Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Effects of Pueraria lobata on Obesity Related Hormones in Rats with Estrogen Deficiency

갈근 추출물이 에스트로겐 결핍 Rat의 비만관련 호르몬에 미치는 영향

  • Baek, Seon-Eun (Department of Obstetrics and Gynecology, College of Korean Medicine, Daejeon University) ;
  • Baek, Ji Yun (College of Korean Medicine, Gachon University) ;
  • Kang, Ki-Sung (College of Korean Medicine, Gachon University) ;
  • Yoo, Jeong-Eun (Department of Obstetrics and Gynecology, College of Korean Medicine, Daejeon University)
  • 백선은 (대전대학교 한의과대학 부인과교실) ;
  • 백지윤 (가천대학교 한의과대학) ;
  • 강기성 (가천대학교 한의과대학) ;
  • 유정은 (대전대학교 한의과대학 부인과교실)
  • Received : 2017.11.13
  • Accepted : 2017.11.29
  • Published : 2017.12.30
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Abstract

Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract on obesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity rat model. They were grouped Normal (sham operation group), Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL (ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels of hormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin were estimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin in estrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradiol and CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin in estrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormones related to energy metabolism. PL extract decreased the serum levels of leptin. PL extract increased the serum levels of estradiol and CCK. These results indicate that PL might have potentials for treatment of obesity and complications during the menopause caused by estrogen-deficiency.

Keywords

References

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