Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway

  • Lee, Kang-Eun (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Heo, Ji-Eun (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Kim, Jeong-Mok (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Hwang, Cheol-Sang (Department of Life Sciences, Pohang University of Science and Technology)
  • Received : 2015.12.07
  • Accepted : 2016.01.14
  • Published : 2016.03.31
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Abstract

Although $N{\alpha}$-terminal acetylation (Nt-acetylation) is a pervasive protein modification in eukaryotes, its general functions in a majority of proteins are poorly understood. In 2010, it was discovered that Nt-acetylation creates a specific protein degradation signal that is targeted by a new class of the N-end rule proteolytic system, called the Ac/N-end rule pathway. Here, we review recent advances in our understanding of the mechanism and biological functions of the Ac/N-end rule pathway, and its crosstalk with the Arg/N-end rule pathway (the classical N-end rule pathway).

Keywords

References

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