References
- Archambault, V., Zhao, X., White-Cooper, H., Carpenter, A.T., and Glover, D.M. (2007). Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase. PLoS Genet. 3, e200. https://doi.org/10.1371/journal.pgen.0030200
- Ammosova, T., Yedavalli, V.R., Niu, X., Jerebtsova, M., Van Eynde, A., Beullens, M., Bollen, M., Jeang, K.T., and Nekhai, S. (2011). Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J. Biol. Chem. 286, 3798-3804. https://doi.org/10.1074/jbc.M110.196493
- Baldacchino, S., Saliba, C., Petroni, V., Fenech, A.G., Borg, N., and Grech, G. (2014). Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720. EPMA J. 5, 3. https://doi.org/10.1186/1878-5085-5-3
- Barr, F.A., Sillje, H.H., and Nigg, E.A. (2004). Polo-like kinases and the orchestration of cell division. Nat. Rev. Mol. Cell Biol. 5, 429-440.
- Bollen, M., Peti, W., Ragusa, M.J., and Beullens, M. (2010). The extended PP1 toolkit: designed to create specificity. Trends Biochem. Sci. 35, 450-458. https://doi.org/10.1016/j.tibs.2010.03.002
- Bonnet, J., Coopman, P., and Morris, M.C. (2008). Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis. Cell Cycle 7, 1991-1998. https://doi.org/10.4161/cc.7.13.6095
- Bouchoux, C., and Uhlmann, F. (2011). A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit. Cell 147, 803-814. https://doi.org/10.1016/j.cell.2011.09.047
- Boutros, R., Lobjois, V., and Ducommun, B. (2007). CDC25 phosphatases in cancer cells: key players? Good targets? Nat. Rev. Cancer 7, 495-507. https://doi.org/10.1038/nrc2169
- Boutros, R., Mondesert, O., Lorenzo, C., Astuti, P., McArthur, G., Chircop, M., Ducommun, B., and Gabrielli, B. (2013). CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci. PloS one 8, e67822. https://doi.org/10.1371/journal.pone.0067822
- Brautigan, D.L. (2013). Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling. FEBS J. 280, 324-345. https://doi.org/10.1111/j.1742-4658.2012.08609.x
- Burgess, A., Vigneron, S., Brioudes, E., Labbe, J.C., Lorca, T., and Castro, A. (2010). Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin BCdc2/PP2A balance. Proc. Natl. Acad. Sci. USA 107, 12564-12569. https://doi.org/10.1073/pnas.0914191107
- Calabria, I., Baro, B., Rodriguez-Rodriguez, J.A., Russinol, N., and Queralt, E. (2012). Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif. J. Cell Sci. 125, 2875-2884. https://doi.org/10.1242/jcs.097865
- Castilho, P.V., Williams, B.C., Mochida, S., Zhao, Y., and Goldberg, M.L. (2009). The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol. Biol. Cell 20, 4777-4789. https://doi.org/10.1091/mbc.E09-07-0643
- Cho, H.P., Liu, Y., Gomez, M., Dunlap, J., Tyers, M., and Wang, Y. (2005). The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol. Cell Biol. 25, 4541-4551. https://doi.org/10.1128/MCB.25.11.4541-4551.2005
- Clift, D., Bizzari, F., and Marston, A.L. (2009). Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase. Genes Dev. 23, 766-780. https://doi.org/10.1101/gad.507509
- Cougot, D., Allemand, E., Riviere, L., Benhenda, S., Duroure, K., Levillayer, F., Muchardt, C., Buendia, M.A., and Neuveut, C. (2012). Inhibition of PP1 phosphatase activity by HBx: a mechanism for the activation of hepatitis B virus transcription. Sci. Signal. 5, ra1.
- Cristobal, I., Rincon, R., Manso, R., Madoz-Gurpide, J., Carames, C., del Puerto-Nevado, L., Rojo, F., and Garcia-Foncillas, J. (2014). Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation. Biochim. Biophys. Acta 1842, 1823-1829. https://doi.org/10.1016/j.bbadis.2014.06.032
- De Wulf, P., Montani, F., and Visintin, R. (2009). Protein phosphatases take the mitotic stage. Curr. Opin. Cell Biol. 21, 806-815. https://doi.org/10.1016/j.ceb.2009.08.003
- Deibler, R.W., and Kirschner, M.W. (2010). Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol. Cell 37, 753-767. https://doi.org/10.1016/j.molcel.2010.02.023
- Della Monica, R., Visconti, R., Cervone, N., Serpico, A.F., and Grieco, D. (2015). Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression. eLife 4.
- Dephoure, N., Zhou, C., Villen, J., Beausoleil, S.A., Bakalarski, C.E., Elledge, S.J., and Gygi, S.P. (2008). A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. USA. 105, 10762-10767. https://doi.org/10.1073/pnas.0805139105
- Dohadwala, M., da Cruz e Silva, E.F., Hall, F.L., Williams, R.T., Carbonaro-Hall, D.A., Nairn, A.C., Greengard, P., and Berndt, N. (1994). Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA 91, 6408-6412. https://doi.org/10.1073/pnas.91.14.6408
- Eichhorn, P.J., Creyghton, M.P., and Bernards, R. (2009). Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta 1795, 1-15.
- Foley, E.A., Maldonado, M., and Kapoor, T.M. (2011). Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Nat. Cell Biol. 13, 1265-1271. https://doi.org/10.1038/ncb2327
- Gharbi-Ayachi, A., Labbe, J.C., Burgess, A., Vigneron, S., Strub, J.M., Brioudes, E., Van-Dorsselaer, A., Castro, A., and Lorca, T. (2010). The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science 330, 1673-1677. https://doi.org/10.1126/science.1197048
- Gil-Bernabe, A.M., Romero, F., Limon-Mortes, M.C., and Tortolero, M. (2006). Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase. Mol. Cell. Biol. 26, 4017-4027. https://doi.org/10.1128/MCB.01904-05
- Grallert, A., Boke, E., Hagting, A., Hodgson, B., Connolly, Y., Griffiths, J.R., Smith, D.L., Pines, J., and Hagan, I.M. (2015). A PP1-PP2A phosphatase relay controls mitotic progression. Nature 517, 94-98. https://doi.org/10.1038/nature14019
- Guo, F., Stanevich, V., Wlodarchak, N., Sengupta, R., Jiang, L., Satyshur, K.A., and Xing, Y. (2014). Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res. 24, 190-203. https://doi.org/10.1038/cr.2013.138
- Helps, N.R., Brewis, N.D., Lineruth, K., Davis, T., Kaiser, K., and Cohen, P.T. (1998). Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J. Cell Sci. 111 ( Pt 10), 1331-1340.
- Hoffmann, I., Clarke, P.R., Marcote, M.J., Karsenti, E., and Draetta, G. (1993). Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 12, 53-63.
- Holland, A.J., Bottger, F., Stemmann, O., and Taylor, S.S. (2007). Protein phosphatase 2A and separase form a complex regulated by separase autocleavage. J. Biol. Chem. 282, 24623-24632. https://doi.org/10.1074/jbc.M702545200
- Hunter, T. (1995). Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225-236. https://doi.org/10.1016/0092-8674(95)90405-0
- Izawa, D., and Pines, J. (2015). The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C. Nature 517, 631-634. https://doi.org/10.1038/nature13911
- Izumi, T., and Maller, J.L. (1993). Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol. Biol. Cell 4, 1337-1350. https://doi.org/10.1091/mbc.4.12.1337
- Janssens, V., and Goris, J. (2001). Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439. https://doi.org/10.1042/bj3530417
- Johnson, S.A., and Hunter, T. (2005). Kinomics: methods for deciphering the kinome. Nat. Methods 2, 17-25. https://doi.org/10.1038/nmeth731
- Kelly, A.E., and Funabiki, H. (2009). Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr. Opin. Cell Biol. 21, 51-58. https://doi.org/10.1016/j.ceb.2009.01.004
- Kim, H.S., Baek, K.H., Ha, G.H., Lee, J.C., Kim, Y.N., Lee, J., Park, H.Y., Lee, N.R., Lee, H., Cho, Y., et al. (2010). The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO J. 29, 3544-3557. https://doi.org/10.1038/emboj.2010.217
- Kim, H.S., Kim, S.H., Park, H.Y., Lee, J., Yoon, J.H., Choi, S., Ryu, S.H., Lee, H., Cho, H.S., and Lee, C.W. (2013). Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion. Nat. Commun. 4, 2631. https://doi.org/10.1038/ncomms3631
- Kim, S.H., Jeon, Y., Kim, H.S., Lee, J.K., Lim, H.J., Kang, D., Cho, H., Park, C.K., Lee, H., and Lee, C.W. (2016). Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology 63, 247-259. https://doi.org/10.1002/hep.28281
- Kitajima, T.S., Sakuno, T., Ishiguro, K., Iemura, S., Natsume, T., Kawashima, S.A., and Watanabe, Y. (2006). Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 441, 46-52. https://doi.org/10.1038/nature04663
- Kotwaliwale, C., and Biggins, S. (2006). Microtubule capture: a concerted effort. Cell 127, 1105-1108. https://doi.org/10.1016/j.cell.2006.11.032
- Kumagai, A., and Dunphy, W.G. (1999). Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. Genes Dev. 13, 1067-1072. https://doi.org/10.1101/gad.13.9.1067
- Kumagai, A., Yakowec, P.S., and Dunphy, W.G. (1998). 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol. Biol. Cell 9, 345-354. https://doi.org/10.1091/mbc.9.2.345
- Kruse, T., Zhang, G., Larsen, M.S., Lischetti, T., Streicher, W., Kragh Nielsen, T., Bjorn, S.P., and Nilsson, J. (2013). Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression. J. Cell Sci. 1, 1086-1092.
- Larsen, M., Tremblay, M.L., and Yamada, K.M. (2003). Phosphatases in cell-matrix adhesion and migration. Nat. Rev. Mol. Cell Biol. 4, 700-711.
- Lindqvist, A., Rodriguez-Bravo, V., and Medema, R.H. (2009). The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J. Cell Biol. 185, 193-202. https://doi.org/10.1083/jcb.200812045
- London, N., and Biggins, S. (2014). Signalling dynamics in the spindle checkpoint response. Nature reviews Mol. Cell Biol. 15, 736-747. https://doi.org/10.1038/nrm3888
- Lopez-Aviles, S., Kapuy, O., Novak, B., and Uhlmann, F. (2009). Irreversibility of mitotic exit is the consequence of systems-level feedback. Nature 459, 592-595. https://doi.org/10.1038/nature07984
- Macek, B., Mann, M., and Olsen, J.V. (2009). Global and sitespecific quantitative phosphoproteomics: principles and applications. Ann. Rev. Pharmacol. Toxicol. 49, 199-221. https://doi.org/10.1146/annurev.pharmtox.011008.145606
- Mailand, N., Lukas, C., Kaiser, B.K., Jackson, P.K., Bartek, J., and Lukas, J. (2002). Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat. Cell Biol. 4, 317-322.
- Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002). The protein kinase complement of the human genome. Science 298, 1912-1934. https://doi.org/10.1126/science.1075762
- McCloy, R.A., Parker, B.L., Rogers, S., Chaudhuri, R., Gayevskiy, V., Hoffman, N.J., Ali, N., Watkins, D.N., Daly, R.J., James, D.E., et al. (2015). Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs. Mol. Cell. Proteomics 14, 2194-2212. https://doi.org/10.1074/mcp.M114.046938
- Mehta, G.D., Rizvi, S.M., and Ghosh, S.K. (2012). Cohesin: a guardian of genome integrity. Biochim. Biophys. Acta 1823, 1324-1342. https://doi.org/10.1016/j.bbamcr.2012.05.027
- Meraldi, P., and Nigg, E.A. (2001). Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J. Cell Sci. 114, 3749-3757.
- Mocciaro, A., and Schiebel, E. (2010). Cdc14: a highly conserved family of phosphatases with non-conserved functions? J. Cell Sci. 123, 2867-2876. https://doi.org/10.1242/jcs.074815
- Mochida, S., Ikeo, S., Gannon, J., and Hunt, T. (2009). Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J. 28, 2777-2785. https://doi.org/10.1038/emboj.2009.238
- Mochida, S., Maslen, S.L., Skehel, M., and Hunt, T. (2010). Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science 330, 1670-1673. https://doi.org/10.1126/science.1195689
- Mueller, P.R., Coleman, T.R., and Dunphy, W.G. (1995). Cell cycle regulation of a Xenopus Wee1-like kinase. Mol. Biol. Cell 6, 119-134. https://doi.org/10.1091/mbc.6.1.119
- Musacchio, A., and Salmon, E.D. (2007). The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8, 379-393.
- Nagao, K., and Yanagida, M. (2002). Regulating sister chromatid separation by separase phosphorylation. Dev. Cell 2, 2-4. https://doi.org/10.1016/S1534-5807(01)00112-5
- Nilsson, I., and Hoffmann, I. (2000). Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell Cycle Res. 4, 107-114.
- O'Farrell, P.H. (2001). Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 11, 512-519. https://doi.org/10.1016/S0962-8924(01)02142-0
- Olsen, J.V., Blagoev, B., Gnad, F., Macek, B., Kumar, C., Mortensen, P., and Mann, M. (2006). Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-648. https://doi.org/10.1016/j.cell.2006.09.026
- Olsen, J.V., Vermeulen, M., Santamaria, A., Kumar, C., Miller, M.L., Jensen, L.J., Gnad, F., Cox, J., Jensen, T.S., Nigg, E.A., et al. (2010). Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. 3, ra3.
- Perdiguero, E., and Nebreda, A.R. (2004). Regulation of Cdc25C activity during the meiotic G2/M transition. Cell cycle 3, 733-737.
- Peters, J.M., Tedeschi, A., and Schmitz, J. (2008). The cohesin complex and its roles in chromosome biology. Genes Dev. 22, 3089-3114. https://doi.org/10.1101/gad.1724308
- Pomerening, J.R., Sontag, E.D., and Ferrell, J.E., Jr. (2003). Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat. Cell Biol. 5, 346-351. https://doi.org/10.1038/ncb954
- Potapova, T.A., Daum, J.R., Pittman, B.D., Hudson, J.R., Jones, T.N., Satinover, D.L., Stukenberg, P.T., and Gorbsky, G.J. (2006). The reversibility of mitotic exit in vertebrate cells. Nature 440, 954-958. https://doi.org/10.1038/nature04652
- Queralt, E., and Uhlmann, F. (2008). Cdk-counteracting phosphatases unlock mitotic exit. Curr. Opin. Cell Biol. 20, 661-668. https://doi.org/10.1016/j.ceb.2008.09.003
- Rogers, S., Fey, D., McCloy, R.A., Parker, B.L., Mitchell, N.J., Payne, R.J., Daly, R.J., James, D.E., Caldon, C.E., Watkins, D.N., et al. (2016). PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. J. Cell Sci. 129, 1340-1354. https://doi.org/10.1242/jcs.179754
- Ruchaud, S., Carmena, M., and Earnshaw, W.C. (2007). Chromosomal passengers: conducting cell division. Nat. Rev. Mol. Cell Biol. 8, 798-812. https://doi.org/10.1038/nrm2257
- Sassoon, I., Severin, F.F., Andrews, P.D., Taba, M.R., Kaplan, K.B., Ashford, A.J., Stark, M.J., Sorger, P.K., and Hyman, A.A. (1999). Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 13, 545-555. https://doi.org/10.1101/gad.13.5.545
- Schlaitz, A.L., Srayko, M., Dammermann, A., Quintin, S., Wielsch, N., MacLeod, I., de Robillard, Q., Zinke, A., Yates, J.R., 3rd, Muller-Reichert, T., et al. (2007). The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell 128, 115-127. https://doi.org/10.1016/j.cell.2006.10.050
- Schmitz, M.H., Held, M., Janssens, V., Hutchins, J.R., Hudecz, O., Ivanova, E., Goris, J., Trinkle-Mulcahy, L., Lamond, A.I., Poser, I., et al. (2010). Live-cell imaging RNAi screen identifies PP2AB55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat. Cell Biol. 12, 886-893. https://doi.org/10.1038/ncb2092
- Seshacharyulu, P., Pandey, P., Datta, K., and Batra, S.K. (2013). Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Letters 335, 9-18. https://doi.org/10.1016/j.canlet.2013.02.036
- Shi, Y. (2009). Serine/threonine phosphatases: mechanism through structure. Cell 139, 468-484. https://doi.org/10.1016/j.cell.2009.10.006
- Sivakumar, S., Janczyk, P.L., Qu, Q., Brautigam, C.A., Stukenberg, P.T., Yu, H., and Gorbsky, G.J. (2016). The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. eLife 5.
- Stebbing, J., Lit, L.C., Zhang, H., Darrington, R.S., Melaiu, O., Rudraraju, B., and Giamas, G. (2014). The regulatory roles of phosphatases in cancer. Oncogene 33, 939-953. https://doi.org/10.1038/onc.2013.80
- Suijkerbuijk, S. J. E., Vleugel, M., Teixeira, A., and Kops, G. J. P. L.(2012). Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev. Cell 23, 745-755. https://doi.org/10.1016/j.devcel.2012.09.005
- Sullivan, M., and Morgan, D.O. (2007). Finishing mitosis, one step at a time. Nat. Rev. Mol. Cell Biol. 8, 894-903. https://doi.org/10.1038/nrm2276
- Sumiyoshi, E., Sugimoto, A., and Yamamoto, M. (2002). Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. J. Cell Sci. 115, 1403-1410.
- Takakura, S., Kohno, T., Manda, R., Okamoto, A., Tanaka, T., and Yokota, J. (2001). Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Internat. J. Oncology 18, 817-824.
- Tan, S., Lyulcheva, E., Dean, J., and Bennett, D. (2008). Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability. J. Cell Biol. 182, 27-33. https://doi.org/10.1083/jcb.200712080
- Tan-Wong, S.M., Zaugg, J.B., Camblong, J., Xu, Z., Zhang, D.W., Mischo, H.E., Ansari, A.Z., Luscombe, N.M., Steinmetz, L.M., and Proudfoot, N.J. (2012). Gene loops enhance transcriptional directionality. Science 338, 671-675. https://doi.org/10.1126/science.1224350
- Tang, Z., Shu, H., Qi, W., Mahmood, N.A., Mumby, M.C., and Yu, H. (2006). PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev. Cell 10, 575-585. https://doi.org/10.1016/j.devcel.2006.03.010
- Tonks, N.K. (2006). Protein tyrosine phosphatases: from genes, to function, to disease. Nat. Rev. Mol. Cell Biol. 7, 833-846.
- Trinkle-Mulcahy, L., and Lamond, A.I. (2006). Mitotic phosphatases:no longer silent partners. Curr. Opin. Cell Biol. 18, 623-631. https://doi.org/10.1016/j.ceb.2006.09.001
- Vigneron, S., Brioudes, E., Burgess, A., Labbe, J.C., Lorca, T., and Castro, A. (2009). Greatwall maintains mitosis through regulation of PP2A. EMBO J. 28, 2786-2793. https://doi.org/10.1038/emboj.2009.228
- Virshup, D.M., and Shenolikar, S. (2009). From promiscuity to precision: protein phosphatases get a makeover. Mol. Cell 33, 537-545. https://doi.org/10.1016/j.molcel.2009.02.015
- Visintin, R., Hwang, E.S., and Amon, A. (1999). Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398, 818-823. https://doi.org/10.1038/19775
- Voets, E., and Wolthuis, R.M. (2010). MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis. Cell Cycle 9, 3591-3601. https://doi.org/10.4161/cc.9.17.12832
- Waizenegger, I.C., Hauf, S., Meinke, A., and Peters, J.M. (2000). Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell 103, 399-410. https://doi.org/10.1016/S0092-8674(00)00132-X
- Werner-Allen, J.W., Lee, C.J., Liu, P., Nicely, N.I., Wang, S., Greenleaf, A.L., and Zhou, P. (2011). cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. J. Biol. Chem. 286, 5717-5726. https://doi.org/10.1074/jbc.M110.197129
- Winkler, C., De Munter, S., Van Dessel, N., Lesage, B., Heroes, E., Boens, S., Beullens, M., Van Eynde, A., and Bollen, M. (2015). The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth. J. Cell Sci. 128, 4526-4537. https://doi.org/10.1242/jcs.175588
- Wu, J.Q., Guo, J.Y., Tang, W., Yang, C.S., Freel, C.D., Chen, C., Nairn, A.C., and Kornbluth, S. (2009). PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat. Cell Biol. 11, 644-651. https://doi.org/10.1038/ncb1871
- Xiang, K., Nagaike, T., Xiang, S., Kilic, T., Beh, M.M., Manley, J.L., and Tong, L. (2010). Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature 467, 729-733. https://doi.org/10.1038/nature09391
- Xing, H., Vanderford, N.L., and Sarge, K.D. (2008). The TBP-PP2A mitotic complex bookmarks genes by preventing condensin action. Nat. Cell Biol. 10, 1318-1323. https://doi.org/10.1038/ncb1790
- Yang, Q., and Ferrell, J.E., Jr. (2013). The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat. Cell Biol. 15, 519-525. https://doi.org/10.1038/ncb2737
- Yellman, C.M., and Burke, D.J. (2006). The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae. Mol. Biol. Cell 17, 658-666. https://doi.org/10.1091/mbc.e05-04-0336
- Yu, J., Fleming, S.L., Williams, B., Williams, E.V., Li, Z., Somma, P., Rieder, C.L., and Goldberg, M.L. (2004). Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila. J. Cell Biol. 164, 487-492. https://doi.org/10.1083/jcb.200310059
- Zeng, K., Bastos, R.N., Barr, F.A., and Gruneberg, U. (2010). Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J. Cell Biol. 191, 1315-1332. https://doi.org/10.1083/jcb.201008106
Cited by
- Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile 2017, https://doi.org/10.1021/acs.jproteome.7b00364
- phosphatase PP2A interacts with the centrosomal protein CEP161, a CDK5RAP2 ortholog vol.23, pp.10, 2018, https://doi.org/10.1111/gtc.12637
- Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates vol.87, pp.1, 2018, https://doi.org/10.1146/annurev-biochem-062917-012332
- A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I vol.9, pp.2, 2016, https://doi.org/10.3390/cells9020390
- LEM2 phase separation governs ESCRT-mediated nuclear envelope reformation vol.582, pp.7810, 2016, https://doi.org/10.1038/s41586-020-2232-x
- MnTE-2-PyP Suppresses Prostate Cancer Cell Growth via H 2 O 2 Production vol.9, pp.6, 2016, https://doi.org/10.3390/antiox9060490
- Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae vol.10, pp.None, 2016, https://doi.org/10.7554/elife.72833
- Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases vol.22, pp.7, 2021, https://doi.org/10.3390/ijms22073791
- Exploring the thermodynamic, kinetic and inhibitory mechanisms of 5-iTU targeting mitotic kinase haspin by integrated molecular dynamics vol.23, pp.34, 2021, https://doi.org/10.1039/d1cp02783b