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A Case Report of Idiopathic Precocious Puberty in Two Children

특발성 성조숙증으로 진단받은 환아 2례에 대한 증례보고

  • Lee, Hye Lim (Department of Pediatrics, College of Korean Medicine, Gachon University) ;
  • Yoo, Hwa Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, Seung Chan (Highki Korean Medicine Clinic)
  • 이혜림 (가천대학교 한의과대학 소아과학교실) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터) ;
  • 박승찬 (하이키 한의원)
  • Received : 2017.01.20
  • Accepted : 2017.02.11
  • Published : 2017.02.28

Abstract

Objectives The purpose of this study is to report the case of precocious puberty in two children treated by taking herbal medicine. Methods Two patients diagnosed with precocious puberty were prescribed Jogyeongseongjang-tang and were observed the effect of treatment on height, body weight, body composition, sex hormone test. Results During the treatment period, rapid progression of puberty was inhibited, and slow changes in sex hormones and steady growth were achieved. Conclusions This study showed the long-term effects of herbal medicine in treating precocious puberty, but further studies should be conducted for scientific validation.

Keywords

References

  1. Berberoglu M. Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol. 2009;1:164-74. https://doi.org/10.4274/jcrpe.v1i4.3
  2. Korean Society of Pediatric Endocrinology. Pediatric endocrinology. 3rd ed. Seoul: Koonja Press. 2014:417-35.
  3. Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and stature growth. Hum Reprod Update. 2004;10:135-47. https://doi.org/10.1093/humupd/dmh012
  4. Choi KH, Park SC. An increase of patients diagnosed as precocious puberty among Korean children from 2010 to 2015. J Pediatr Korean Med. 2016;30(4):60-5. https://doi.org/10.7778/jpkm.2016.30.4.060
  5. Carel JC, Leger J. Precocious puberty. N Engl J Med. 2008;358:2366-77. https://doi.org/10.1056/NEJMcp0800459
  6. Partsch CJ, Sippell WG. Pathogenesis and epidemiology of precocious puberty, effects of exogenous oestrogens. Hum Reprod Update. 2001;7:292-302. https://doi.org/10.1093/humupd/7.3.292
  7. Roger M, Lahlou N, Chaussain JL. Gonadotropin-releasing hormone testing in pediatrics. In: Ranke MB, editor. Diagnostics of endocrine function in children and adolescents. Heidelberg, Germany: Johann Ambrosius Barth Verlag. 1996:346-69.
  8. Neely EK, Hintz RL, Wilson DM, Lee PA, Gau tier T, Argente J, Stene M. Normal ranges for immunochemiluminometric gonadotropin assays. J Pediatr. 1995;127:40-6. https://doi.org/10.1016/S0022-3476(95)70254-7
  9. Lim JS, Lee HS, Kim EY, Yi KH, Hwang JS. Early menarche increases the risk of type 2 diabetes in young and middle-aged Korean women. Diabet Med. 2015;32:521-5. https://doi.org/10.1111/dme.12653
  10. Baek TH, Lim NK, Kim MJ, Lee JW, Ryu SH, Chang YS, Choi Y, Park HY. Age at menarche and its association with dysglycemia in Korean middle-aged women. Menopause. 2015;22:542-8. https://doi.org/10.1097/GME.0000000000000353
  11. Gong TT, Wang YL, Ma XX. Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies. Sci Rep. 2015;5:140-51.
  12. Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR. Consensus statement on the use of gonadotropinreleasing hormone analogs in children. Pediatr. 2009;123:752-62. https://doi.org/10.1542/peds.2008-1783
  13. Klein KO, Barnes KM, Jones JV, Feuillan PP, Cutler GB. Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab. 2001;86:4711-6. https://doi.org/10.1210/jcem.86.10.7915
  14. Paul DL, Conte FA, Grumbach MM, Kaplan SL. Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years. J Clin Endocrinol Metab. 1995;80:546-51.
  15. Lazar L, Padoa A, Phillip M. Growth pattern and final height after cessation of gonadotropin-suppressive therapy in girls with central sexual precocity. J Clin Endocrinol Metab. 2007;92:3483-9. https://doi.org/10.1210/jc.2007-0321
  16. Baek KH, Jin DG. Etiology and age incidence of precocious puberty. J Korean Soc Pediatr Endocrinol. 2002;7(2):199-205.
  17. Lee YJ, Lee KH. Overview and treatment of precocious puberty. J Korean Med Assoc. 2015;58(12):1138-44. https://doi.org/10.5124/jkma.2015.58.12.1138
  18. Kim EY. Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty. Korean J Pediatr. 2015;58(1):1-7. https://doi.org/10.3345/kjp.2015.58.1.1
  19. Jung KM, Sin SH, Lee SA, Pakr MJ, Kim SH. Psychological characteristics of girls with precocious puberty. J Korean Health Psychol. 2012;17(2):461-77. https://doi.org/10.17315/kjhp.2012.17.2.012
  20. Kim KH, Shin DG, Kin DH. Estimated factors and clinical characteristics of children diagnosed with idiopathic prcocious puberty. J Pediatr Korean Med. 2011;25(2):111-20. https://doi.org/10.7778/jpkm.2011.25.2.111
  21. Lim YK, Hur KW, Park SY, Suh KS, Chun SY, Lee SJ, Lee H, Kim HC. A case report of precocious puberty in a female patient: significant improvement in controlling the sex hormone levels. J Pediatr Korean Med. 2014;28(4):64-70. https://doi.org/10.7778/jpkm.2014.28.4.064
  22. Kim JE, Yang SJ, Cho SH, Park KM. A report on the effect of Jowisengchoun-tang in 2 cases of precocious puberty. J Korean Obstet Gynecol. 2013;26(2):178-87. https://doi.org/10.15204/jkobgy.2013.26.2.178
  23. Korean Society of Pediatric Endocrinology. Clinical Guidelines. Seoul: Ui hak moon hwa sa. 2011.
  24. Carel JC, Leger J. Precocious puberty. N Engl J Med. 2008;358:2366-77. https://doi.org/10.1056/NEJMcp0800459
  25. Kim KB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yu SA, Lee SY, Lee JY, Chang GT, Jung MJ, Chai JW, Cheon JH, Han YJ, Han JK. Hanbangsoacheongsonyeonuihak. Seoul: Ui Sung Dang Publishing co. 2015:99-104.

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