Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
권호 표지
DOI QR코드

DOI QR Code

Usefulness of 18F-Florbetaben in Alzheimer's Disease Diagnosis

알츠하이머병 진단에서 18F-Florbetaben의 유용성

  • Lee, Hyo-Yeong (Department of Radiological Science, Dong Eui University) ;
  • Im, In-Chul (Department of Radiological Science, Dong Eui University) ;
  • Song, Min-jae (Department of Nuclear Medicine, Inje University Busan Paik Hospital) ;
  • Shin, Seong-gyu (Department of Radiology, Dong-A University Hospital)
  • 이효영 (동의대학교 방사선학과) ;
  • 임인철 (동의대학교 방사선학과) ;
  • 송민재 (인제대학교 부산백병원 핵의학과) ;
  • 신성규 (동아대학교병원 영상의학과)
  • Received : 2016.06.13
  • Accepted : 2016.08.31
  • Published : 2016.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Alzheimer's disease is the most common degenerative brain diseases that causes dementia. ${\beta}$-amyloid neuritic plaque density that accumulates in the brain is difficult to perform daily living, such as memory loss, language ability deterioration. It is used to estimate ${\beta}$-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive impairment. Using the $^{18}F$-Florbetaben with high sensitivity and specificity for the ${\beta}$-amyloid neuritic plaque density to evaluate the usefulness for the early diagnosis of Alzheimer's disease. In $^{18}F$-FDG Brain imaging shows no specific findings. And it appeared on the MR-Brain imaging without atrophy of the hippocampus. However, the intake of ${\beta}$-amyloid neuritic plaque density in $^{18}F$-Florbetaben informs that it is the progress of Alzheimer's disease. Therefore, $^{18}F$-Florobetaben is very useful for early diagnosis of Alzheimer's disease.

알츠하이머병은 치매를 일으키는 가장 흔한 퇴행성 뇌 질환이다. 뇌에 축적되는 베타 아밀로이드 단백질은 기억력감퇴, 언어능력 저하등 일상생활 수행 능력이 어렵게 된다. 베타 아밀로이드 플라그 농도는 인지장애를 가진 성인환자에서 알츠하이머 질환과 인지장애의 다른 원인인지를 평가하는 데 사용된다. 베타아밀로이드 단백질에 대한 높은 민감성과 특이성을 가진 $^{18}F$-Florbetaben을 이용하여 알츠하이머병을 조기진단에 유용성을 알아보고자 한다. $^{18}F$-FDG Brain 영상에서 특이소견 없음을 보인다. 그리고 MR-Brain 영상에서 해마의 위축이 없는 것으로 보였다. 하지만 $^{18}F$-Florobetaben에서 베타 아밀로이드의 섭취는 알츠하이머병의 진전이 되고 있음을 알려준다. 따라서, $^{18}F$-Florobetaben은 알츠하이머병을 조기 진단하는 데 매우 유용하다.

Keywords

References

  1. E. Basar, B. Guntekin. A review of brain oscillations in cognitive disorders and the role of eurotransmitters. Brain Res vol 1235, pp. 172-193. 2008 https://doi.org/10.1016/j.brainres.2008.06.103
  2. C. P. Ferri, M. Prince, C. Brayne, H. Brodaty, L. Fratiglioni, M. Ganguli, et al. Global prevalence of dementia: a Delphi consensus study. Lancet., vol. 17, pp. 366:2112-7. 2005 https://doi.org/10.1016/S0140-6736(05)67889-0
  3. C. M. Clark, C. DeCarli, D. Mungas, H. I. Chui, R. Higdon, J. Nunez, et al. Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals. Archives Neurology., vol 62, pp. 774-778. 2005 https://doi.org/10.1001/archneur.62.5.774
  4. H. Y. Lee, H. J. Kim, I. C. Im, J. S. Lee, "Correlation between the seoul neuropsychological screening battery of the pakinson's disease patient with mild cognitive impairment and change of the cerebral ventricle volume in the brain MRI" J. Korean Scociety Radiology. vol. 8, No. 5, August. 2014
  5. Ministy for Health, Welfare and Family Affairs,"Nationwide Study on the Prevalence of Dementia in Korean Elders", Ministy for Health, Welfare and Family Affairs, 2012
  6. National Health Insurance Service. Press Release. 2015. 09. 14.
  7. M. D. Greicius, G. Srivastava, A. L. Reiss, and V. Menon,"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI.,"
  8. L. D. Wang, M. R. Catherine, Z. Abraham, R. Matthew, B. Jewell, B. A. Thomas, et. al. Alzheimet dissease family history impacts restiong state function connectivity. Process. National. Academy. Sci. U. S. A., vol. 101, no. 13, pp. 4637-42, Mar. 2004. https://doi.org/10.1073/pnas.0308627101
  9. D. Y. Lee, E. Fletcher, O. Martinez, M. Ortega, N. Zozulya J. Kim, J. Tran, M. Buonocore, O. Carmichael, and C. DeCarli, "Regional pattern of white matter microstructural changes in normal aging, MCI, and AD.," Neurology, vol. 73, no. 21, pp. 1722-8, Nov. 2009. https://doi.org/10.1212/WNL.0b013e3181c33afb
  10. A. C. van Harten, P. J. Visser, Y. A. Pijnenburg, C. E. Teunissen, M. A. Blankenstein, P. Scheltens, et al. Cerebrospinal fluid $A{\beta}$42 is the best predictor of clinical progression in patients with subjective complaints. Alzheimers Dementia., vol. 9, pp. 481-487. 2013 https://doi.org/10.1016/j.jalz.2012.08.004
  11. Y. S. Shim, Morris JC. Biomarkers predicting Alzheimer's disease in cognitively normal aging. J Clinical Neurology., vol. 7, pp. 60-68. 2011 https://doi.org/10.3988/jcn.2011.7.2.60
  12. A. M. Fagan, C. M. Roe, C. Xiong, M. A. Mintun, J. C. Morris, D. M. Holtzman. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Archives Neurology, vol. 64 pp. 343-349. 2007 https://doi.org/10.1001/archneur.64.3.noc60123
  13. G. Verdile, S. Fuller, C. S. Atwood, S. M. Laws, S. E. Gandy, R. N. Martins. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacology Research vol. 50, pp. 397-409. 2004 https://doi.org/10.1016/j.phrs.2003.12.028