Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Cherry Tomato Supplementation Reduces Cardiovascular Risk

  • Koh, Jong-Ho (Department of Bio-Food Analysis, Bio-campus, Korea Polytechnics College) ;
  • Lim, Young-Hee (Department of Public Health Science (BK21 PLUS Program), Graduate School, Korea University) ;
  • Hwang, Dahyun (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University)
  • Received : 2017.11.09
  • Accepted : 2017.12.12
  • Published : 2017.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Tomatoes are rich in nutrients and have many beneficial advantages on human health. Four cherry tomato supplementation diets (CTSDs) were prepared from the juice and cake of fresh and processed (heat-treated) cherry tomatoes. Rats were fed CTSDs for 28 days and the changes in health indices in the serum were analyzed. CTSDs significantly decreased (P < 0.05) food efficiency ratio compared with the control. CTSD feeding significantly increased (P < 0.05) the high-density lipoprotein cholesterol level compared with the control, which resulted in a significant (P < 0.05) decrease in coronary artery risk index and atherogenic index. Furthermore, CTSD feeding increased serum serotonin level. These results indicate that CTSD shows antihyperlipidemic effect.

Keywords

References

  1. Abbott RD, Wilson PW, Kannel WB, Castelli WP. High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1988. 8: 207-211. https://doi.org/10.1161/01.ATV.8.3.207
  2. Adeneye AA, Adeyemi OO, Agbaje EO. Anti-obesity and antihyperlipidaemic effect of hunteria umbellata seed extract in experimental hyperlipidaemia. Journal of Ethnopharmacology. 2010. 130: 307-314. https://doi.org/10.1016/j.jep.2010.05.009
  3. Alberghina D, Giannetto C, Visser E, Ellis A. Effect of diet on plasma tryptophan and serotonin in trained mares and geldings. Veterinary Record. 2010. 166: 133-136. https://doi.org/10.1136/vr.c502
  4. Barter P. The role of HDL-cholesterol in preventing atherosclerotic disease. European Heart Journal Supplements. 2005. 7: F4-F8. https://doi.org/10.1093/eurheartj/sui036
  5. Berrougui H, Momo CN, Khalil A. Health benefits of high-density lipoproteins in preventing cardiovascular diseases. Journal of Clinical Lipidology. 2012. 6: 524-533. https://doi.org/10.1016/j.jacl.2012.04.004
  6. Bornet F, Brouns F, Tashiro Y, Duvillier V. Nutritional aspects of short-chain fructooligosaccharides: natural occurrence, chemistry, physiology and health implications. Digestive and Liver Disease. 2002. 34: S111-S120. https://doi.org/10.1016/S1590-8658(02)80239-0
  7. Cunniff P. AOAC international: Gaithersburg. 1997.
  8. Duenas M, Hernandez T, Estrella I. Changes in the content of bioactive polyphenolic compounds of lentils by the action of exogenous enzymes. Effect on their antioxidant activity. Food Chemistry. 2007. 101: 90-97. https://doi.org/10.1016/j.foodchem.2005.11.053
  9. Fki I, Bouaziz M, Sahnoun Z, Sayadi S. Hypocholesterolemic effects of phenolic-rich extracts of chemlali olive cultivar in rats fed a cholesterol-rich diet. Bioorganic and Medicinal Chemistry. 2005. 13: 5362-5370. https://doi.org/10.1016/j.bmc.2005.05.036
  10. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A metaanalysis of population-based prospective studies. Journal of Cardiovascular Risk. 1996. 3:213-219.
  11. Hussein L, El-Tohamy M. Vitamin a potency of carrot and spinach carotenes in human metabolic studies. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition. 1990. 60: 229-235.
  12. Ilic D, Misso M. Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: A systematic review. Maturitas. 2012. 72: 269-276. https://doi.org/10.1016/j.maturitas.2012.04.014
  13. Jo SP, Kim JK, Lim YH. Antihyperlipidemic effects of stilbenoids isolated from morus alba in rats fed a high-cholesterol diet. Food and Chemical Toxicology. 2014. 65: 213-218. https://doi.org/10.1016/j.fct.2013.12.040
  14. Kim KY, Park CW, Kim HM, Kang IC, Jeong HJ. Effects of acanthopanax divaricatus var. Albeofructus in mice submitted to protein restriction. Oriental Pharmacy and Experimental Medicine. 2011. 11: 15-23. https://doi.org/10.1007/s13596-011-0005-7
  15. Koh JH, Kim Y, Oh JH. Chemical characterization of tomato juice fermented with bifidobacteria. Journal of Food Science. 2010. 75: 428-432. https://doi.org/10.1111/j.1750-3841.2010.01632.x
  16. Leibowitz SF, Alexander JT. Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biological Psychiatry. 1998. 44: 851-864. https://doi.org/10.1016/S0006-3223(98)00186-3
  17. Mackinnon E, Rao A, Josse R, Rao L. Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker n-telopeptide of type i collagen in postmenopausal women. Osteoporosis International. 2011. 22: 1091-1101. https://doi.org/10.1007/s00198-010-1308-0
  18. Nouri MHK, Abad ANA. Comparative study of tomato and tomato paste supplementation on the level of serum lipids and lipoproteins levels in rats fed with high cholesterol. Iranian Red Crescent Medical Journal. 2013. 15: 287. https://doi.org/10.5812/ircmj.1007
  19. Sato R, Helzlsouer KJ, Alberg AJ, Hoffman SC, Norkus EP, Comstock GW. Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer. Cancer Epidemiology and Prevention Biomarkers. 2002. 11:451-457.
  20. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. Eating disorder and epilepsy in mice lacking 5-ht2c serotonin receptors. Nature. 1995. 374: 542-546. https://doi.org/10.1038/374542a0