한국임상약학회지 (Korean Journal of Clinical Pharmacy)

  • 제27권2호
  • /
  • Pages.113-118
  • /
  • 2017
  • /
  • 1226-6051(pISSN)
  • /
  • 2508-786X(eISSN)
한국임상약학회 (Korean College Of Clinical Pharmacy)
권호 표지
DOI QR코드

DOI QR Code

대표적인 국제 소아 천식 약물요법 가이드라인에 대한 비교 연구

A Comparison of International Guidelines for Pediatric Asthma Pharmacotherapy

  • 투고 : 2017.05.31
  • 심사 : 2017.06.28
  • 발행 : 2017.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: International institutes such as Global institute for Asthma(GINA), KAAACI(Republic of Korea), NHLBI(USA), BTS(UK) and JSA(Japan) have published guidelines for asthma treatment. The aim of this study was to compare the representatives' international guidelines of pharmacotherapy for pediatric asthma. Methods: The recommendations related to pharmacotherapy for pediatric asthma were extracted from the latest representatives' international guidelines, and comprehensive comparisons were conducted. Results: Major comparison outcomes between international guidelines were evaluated as follows: classification system on severity and pediatric age group, recommendation for inhaled corticosteroid dose, recommendation for pediatric age group of theophylline in mild asthma, and recommendation for pediatric age group of tiotropium in severe asthma. Clinical trials emphasized the adverse effects of theophylline, whereas tiotropium demonstrated beneficial actions for pediatric asthma. Therefore, theophylline was recommended for older patients with persistent asthma, and tiotropium was considered to be suitable for younger patients with severe asthma according to GINA guidelines. Conclusion: These findings address the requirement to harmonize international guidelines of pharmacotherapy in pediatric asthma. In addition, the findings suggest that KAAACI needs to update its pharmacotherapy guidelines of theophylline, tiotropium and other medicines recently approved.

키워드

참고문헌

  1. Pearce N, Ait-Khaled N, Beasley R, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007;62(9):758-66. https://doi.org/10.1136/thx.2006.070169
  2. Lieu TA, Quesenberry CP, Capra AM, et al. Outpatient management practices associated with reduced risk of pediatric asthma hospitalization and emergency department visits. Pediatrics 1997;100(3):334-41. https://doi.org/10.1542/peds.100.3.334
  3. Bursch B, Schwankovsky L, Gilbert J, et al. Construction and validation of four childhood asthma self-management scales: parent barriers, child and parent self-efficacy, and parent belief in treatment efficacy. J Asthma 1999;36(1):115-28. https://doi.org/10.3109/02770909909065155
  4. Health Insurance Review & Assessment Service, Healthcare Bigdata Hub. Available from http://opendata.hira.or.kr/op/opc/olapHifrqSick-Info.do, Accessed January 12, 2017.
  5. Martin RJ, Kraft M, Chu HW, et al. A link between chronic asthma and chronic infection. J Allergy Clin Immunol 2001;107(4):595-601. https://doi.org/10.1067/mai.2001.113563
  6. Price JF. Issues in adolescent asthma: what are the needs?. Thorax 1996;51(Suppl 1):S13-7. https://doi.org/10.1136/thx.51.Suppl_1.S13
  7. Cottrell L, Neal WA, Ice C, et al. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med 2011;183(4):441-8. https://doi.org/10.1164/rccm.201004-0603OC
  8. Ginsberg G, Hattis D, Sonawane B, et al. Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. Toxicol Sci 2002;66(2):185-200. https://doi.org/10.1093/toxsci/66.2.185
  9. Cloutier MM, Wakefield DB, Sangeloty-Higgins P, et al. Asthma guideline use by pediatricians in private practices and asthma morbidity. Pediatrics 2006;118(5):1880-7. https://doi.org/10.1542/peds.2006-1019
  10. Jang JK, Kim HS, Sohn HS, et al. Drug Prescribing Patterns for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease in Korea. Kor J Clin Pharm 2014;24(1):26-32.
  11. Lee EK, Bae EY, Park EJ, et al. Pattern of asthma management by primary physicians in Seoul. Tuberc Respir Dis 2003;55(2):165-74. https://doi.org/10.4046/trd.2003.55.2.165
  12. Vogelberg C, Moroni-Zentgraf P, Leonaviciute-Klimantaviciene M, et al. A randomised dose-ranging study of tiotropium Respimat(R) in children with symptomatic asthma despite inhaled corticosteroids. Respir Res 2015;16(20.):1-10. https://doi.org/10.1186/s12931-014-0139-5
  13. Vogelberg C, Engel M, Moroni-Zentgraf P, et al. Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: a randomised dose-ranging study. Respir Med 2014;108(9):1268-76. https://doi.org/10.1016/j.rmed.2014.06.011
  14. Soren EP, Eric DB, Louis PB, et al. Global Strategy for Asthma Management and Prevention (2017 update). Available from http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-managementand-prevention/. Accessed April 8, 2017.
  15. Korean Guideline for Asthma. Available from http://www.allergy.or.kr/file/150527_01.pdf. Accessed May 29, 2017
  16. National Heart, Lung, and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma: full report. US Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute 2007. Available from https://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf. Accessed May 29, 2017
  17. British thoracic society(BTS). SIGN 153 . British guideline on the management of asthma. 2016. Available from https://www.brit-thoracic. org.uk/standards-of-care/guidelines/btssign-british-guideline-onthe-management-of-asthma/. Accessed January 16, 2017.
  18. Hamasaki Y, Kohno Y, Ebisawa M, et al. Japanese guideline for childhood asthma 2014. Allergol Int 2014;63(3):335-56. https://doi.org/10.2332/allergolint.14-RAI-0767