References
- Weinberg GL. Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology 2012; 117: 180-7. https://doi.org/10.1097/ALN.0b013e31825ad8de
- Cao D, Heard K, Foran M, Koyfman A. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med 2015; 48: 387-97. https://doi.org/10.1016/j.jemermed.2014.10.009
- Ok SH, Han JY, Lee SH, Shin IW, Lee HK, Chung YK, et al. Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta. Korean J Anesthesiol 2013; 64: 353-9. https://doi.org/10.4097/kjae.2013.64.4.353
- Ok SH, Han JY, Sung HJ, Yang SM, Park J, Kwon SC, et al. Ropivacaine-induced contraction is attenuated by both endothelial nitric oxide and voltage-dependent potassium channels in isolated rat aortae. Biomed Res Int 2013; 2013: 565271.
- Ok SH, Kwon SC, Kang S, Choi MJ, Sohn JT. Mepivacaine-induced intracellular calcium increase appears to be mediated primarily by calcium influx in rat aorta without endothelium. Korean J Anesthesiol 2014; 67: 404-11. https://doi.org/10.4097/kjae.2014.67.6.404
- Baik JS, Sohn JT, Ok SH, Kim JG, Sung HJ, Park SS, et al. Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent. Can J Physiol Pharmacol 2011; 89: 467-76. https://doi.org/10.1139/y11-046
- Ok SH, Sohn JT, Baik JS, Kim JG, Park SS, Sung HJ, et al. Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels. Anesthesiology 2011; 114: 293-301. https://doi.org/10.1097/ALN.0b013e3182054d22
- Mulroy MF. Systemic toxicity and cardiotoxicity from local anesthetics: incidence and preventive measures. Reg Anesth Pain Med 2002; 27: 556-61.
- Akata T. General anesthetics and vascular smooth muscle: direct actions of general anesthetics on cellular mechanisms regulating vascular tone. Anesthesiology 2007; 106: 365-91. https://doi.org/10.1097/00000542-200702000-00026
- Ok SH, Bae SI, Kwon SC, Park JC, Kim WC, Park KE, et al. Bupivacaine-induced vasodilation is mediated by decreased calcium sensitization in isolated endotheliumdenuded rat aortas precontracted with phenylephrine. Korean J Pain 2014; 27: 229-38. https://doi.org/10.3344/kjp.2014.27.3.229
- Akata T. Cellular and molecular mechanisms regulating vascular tone. Part 1: basic mechanisms controlling cytosolic Ca2+ concentration and the Ca2+-dependent regulation of vascular tone. J Anesth 2007; 21: 220-31. https://doi.org/10.1007/s00540-006-0487-5
- Ok SH, Byon HJ, Kwon SC, Park J, Lee Y, Hwang Y, et al. Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine via attenuated dephosphorylation of myosin phosphatase target subunit 1 in isolated rat aorta. Int J Med Sci 2015; 12: 958-67. https://doi.org/10.7150/ijms.13299
- Sung HJ, Choi MJ, Ok SH, Lee SH, Hwang IJ, Kim HS, et al. Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta. Can J Physiol Pharmacol 2012; 90: 863-72. https://doi.org/10.1139/y2012-067
- Lee HM, Ok SH, Sung HJ, Eun SY, Kim HJ, Lee SH, et al. Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle. Can J Physiol Pharmacol 2013; 91: 285-94. https://doi.org/10.1139/cjpp-2012-0197
- Karaki H. Ca2+ localization and sensitivity in vascular smooth muscle. Trends Pharmacol Sci 1989; 10: 320-5. https://doi.org/10.1016/0165-6147(89)90066-7
- Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522: 177-85. https://doi.org/10.1111/j.1469-7793.2000.t01-2-00177.x
- Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 2001; 22: 32-9. https://doi.org/10.1016/S0165-6147(00)01596-0
- Kitazawa T, Eto M, Woodsome TP, Brautigan DL. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem 2000; 275: 9897-900. https://doi.org/10.1074/jbc.275.14.9897
- Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 2000; 475: 197-200. https://doi.org/10.1016/S0014-5793(00)01654-9
- Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. Crit Care Med 2012; 40: 2431-7. https://doi.org/10.1097/CCM.0b013e3182544f48
- Fettiplace MR, Ripper R, Lis K, Lin B, Lang J, Zider B, et al. Rapid cardiotonic effects of lipid emulsion infusion*. Crit Care Med 2013; 41: e156-62. https://doi.org/10.1097/CCM.0b013e318287f874
- Fettiplace MR, Lis K, Ripper R, Kowal K, Pichurko A, Vitello D, et al. Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release 2015; 198: 62-70. https://doi.org/10.1016/j.jconrel.2014.11.018
- Lee SH, Sung HJ, Ok SH, Yu J, Choi MJ, Lim JS, et al. Lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic doses. Yonsei Med J 2013; 54: 1524-32. https://doi.org/10.3349/ymj.2013.54.6.1524
- Ok SH, Yu J, Lee Y, Cho H, Shin IW, Sohn JT. Lipid emulsion attenuates apoptosis induced by a toxic dose of bupivacaine in H9c2 rat cardiomyoblast cells. Hum Exp Toxicol 2016; 35: 929-37. https://doi.org/10.1177/0960327115608930
- Aumeier C, Kasdorf B, Gruber M, Busse H, Wiese CH, Zink W, et al. Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model. Br J Anaesth 2014; 112: 735-41. https://doi.org/10.1093/bja/aet353
- Zausig YA, Zink W, Keil M, Sinner B, Barwing J, Wiese CH, et al. Lipid emulsion improves recovery from bupivacaineinduced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. Anesth Analg 2009; 109: 1323-6. https://doi.org/10.1213/ane.0b013e3181af7fb3
- McLure HA, Rubin AP. Review of local anaesthetic agents. Minerva Anestesiol 2005; 71: 59-74.
-
Park J, Kim YA, Han JY, Jin S, Ok SH, Sohn JT, et al.
$Lipofundin^{(R)}$ MCT/LCT 20% increase left ventricular systolic pressure in an ex vivo rat heart model via increase of intracellular calcium level. Korean J Anesthesiol 2016; 69: 57-62. https://doi.org/10.4097/kjae.2016.69.1.57 - Ward JP, Knock GA, Snetkov VA, Aaronson PI. Protein kinases in vascular smooth muscle tone--role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol Ther 2004; 104: 207-31. https://doi.org/10.1016/j.pharmthera.2004.08.009
- Neal JM, Bernards CM, Butterworth JF 4th, Di Gregorio G, Drasner K, Hejtmanek MR, et al. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35: 152-61. https://doi.org/10.1097/AAP.0b013e3181d22fcd
- Lee JH, Lee KN, Moon JI. Respiratory arrest during epidural infusion of bupivacaine and morphine. J Korean Pain Soc 1995; 8: 386-9.
- Santos AC, DeArmas PI. Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. Anesthesiology 2001; 95: 1256-64. https://doi.org/10.1097/00000542-200111000-00033
-
Shin IW, Hah YS, Kim C, Park J, Shin H, Park KE, et al. Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by
$Intralipid^{(R)}$ . Int J Biol Sci 2014; 10: 367-76. https://doi.org/10.7150/ijbs.8048 - Christensen KL, Mulvany MJ. Location of resistance arteries. J Vasc Res 2001; 38: 1-12.
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