Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제42권5호
  • /
  • Pages.243-250
  • /
  • 2016
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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C-reactive protein/albumin ratio as prognostic score in oral squamous cell carcinoma

  • Park, Heung-Chul (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Kim, Moon-Young (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Kim, Chul-Hwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
  • 투고 : 2016.04.26
  • 심사 : 2016.08.03
  • 발행 : 2016.10.31
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초록

Objectives: Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). Materials and Methods: This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival. We then compared five inflammation-based prognostic scores, CRP/alb ratio, modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and prognostic nutritional index (PNI), based on receiver operating characteristic (ROC) curves. Results: The optimal cut-off value for the CRP/alb ratio was 0.085. The group with a high CRP/alb ratio had a high TNM clinical stage (P=0.002) and larger primary tumors (P=0.029), with statistically significant differences in lymph node metastasis and distant metastasis. In addition, when the CRP/alb ratio was high, multivariate analysis showed a lower survival rate (P=0.002; hazard ratio=6.078), and the ROC curve showed more outstanding discriminatory ability regarding overall survival compared to other inflammation-based prognostic scores. Conclusion: The CRP/alb ratio can be an independent prognostic factor when predicting prognosis in OSCC and has good prognostic ability.

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  3. Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis vol.40, pp.11, 2018, https://doi.org/10.1002/hed.25324
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  9. Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma vol.11, pp.1, 2016, https://doi.org/10.1038/s41598-021-83362-2
  10. Preoperative C-reactive protein to albumin ratio and oral health in oral squamous cell carcinoma patients vol.21, pp.1, 2016, https://doi.org/10.1186/s12903-021-01516-0