The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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The Trend of Clinical Research on Treatment for Precocious Puberty - Focusing on Recent Studies in the Chinese Medical Journal CAJ -

성조숙증 치료에 대한 임상 연구 동향 -최근 중의학 저널을 중심으로-

  • Kweon, Ji Hyeon (Department of Pediatrics, College of Oriental Medicine, Dongeui University) ;
  • Lee, Seung Yeon (Department of Pediatrics, College of Oriental Medicine, Dongeui University) ;
  • Yu, Sun Ae (Department of Pediatrics, College of Oriental Medicine, Dongeui University)
  • 권지현 (동의대학교 한의과대학 소아과학교실) ;
  • 이승연 (동의대학교 한의과대학 소아과학교실) ;
  • 유선애 (동의대학교 한의과대학 소아과학교실)
  • Received : 2017.01.20
  • Accepted : 2017.02.09
  • Published : 2017.02.28
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Abstract

Objectives The purpose of this study is to analyze recent clinical studies on treatment for precocious puberty. Methods 28 clinical studies from January 2009 to December 2016 about precocious puberty from the China Academic Journal (CAJ), China National Knowledge Infrastructure (CNKI), were selected and reviewed: 22 case control studies and 6 case series. Results The main traditional Chinese medicine (TCM) treatment was the herbal decoctions and granules. The frequently used herbs were root of Bupleurum falcatum (柴胡), fruit of Prunella vulgaris var. aleutica (夏枯草), root stem of Anemarrhena asphodeloides (知母), dried fungus nucleus of Poria cocos (茯苓), Rehmannia glutinosa var. purpurea (生地黃), peony Paeonia suffruticosa Andrews (牧丹皮), bark of Phellodendron amurense (黃柏), roots of a plant Paeoniae lactiflora (白芍藥). On the other hand, the main western medicine (WM) for precocious puberty was Gonadotropin-releasing hormone agonist (GnRHa). Total effective rate of the TCM group was 62.96-100%, that of the WM group was 36.6-93.3% and that of the TCM-WM group was 77.8-93.75%. Conclusions Traditional Chinese medicine has been shown as an effective treatment for precocious puberty. These research results can be utilized in other clinical studies and in treatment of precocious puberty.

Keywords

References

  1. Health Insurance Review and Evaluation Center. Early discovery important ganglia, maybe even my child. http://www.hira.or.kr/dummy.do?pgmid=HIRAA020041000000&cmsurl=/cms/inform/02/1205871_27116.html&subject.
  2. Health Insurance Review and Evaluation Center. Do you have any children? Diagnosis and Prevention Childhood Precocious Puberty. http://blog.naver.com/ok_hira/220737267168.
  3. Lee SY. The influence of body mass index on luteinizing hormone levels after gonadotropin-releasing hormone stimulation in girls with precocious and advanced puberty. Ann Pediatr Endocrinol Metab. 2012;17:230-6. https://doi.org/10.6065/apem.2012.17.4.230
  4. Lee KH, Kim CJ, Kim HS, Shin CH, Yang S, Lym JS, Jung MH, Jung SJ, Hwang IT, Hwang JS. The Korean society of pediatric endocrinology's precocious puberty clinical guidelines. 2011.
  5. Lee KH. Indication of combined treatment of GnRH agonist and GH. J Korean Soc Pediatr Endocrinol. 2005;10(1):24-9.
  6. Lee MJ, Chang GT, Han YJ. The study for precocious puberty in recent journals of traditional Chinese medicine. J Korean Orient Pediatr. 2008;22(1):163-87.
  7. Kim JE, Yang SJ, Cho SH, Park KM. A report on the effect of Jowisengchung-tang in 2 cases of precocious puberty. J Korean Obstet Gynecol. 2013;26(2):178-87. https://doi.org/10.15204/jkobgy.2013.26.2.178
  8. Lim YK, Hur KW, Park SY, Suh KS, Chun SY, Lee SJ, Lee H, Kim HC. A case report of precocious puberty in a female patient: significant improvement in controlling the sex hormone levels. J Pediatr Korean Med. 2014;28(4):64-70. https://doi.org/10.7778/jpkm.2014.28.4.064
  9. Choi KH, Park SC. An increase of patients diagnosed as precocious puberty among Korean children from 2010 to 2015. J Pediatr Korean Med. 2016;30(4):60-5. https://doi.org/10.7778/jpkm.2016.30.4.060
  10. Zhao J, Chen W, Lin J, Shen J, Zhu M, Yuan Y. A hundred and forty cases of clinical study on "Zaoshu Granule" for sexually precocious girls of phlegm-heat pattern. World Chin Med. 2016;11(1):65-70.
  11. Qi H, Zhang X, Xiang R. Clinical analysis of 36 cases of idiopathic central precocious puberty treated by traditional Chinese medicine and western medicine. J Tianjin Univ Tradit Chin Med. 2016;35(2):88-91.
  12. Zeng K, Yang D, Pan M, Deng W, Li L, Zeng W, Lin Z, Xu J. Clinical effect of acupoint application with Zhibai Dihuang prescription in the treatment of female children with simple premature thelarche. Chin Med Herald. 2016;13(22):89-92.
  13. Huang J, Ye J, Kong F, Li H. Forty patients with idiopathic central precocious puberty treated by clinical observation. J Tradit Chin Med Pharm. 2015;21(24):49-51.
  14. Bi M, Zhang X, Sheng L. Clinical efficacy observation of the impact of tonifying the kidney and dredging the liver-qi method on precocious puberty girls’ secondary sex characteristics and growth. J Pediatr Tradit Chin Med. 2015;11(6):23-7.
  15. Ye J, Huang J, Kong F, Li HY. Clinical research on the treating of idiopathic true precocious puberty from the perspective of supplement between spleen and kidney. J Nanjing Univ Tradit Chin Med. 2015;31(6):514-6.
  16. Yang Y, Ru J. Research on the effectiveness of TCM combined with western medicine treatment of girls idiopathic precocious puberty. J Liaoning Tradit Chin Med. 2015;42(6):1278-80.
  17. Liu XJ. Clinical research of the impact of Zaoshuyifang on the ICPP girls long-term psychological and behavioral. Master dissertation of Guangzhou university. 2014.
  18. Jang SJ. The impact of Zhi Zao particle on leptin and ghrelin in serum in girls with liver depression and stagnation type idiopathic central precocious puberty. Master dissertation of Heilongjiang university. 2014.
  19. Xiao Y, Dong Q. Prematurity second granules in treatment of girls with dyspepsia. J Tradit Chin Med. 2013;31(11):2577-80.
  20. Gwak Y. Effect of Zhi Zao particle to kisspeptin level in serum in girls with depression and stagnation type idiopathic central precocious puberty. Master dissertation of Heilongjiang university. 2013.
  21. Jang W. The study of morphological changes of the ICPP girl uterine and ovarian of Zhi Zao Ke Li. Master dissertation of Heilongjiang university. 2013.
  22. Mo S, Li W, Deng L. Analysis of psychological behavior of idiopathic central precocious puberty girls with phlegm-fire type and efficacy of Chinese medicine. J New Chin Med. 2012;44(9):42-4.
  23. Mo S, Li W, Deng L. Observation of psycho-behavioral status of idiopathic central precocious puberty girls with Yin-deficiency type and therapeutic effect of Chinese herbal medicine. J New Chin Med. 2012;44(5):63-5.
  24. Hou GN. Clinical observation of Ziazao Keli in the therapy of the girls idiopathic central precocious puberty with liver depression sputum junction. Master dissertation of Heilongjiang university. 2012.
  25. Chen Q, Wang Li. Treatment of drug granules of the second Matutitas Praecox on girls' phlegm-heat-type idiopathic precocious puberty clinical research. J Tradit Chin Med. 2011;29(1):91-4.
  26. Chen Q, Qi LL. Treatment of drug granules of the third Matutitas Praecox on Yin deficiency and fire superfluousness with the phlegm. J Tradit Chin Med. 2011;29(7):1565-8.
  27. Mo S, Deng LS, Li YS, Li WY, Zhang Q. Clinical observation on treatment of liver-depression type idiopathic precocious puberty with. J New Chin Med. 2011;43(2):84-5.
  28. Ye J, Han XM, Wu YM, Yang LL. Observation on the curative effect of anti-early granule in treating idiopathic central precocious puberty with phlegm-heat syndrome. J Shandong Med Pharm. 2011;51(17):66-8.
  29. Zhang MQ. Influence of nursing Yin and soothing liver method on hormone, insulin-like growth factor and leptin in simple premature thelarche. Master dissertation of Guangzhou university. 2010.
  30. Chen Q, Wang Y. Clinical study on hyperactivity of fire due to Yin deficiency type sexual precocity of female children treated with Zao Shu granule3. J Tradit Chin Med Pharm. 2010;17(6):479-82.
  31. Ye J, Wu YM, Hao HY. Clinical study on 30 cases of idiopathic precocious puberty treated by Huatan Xiehuo. J Tradit Chin Med. 2009;41(4):26-8.
  32. Car YL, Li J, Ma YC, Sun YH, Yang LZ, Zhang XS, Ma BZ, Shi GY. Three-dimensional ultrasonographic observation of Zhizao granule in treating girl's idiopathic precocious puberty. J Acta Chin Med Pharm. 2015;43(4):110-1.
  33. Wang L, Xin N. The curative effect of Shugan Jieyu medicine on liver Qi type ICPP in female children. J China Foreign Med Treat. 2014;24:1-2.
  34. Chen Y, Lin K, Gao X, Wang X, Ma J. To observe early clinical research of prescription in treatment of idiopathic precocious puberty girls. J Chin Exp Tradit Med. 2013;19(17):324-7.
  35. Li WY, Deng LS, Mo S. Observation on the effect of external treatment of traditional Chinese medicine on simple breast early development. J New Chin Med. 2012;44(5):68-70.
  36. Chou Y, Zheng J. Changes of ovarian volume in girls with idiopathic precocious puberty treated with. J Jilin Univ. 2012:4.
  37. Liu HL, Liu J, Liu GQ. Clinical study on treatment of 60 cases of true precocious puberty in girls with Fu-yang mixture. Beijing J Tradit Chin Med. 2009;28(8):588-9, 611.
  38. Kang HJ, Nam JS, Cho WK, Cho KS, Park SH, Jung MH, Lim GY, Suh BK, Lee B. Pelvic ultrasonography findings in girls with precocious puberty. J Korean Soc Pediatr Endocrinol. 2010;15(2):126-32.
  39. Park MJ. Recent advance in pathogenesis and treatment of precocious precocity. J Dev Reprod. 2006;10(4):215-25.
  40. Chung KM, Shin SH, Lee SA. Psychological characteristics of girls with precocious puberty. Korean J Psychol. 2012;17(2):461-77. https://doi.org/10.17315/kjhp.2012.17.2.012
  41. Jin HY, Choi JH, Yoo HW. Evaluation of efficacy of GnRH agonist on predicted adult height (PAH) in patients with central precocious puberty using two different dosages. J Korean Soc Pediatr Endocrinol. 2010;15(2):120-5.
  42. Kim ES, Jung SN, Kim MS, Lee DY, Kim CJ, Kim JD, Kim EY. Growth changes after one year of gonadotropin-releasing hormone agonist treatment in idiopathic true precocious puberty girls: multicenter study in Honam area. J Korean Soc Pediatr Endocrinol. 2010;15(1):33-43.
  43. Weiss JM, Diedrich K, Ludwig M. Gonadotropin-releasing hormone antagonists: pharmacology and clinical use in women. Treat Endocrinol. 2002;1:281-91. https://doi.org/10.2165/00024677-200201050-00002
  44. Choi JH. Proper dosage and duration of GnRH agonist treatment in central precocious puberty. J Korean Soc Pediatr Endocrinol. 2006;11:8-14.
  45. Kim HS. Update of precocious puberty. J Korean Soc Endocrinol. 2008;28(3):165-73.
  46. Cho MS, Suh WS, Park SY, Choi YJ, Lee MH, Cho WK, Cho KS, Park SH, Hahn SH, Jung MH, Suh BK, Lee BC. Factors affecting growth velocity during gonadotropin-releasing hormone agonist treatment in girls with idiopathic central precocious puberty. Ann Pediatr Endocrinol Metab. 2012;17:106-13. https://doi.org/10.6065/apem.2012.17.2.106
  47. Kim EJ, Lim YJ, Lee HS, Hwang JS. The effect of gonadotropin releasing hormone agonist and growth hormone on predicted adult height in girls with precocious puberty. J Korean Soc Pediatr Endocrinol. 2007;12(2):111-8.
  48. Seo JY, Yoon IS, Shin CH, Yang SW. The comparison of predicted adult height change and height gain after gonadotropin-releasing hormone agonist and combined growth hormone treatment in girls with idiopathic central precocious puberty. J Korean Pediatr Soc. 2006;49(3):305-11. https://doi.org/10.3345/kjp.2006.49.3.305
  49. Wang B. Hwangjenaegyeongsomun. Seoul: Daeseong Publishing co. 1989:22.
  50. Kim GB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Yu SA, Lee SY, Lee JY, Lee HJ, Chang GT, Chae JW, Hanm YJ, Han JG. Textbook of pediatrics of oriental medicine. Seoul: Uiseongdang Publishing co. 2010:849-53.

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