Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Variations in radiochemical purity according to temperature of storage and radical scavenger

  • Kim, Deok Ju (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Kim, Min Soo (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Kim, Jin Seok (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Bae, Yeon Gyu (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Sun, Chan Young (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Choi, Seung Jae (Department of Radiological Science, College of Health and Science, Gachon University) ;
  • Lee, Sang-Yoon (Department of Neuroscience, College of Medicine, Gachon University)
  • Received : 2016.11.29
  • Accepted : 2016.12.15
  • Published : 2016.12.30
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Abstract

Radiolysis is the process of decreasing in Radio-Chemical Purity (RCP) of [$^{18}F$]FDG by direct effect and indirect effect of self Radio-activity. The objective of our study was to figure out the ideal conditions which minimize damages of quality of [$^{18}F$]FDG using radical scavenger and controlling temperature of storage.

Keywords

References

  1. Silindir M, Ozer AY. Recently developed radiopharmaceuticals for positron emission tomography (PET). FABAD J Pharm Sci. 2008;33:153-162.
  2. Ong LC, Jin Y, Song IC, Yu S, Zhang K, Chow PKH. 2-[$^{18}F$]-2-deoxy-D-glucose (FDG) uptake in human tumor cells is related to the expression of GLUT-1 and hexokinase II. Acta Radiologica. 2008;49:1145-1153. https://doi.org/10.1080/02841850802482486
  3. 최용, 이정림, 양전자방출단층촬영(Positron Emission Tomography)의 원리와 응용, 대한핵의학기술학회지, 1996;1:26-34.
  4. Almuhaideb A, Papathanasiou N, Bomanji J. 18F-FDG PET/CT imaging in oncology. Ann Saudi med. 2011;31:3-13. https://doi.org/10.4103/0256-4947.75771
  5. 김상태, [$^{18}F$]FDG 방사성의약품의 품질관리에 관한 조사, 영남대학교 임상약학대학원 석사학위논문, 2010. P.3-4.
  6. 김시활 외, 자동합성장치에 따른 [$^{18}F$]FDG의 방사선분해 평가, 핵의학기술 2012;16:8-11.
  7. 이성권, [$^{18}F$]FDG에서 방사능 농도에 따른 방사화학적 순도 변화 연구, 부산가톨릭대학교 생명과학대학원 석사학위 논문. 2011. P.21.
  8. Dantas NM, Nascimento JE, Santos-Magalhaes NS, Oliveira ML. Radiolysis of 2-[$^{18}F$]fluoro-2-deoxy-Dglucose ([$^{18}F$] FDG) and the role of ethanol, radioactive concentration and temperature of storage. Appl Radiat Isot. 2013;72:158-162. https://doi.org/10.1016/j.apradiso.2012.10.017
  9. Jacobson MS. Radiolysis of 2-[$^{18}F$]fluoro-2-deoxy-D-glucose ([$^{18}F$]FDG) and the role of ethanol and radioactive concentration. Appl Radiat Isot. 2009;67:990-995. https://doi.org/10.1016/j.apradiso.2009.01.005
  10. Walters LR, Martin KJ, Jacobson MS, Hung JC, Mosman EA. Stability evaluation of [$^{18}F$]FDG at high radioactive concentrations. J Nucl Med Technol. 2012;40:52-56. https://doi.org/10.2967/jnmt.111.097287
  11. Fawdry RM. Radiolysis of 2-[$^{18}F$]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers. Appl Radiat Isot. 2007;65:1193-1201. https://doi.org/10.1016/j.apradiso.2007.05.011