Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cardiovascular Protective Effects of the n-Butanol Fraction from Glehnia littoralis Fr. Schm. in a High-Fat-Diet Mouse Model and Its Composition

고지방식이 마우스 동물모델에서 갯방풍 부탄올 분획물의 심혈관 보호 효과 및 주요 성분

  • Lim, Hyun-Jin (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Kwon, Hansol (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Cho, Hyun-Woo (Division of Traditional Korean Medicine Resource, National Development Institute of Korean Medicine) ;
  • An, Byeong-Kwan (Division of Traditional Korean Medicine Resource, National Development Institute of Korean Medicine) ;
  • Cho, Jung-Hee (Division of Traditional Korean Medicine Resource, National Development Institute of Korean Medicine) ;
  • Oak, Min-Ho (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Kim, Hyun Jung (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Han, Dong-Sul (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University)
  • 임현진 (목포대학교 약학대학) ;
  • 권한솔 (목포대학교 약학대학) ;
  • 조현우 (한약진흥재단 한약자원본부) ;
  • 안병관 (한약진흥재단 한약자원본부) ;
  • 조정희 (한약진흥재단 한약자원본부) ;
  • 옥민호 (목포대학교 약학대학) ;
  • 김현정 (목포대학교 약학대학) ;
  • 한동설 (목포대학교 약학대학)
  • Received : 2016.02.01
  • Accepted : 2016.03.10
  • Published : 2016.03.31
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Abstract

In our search for natural products affecting blood circulation, the n-butanol fraction from whole plant of Glehnia littoralis Fr. Schm. (GLB) improved blood lipid parameters, and ameliorated obesity in high-fat-diet (HFD)-fed C57BL/6 mouse model. Hyperlipidemia was induced by high-fat-diet for 4 weeks, and then GLB was orally administrated with 400 mg/kg/day for 4 weeks. GLB-treated group showed that the gain in body weight was significantly attenuated, the levels of total cholesterol and triglyceride significantly lowered on blood chemical analysis, and significantly prolonged the mice bleeding time when compared with those of HFD control group. Concomitantly, phytochemical composition of GLB was investigated by HPLC-hyphenated spectroscopy, and two major phenolic compounds, rutin and chlorogenic acid were identified in the GLB. Taken together, these results indicate that GLB has cardiovascular protective effects and could be a natural medicine candidate for the prevention of cardiovascular disease.

Keywords

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