tolerant species isolated from fermented milk. Syst Appl Microbiol 20:20-57 https://doi.org/10.1016/S0723-2020(97)80044-6
  64. Monnet V, Condon S, Cogan TM, Gripon JC. 1996. Metabolism of starter cultures. in Dairy Starter Cultures. pp. 47-56. VCH Publishers Inc
  65. Murofushi M, Shiomi M, Aibara K. 1983. Effect of orally administered polysaccharide from kefir grain on delayed-type hypersensitivity and tumor growth in mice. Jpn J Med Sci Biol 36:49-53 https://doi.org/10.7883/yoken1952.36.49
  66. Nonklang S, Abdel-Banat Babiker MA, Cha-aim K, Moonjai N, Hoshida H, Limtong S, Yamada M, Akada R. 2008. High-temperature ethanol fermentation and transformation with linear DNA in the thermotolerant yeast Kluyveromyces marxianus DMKU3-1042. Appl Environ Microbiol 74:7514-7521 https://doi.org/10.1128/AEM.01854-08
  67. O'Brien J. Crittenden R, Ouwehand AC. Salminen S. 1999. Safety evaluation of probiotics. Trends in Food Sci Tech 10:418-424 https://doi.org/10.1016/S0924-2244(00)00037-6
  68. O'May GA, Macfarlane GT. 2005. Health Claims associated with Probiotics, in Probiotic Dairy Products. Oxford, UK, Blackwell Publishing, pp.138-166
  69. Parente E, Ricciardi A. 1999. Production, recovery and purification of bacteriocins from lactic acid bacteria. Appl Microbiol Biotechnol 52:628-638 https://doi.org/10.1007/s002530051570
  70. Pereira DIA, Gibson GR. 2002. Cholesterol assimilation by lactic acid bacteria and Bifidobacteria isolated from the human gut. Appl Environ Microbiol 68:4689-4693 https://doi.org/10.1128/AEM.68.9.4689-4693.2002
  71. Plummer S, Weaver MA, Harris JC, Dee P, Hunter J. 2004. Clostridium difficile pilot study: effects of probiotic supplementation on the indigene of C. difficile diarrhea. Int J Microbiol 7:59-62
  72. Rautava S, Arvilommi H, Isolauri E. 2006. Specific probiotics in enhancing maturation of IgA responses in formula fed infants. Pediatric Res 60:222-225
  73. Rautio M, Jousimies-Somer H, Kauma H, Pietarinen I, Saxelin M, Tynkkynen S, Koskela M. 1999. Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L. rhamnous strain GG. Clin Microbiol Infection 6:290-292
  74. Reid G, Jass J, Sebulsky MT, McCormick JK. 2003. Potential uses of probiotics in clinical practice. Clin Microbiol Rev 16:658-672 https://doi.org/10.1128/CMR.16.4.658-672.2003
  75. Robinson R. (Ed.), 2014. Encyclopedia of Food Microbiology, 2. Auflage ed. Acad. Press San Diego
  76. Rowland I, Rumney C, Outts J, Lievense L. 1998. Effects of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen induced aberrant crypt foci in rats. Carcinogenesis 19:281-285 https://doi.org/10.1093/carcin/19.2.281
  77. Saarela M, Matto J, Mattila-Sandholm T. 2002. Safety aspects of Lactobacillus and Bifidobacterium species originating from human oro-gastrointestinal tract or from probiotic products. Microb Ecol Health Dis 14:233-240
  78. Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. 1994. Feeding of Bifidobacterium bifidum and Sterptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rora virus. Lancet 344:4016-1049 https://doi.org/10.1016/S0140-6736(94)91708-6
  79. Sagen O. 1989. Treatment of functional disturbance in the intestine by administration of lactic acid bacteria. Chr. Hansen A/S, Denmark, International Report.
  80. Salminen MK, Tykkynen S, Rautelin H, Saxelin M, Vaara M, Ruutu P, Sarna S, Valtonen V, Jarvinen A. 2002. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland. Clin Infectious Diseases 35:1155-1160 https://doi.org/10.1086/342912
  81. Satokari RM, Vaughan EE, Smidt H, Saarela M, Matto J, de Vos WM. 2003. Molecular approches for the detection and identification of Bifidobacteria and Lactobacilli in the human gastrointestinal tract. Systematic and Appl Microbiol 26:572-584 https://doi.org/10.1078/072320203770865882
  82. Sheu BS, Cheng HC, Kao AW, Wang ST, Yang YJ, Yang HB, Wu JJ. 2006. Pretreatment with Lactobacillus and Bifidobacterium containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 83:864-869 https://doi.org/10.1093/ajcn/83.4.864
  83. Shibata T, Kanayama M, Haida M, Fujimoto S, Oroguchi T, Sata K, Mita N, Kutsuzawa T, Ikeuchi M, Kondo M, Naito K, Tsuda M, Nishizaki Y, Ishi N. 2016. Lactococcus lactis JCM5805 activates anti-viral immunity and reduces symptoms of common cold and influenza in healthy adults in a randomized controlled trial. J Functional Foods 24:492-500 https://doi.org/10.1016/j.jff.2016.03.035
  84. Silva AM, Barbosa FHF, Duarte R, Vieira LQ, Arantes RME, Niocli JR. 2003. Effect of Bifidobacterium longum ingestion on experimental salmonellosis in mice. J Appl Microbiol 97:29-37
  85. Shin MY, Kwun IS. 2016. Vitamin D: hormone-like nutrient. J Nutr and Health 49:1-7 https://doi.org/10.4163/jnh.2016.49.1.1
  86. Smith IM, Baker A, Arneborg N, Jespersen L. 2015. Non-Saccharomyces yeasts protect against epithelial cell barrier disruption induced by Salmonella enterica subsp. enterica serovar. Typhimurium. Lett Appl Microbiol 61:491-497 https://doi.org/10.1111/lam.12481
  87. Spohner SC, Schaum V, Quitmann H, Czermak P. 2016. Kluyveromyces lactis: An emerging tool in biotechnology. J Biotechnol 222:104-116 https://doi.org/10.1016/j.jbiotec.2016.02.023
  88. Stratakos AC, Linton M, Tessema GT, Skjerdal T, Patterson MF, Koidis A. 2016. Effect of high pressure processing in combination with Weissella viridescens as a protective culture against Listeria monocytogenes in ready-to-eat salads of different pH. Food Ctrl 61:6-12
  89. Tahri K, Grill JP, Schneider F. 1996. Bifidobacteria strains behaviour toward cholesterol: coprecipitation with bile salts and assimilation. Current Microbiol 33:187-193 https://doi.org/10.1007/s002849900098
  90. Tahri K, Grill JP, Schneider F. 1997. Involvement of trihydroxy-conjugated bilsalts in cholesterol assimilation by Bifidobacteria. Current Microbiol 34:79-84 https://doi.org/10.1007/s002849900148
  91. Tanaka R, Shimosaka K. 1982. Investigation of the stool frequency in elderly, who are bedridden and its improvement by ingesting bifidus yogurt. Japanese J Geriatrics 19:577-82 https://doi.org/10.3143/geriatrics.19.577
  92. Tannock GW. 1997. Probiotic properties of lactic-acid bacteria: plenty of scope for fundamental R&D. Trends Biotechnol 15:270-274 https://doi.org/10.1016/S0167-7799(97)01056-1
  93. Tomoda T, Nakano Y, Kageyama T. 1983. Variation of intestinal Candida of patients with leukaemia and the effects of Lactobacillus administration. Japanese J Med Mycology 24:356-358 https://doi.org/10.3314/jjmm1960.24.356
  94. Toure R, Kheadr E, Lacroix C, Moroni O, Fliss I. 2003. Production of antibacterial sunstances by bifidobacterial isolates from infant stool active against Listeria monocytogenes. J Appl Microbiol 95:1058-1069 https://doi.org/10.1046/j.1365-2672.2003.02085.x
  95. Tzortzis G. Goulas AK, Gee JM, Gibson GR. 2005. A novel galactooligosaccharide mixture increases the bifidobacterial population numbers in a continuous in vitro fermentation system and in the proximal colonic contents of pigs in vitro. J Nutr 135:1726-1731 https://doi.org/10.1093/jn/135.7.1726
  96. Vernazza CL, Gibson GR, Rastall RA. 2006. Carbohydrate preference, acid tolerance and bile tolerance on five strains of Bifidobacterium. J Appl Microbiol 100:846-853 https://doi.org/10.1111/j.1365-2672.2006.02832.x
  97. Waligora-Dupriet AJ, Campeotto F, Nicolis I, Bonet A, Soulaines P, Dupont C, Butel MJ. 2007. Effect of oligofructose supplementation on gut microflora and wellbeing in young children attending a day care centre. Int J Food Microbiol 113:108-113 https://doi.org/10.1016/j.ijfoodmicro.2006.07.009
  98. Wang KY, Li SN, Liu CS, Perng DS, Wi DC, Jan CM, lai CH, Wang TN, Wang Wm. 2004. Effects of ingesting Lactobacillus and Bifidobacterium containing yogurt in subjects with colonised Helicobacter pylori. Am J Clin Nutr 80:737-741
  99. Wanger RD, Pierson C, Warner T, Dohnalek M, Farmer J, Roberts L, Hilty M, Balish E. 1997. Biotherapeutic effects of probiotic bacteria on cadidiasis in immunodeficient mice. Infection and Immunity 65:4165-4172
  100. Warren JR, Marshall B. 1983. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273-1275
  101. Wasilewski A, Zielinska M, Storr M, Fichna J. 2015. Beneficial effects of probiotics, prebiotics, synbiotics and psychobiotics in inflammatory Bowel Disease. Inflamm Bowel Dis 21:1674-1682 https://doi.org/10.1097/MIB.0000000000000364
  102. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV. 2008. Innate immunity and intestinal microbita in the development of Type 1 diabetes. Nature 455:1109-1113 https://doi.org/10.1038/nature07336