Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Allium Hookeri Extracts on Glucose Metabolism in Type II Diabetic Mice

당뇨병 마우스(db/db) 모델에서 삼채(Allium Hookeri) 부위별 추출물의 항당뇨 효능 연구

  • Kim, Nam-Seok (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Choi, Bong-Kyoum (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Lee, Seon-Hye (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Jang, Hwan-Hee (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Kim, Jung-Bong (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Kim, Haeng-Ran (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Choe, Jeong-Sook (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Cho, Yong-Sik (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Kim, You-Suk (Microbial Institute for Fermentation Industry) ;
  • Yang, Jae-Heon (Center For Healthcare Technology Development, Chonbuk National University) ;
  • Kim, Young-Soo (Department of Food Science and Technology, Chonbuk National University) ;
  • Kim, Hyun-Ju (Research Department, World Institute of Kimchi) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
  • Lee, Chang-Hyun (College of Korean Medicine, Woosuk University) ;
  • Lee, Sung-Hyen (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration)
  • 김남석 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 최봉겸 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 이선혜 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 장환희 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김정봉 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김행란 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 최정숙 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 조용식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김유석 ((재)발효미생물산업진흥원) ;
  • 양재헌 (전북대학교 헬스케어기술개발사업단) ;
  • 김영수 (전북대학교 식품공학과) ;
  • 김현주 (세계김치연구소) ;
  • 김대근 (우석대학교 약학대학) ;
  • 이창현 (우석대학교 한의학대학) ;
  • 이성현 (농촌진흥청 국립농업과학원 기능성식품과)
  • Received : 2016.04.24
  • Accepted : 2016.06.07
  • Published : 2016.06.30
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Abstract

This study was conducted to verify the potential of Allium hookeri to control blood glucose metabolism in diabetes model. We fed the experimental diets(ALE, ARE) supplemented with the extract of Allium hookeri leaf or root at 1% of diet to the diabetic mice (C57BLKS/J, db/db) for 8 weeks. Hetero and control mice were fed the control diet without any extract of Allium hookeri leaf or root. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. ARE group treated with the root of A. hookeri showed significantly lower blood glucose levels than the Cont group at 120 min in the OGTT. However, HbA1c level was significantly reduced in both ALE and ARE groups, and higher serum insulin levels and increased density of insulin immunoreactive cells compared with the Cont group were found in these 2 groups. Based on these results, A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion and it may be used to prevent and treat diabetic disease.

Keywords

References

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