Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Stability of Danggwisu-san (Dangguixu-san) Water Extract, a Herbal Medicine, Under Various Storage Conditions

보관조건에 따른 당귀수산의 성분 변화

  • Do, Ho-Jeong (Department of Korean Rehabilitation Medicine, Jaseng Korean Medicine Hospital) ;
  • Shin, Ye-Sle (Department of Korean Rehabilitation Medicine, Jaseng Korean Medicine Hospital) ;
  • Lee, Jae-Hwan (Department of Korean Rehabilitation Medicine, Jaseng Korean Medicine Hospital) ;
  • Ahn, Yong-Jun (Department of Korean Rehabilitation Medicine, Jaseng Korean Medicine Hospital) ;
  • Ha, In-Hyuk (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Lee, Yoon-Jae (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Mi-Riong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Ko, Won-Il (Department of Korean Rehabilitation Medicine, Jaseng Korean Medicine Hospital) ;
  • Song, Seol-Hee (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Chung, Hwa-Jin (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Lee, In-Hee (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Lee, Jae-Woong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Eun-Jee (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Min-Jeong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation)
  • 도호정 (자생한방병원 한방재활의학과) ;
  • 신예슬 (자생한방병원 한방재활의학과) ;
  • 이재환 (자생한방병원 한방재활의학과) ;
  • 안용준 (자생한방병원 한방재활의학과) ;
  • 하인혁 (자생의료재단 척추관절연구소) ;
  • 이윤재 (자생의료재단 척추관절연구소) ;
  • 김미령 (자생의료재단 척추관절연구소) ;
  • 고원일 (자생한방병원 한방재활의학과) ;
  • 송설희 (자생의료재단 척추관절연구소) ;
  • 정화진 (자생의료재단 척추관절연구소) ;
  • 이인희 (자생의료재단 척추관절연구소) ;
  • 이재웅 (자생의료재단 척추관절연구소) ;
  • 김은지 (자생의료재단 척추관절연구소) ;
  • 김민정 (자생의료재단 척추관절연구소)
  • Received : 2016.09.28
  • Accepted : 2016.10.05
  • Published : 2016.10.31
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Abstract

Objectives Danggwisu-san (Dangguixu-san) is a herbal prescription frequently used to treat pain or swelling caused by contusion. To determine the expiration period through scientific methodology, stability of Danggwisu-san (Dangguixu-san) water extract, a herbal medicine, was examined under various storage conditions and periods. Methods Danggwisu-san (Dangguixu-san) was stored either at room temperature ($23{\pm}2^{\circ}C$), under a refrigerating condition ($4^{\circ}C$) or under a freezing condition ($-18{\pm}2^{\circ}C$) for 0, 1, 2, 3 or 4 weeks and then freeze-dried. Total phenol and total flavonoid amounts were investigated; contents of amygdalin (Prunus persica), paeoniflorin (Paeonia lactiflora), and glycyrrhizin (Glycyrrhiza uralensis) - the marker compounds of Danggwisu-san (Dangguixu-san) - were also analyzed through high performance liquid chromatography (HPLC). Results No significant change in total phenol and total flavonoid amounts was observed under the indicated storage conditions. Moreover, the contents of marker compounds, i.e. amygdalin, paeoniflorin, and glycyrrhizin, did not alter significantly under the indicated conditions, as well. Conclusions Danggwisu-san (Dangguixu-san) was found to be stable up until 4 weeks under the indicated conditions. Further studies on efficacy and long-term stability are warranted to establish the expiration period of Danggwisu-san (Dangguixu-san).

Keywords

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