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HMQC vs HSQC for Small Molecules

  • Kim, Eunhee (Protein Structure Group, Korea Basic Science Institute) ;
  • Cheong, Hae-Kap (Protein Structure Group, Korea Basic Science Institute)
  • Received : 2017.08.18
  • Accepted : 2017.11.25
  • Published : 2017.12.20

Abstract

Proton detected Heteronuclear Multiple Quantum Coherence (HMQC) and Heteronuclear Single Quantum Coherence (HSQC) essentially provide the same information - correlation of the chemical shift of the proton to J-coupled hetero nuclei such as $^{13}C$ or $^{15}N$ nuclei. This paper is a practical note for the students who ask which one is better and which methods they use routinely. Artifact suppression using phase cycling and gradient pulses are discussed.

Keywords

References

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