Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Improved Manufacturing Method of Discoidal Nanoparticles for Cancer Theranostics

암 진단 및 치료용 디스크 나노 입자의 향상된 입자 생산법에 관한 연구

  • BAE, J.Y. (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • OH, E.S. (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • LEE, H. (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • KEY, Jaehong (Department of Biomedical Engineering, College of Health Sciences, Yonsei University)
  • 배장열 (연세대학교 보건과학대학 의공학부) ;
  • 오은설 (연세대학교 보건과학대학 의공학부) ;
  • 이현 (연세대학교 보건과학대학 의공학부) ;
  • 기재홍 (연세대학교 보건과학대학 의공학부)
  • Received : 2016.01.06
  • Accepted : 2016.02.19
  • Published : 2016.02.29
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Abstract

Nanoparticles have been studied as therapeutic and imaging agents for the early detection and cure of cancer, Cancer Theranostics. Nanoparticles were considered to effectively target cancer cells due to Enhanced Permeability and Retention (EPR) effect and most nanoparticles have been evaluated by using spherical shapes. However, the problem that the EPR effect is not so effective for human cancer therapy was recently brought up. Therefore, in this study, we suggest novel discoidal nanoparticles to overcome this problem, focusing on their manufacturing process and quality control. Herein, we demonstrate the improved manufacturing method of discoidal nanoparticles and their potential to apply to MCF 7, human breast cancer treatment.

나노 입자는 암의 조기 진단과 효과적인 치유를 위한 약물 전달체 또는 영상 조영제로 연구개발 되어왔다. 이러한 나노 입자는 주로 EPR effect로 인해 효과적으로 암 세포를 표적하는 것이 가능하다고 보고되었고, 주로 구형의 나노 입자들이 이러한 실험에 적용되었다. 그러나 최근 EPR effect가 사람의 암 치료에 있어서는 큰 효과를 나타내지 않는다는 한계점이 여러 연구를 통해 제시되고 있다. 따라서 본 연구에서는 이러한 구형 나노 입자의 한계점을 극복하기 위한 새로운 형태의 디스크 나노 입자를 제안하고, 디스크 나노 입자의 생산 과정과 입자의 질을 향상시키기 위한 입자 생산방법에 관한 연구 내용을 보고하였다. 본 연구를 통해 생산된 디스크 나노 입자는 인간 유방암인 MCF7 세포에 적용하여 항암제 전달체로써의 가능성을 평가하였다.

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References

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