Sleep Medicine and Psychophysiology (수면정신생리)

KOREAN ACADEMY OF SLEEP MEDICINE (대한수면의학회)
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Association of the RORA Gene Polymorphism and Diurnal Preference in a Young Korean Population

RORA 유전자 다형성과 한국인 젊은 성인에서 일중선호도와의 연관성

  • Ju, Hoon (Department of Medicine, Korea University School of Medicine) ;
  • Cho, Chul-Hyun (Department of Psychiatry, Korea University College of Medicine) ;
  • Moon, Joung Ho (Department of Psychiatry, Korea University College of Medicine) ;
  • Kim, Leen (Department of Psychiatry, Korea University College of Medicine) ;
  • Lee, Heon-Jeong (Department of Psychiatry, Korea University College of Medicine)
  • 주훈 (고려대학교 의학전문대학원 의학과) ;
  • 조철현 (고려대학교 의과대학 정신건강의학교실) ;
  • 문정호 (고려대학교 의과대학 정신건강의학교실) ;
  • 김린 (고려대학교 의과대학 정신건강의학교실) ;
  • 이헌정 (고려대학교 의과대학 정신건강의학교실)
  • Received : 2016.06.07
  • Accepted : 2016.06.23
  • Published : 2016.06.30
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Abstract

Objectives: The retinoid-related orphan receptor A (RORA) gene has been reported to have an impact on circadian rhythm regulation. In this study, we analyzed the relationship between the RORA gene polymorphism and diurnal preference in Korean young adults. Methods: A population of 504 young adults was included in the study. All subjects were given and completed a 13-item composite scale for morningness (CSM). The RORA gene rs11071547 single-nucleotide polymorphism (SNP) was genotyped by PCR-based methods. Results: CSM score was not associated with genotype or allele carrier status of the RORA rs11071547 SNP. Conclusion: This result indicates that the RORA rs11071547 SNP does not play a role in diurnal preference.

목 적 : Retinoid-related orphan receptor A (RORA) 유전자가 일주기리듬의 조절에 영향을 미친다는 사실이 알려져 왔다. 본 연구에서는 RORA 유전자다형성과 일중선호도의 연관성을 한국인 젊은 성인을 대상으로 분석하였다. 방 법 : 광고를 통해 모집한 504명의 젊은 성인이 최종적으로 대상에 포함되었다. 모든 대상은 13문항 composite scale for morningness (CSM)를 작성하였다. RORA rs11071547 단일염기다형성은 PCR 기반한 실험 방법을 통하여 분석하였다. 결 과 : CSM 점수결과 일중선호도는 RORA rs11071547 SNP의 유전자형과 대립유전자 보유여부에 따라 차이를 보이지 않았다. 결 론 : 이러한 연구결과는 RORA rs11071547 SNP가 일중선호도에 중요한 역할을 하지 않을 가능성을 보여준다.

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References

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