Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Risk Factors of Deteriorated Voice Quality in Patients Who Underwent Thyroidectomy

갑상선 절제술 후 발생하는 주관적인 음성 기능 저하의 위험 요인에 대한 연구

  • Lee, Hyoung Shin (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Kim, Sung Won (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Park, Chanwoo (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Kim, Chang Hoi (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Kim, Seobin (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Lim, Sujin (Kosin University College of Medicine) ;
  • Lee, Kang Dae (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine)
  • 이형신 (고신대학교 의과대학 이비인후과학교실) ;
  • 김성원 (고신대학교 의과대학 이비인후과학교실) ;
  • 박찬우 (고신대학교 의과대학 이비인후과학교실) ;
  • 김창회 (고신대학교 의과대학 이비인후과학교실) ;
  • 김서빈 (고신대학교 의과대학 이비인후과학교실) ;
  • 임수진 (고신대학교 의과대학 의학과) ;
  • 이강대 (고신대학교 의과대학 이비인후과학교실)
  • Received : 2016.04.18
  • Accepted : 2016.05.19
  • Published : 2016.05.30
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Abstract

Background and Objectives: Quality of voice may be deteriorated after thyroidectomy without any injury to recurrent laryngeal nerve. While there have been several studies showing the change of acoustic parameters after thyroidectomy, factors related to deteriorated voice quality have been rarely studies. In this study, we sought to analyze the factors associated to deteriorated voice quality after thyroidectomy. Materials and Methods: We made a retrospective review of 35 patients who underwent thyroidectomy for papillary thyroid carcinoma. Voice analysis including acoustic analysis, voice handicap index 10 (VHI-10), and GRBAS score was conducted before and 3 months after surgery. Patients were grouped according to the amount of increase in VHI-10 after surgery ; group A (${\Delta}VHI<7$) and group B (${\Delta}VHI{\geq}7$). Clinicopathologic factors associated to patients of group B were analyzed and changes of parameters from acoustic analysis in each group were evaluated. Results : Patients of group B were associated with age ${\geq}45$ years (p=0.025) and showed borderline association to total thyroidectomy (p=0.075) and tumor size ${\geq}1cm$ (p=0.086). Multivariate analysis demonstrated that those with age ${\geq}45$ years were independently associated to deteriorated quality of voice (p=0.014, HR=18.38). Patients of group B were also associated to significant deterioration of high pitch (p<0.001) and Grade score with borderline significance (p=0.054). Conclusion: Patients older than 45 years may have higher risk of deterioration of quality of voice after thyroidectomy based on increase of VHI-10 score (${\Delta}VHI{\geq}7$). Association with deterioration of high pitch should also be considered in these patients.

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References

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