Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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The Anti-osteoporosis Effects of Cassia tora L. Seed Ethanol Extract in Ovariectomixed Rats

결명자 주정추출물의 난소적출 랫드에서 항골다공증 효과

  • Lee, Mu-Jin (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • An, Byeong-Kwan (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Jung, Ho-Kyung (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Lee, Ki-Ho (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Kim, A-Hyeon (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Lee, Hyun-Joo (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Jang, Ji-Hun (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Sim, Mi-Ok (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Kim, Tae-Muk (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Kim, Min-Suk (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Seong, Tea-Gyeong (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Woo, Kyeong-Wan (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Cho, Jung-Hee (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine) ;
  • Kim, Jong-Choon (College of Veterinary Medicine BK21 Plus Project Team, Chonnam National University) ;
  • Cho, Hyun-Woo (Division of Tradition Korean Medicine Research, National Development Institute of Korean Medicine)
  • 이무진 (한약진흥재단 한약자원본부) ;
  • 안병관 (한약진흥재단 한약자원본부) ;
  • 정호경 (한약진흥재단 한약자원본부) ;
  • 이기호 (한약진흥재단 한약자원본부) ;
  • 김아현 (한약진흥재단 한약자원본부) ;
  • 이현주 (한약진흥재단 한약자원본부) ;
  • 장지훈 (한약진흥재단 한약자원본부) ;
  • 심미옥 (한약진흥재단 한약자원본부) ;
  • 김태묵 (한약진흥재단 한약자원본부) ;
  • 김민석 (한약진흥재단 한약자원본부) ;
  • 성태경 (한약진흥재단 한약자원본부) ;
  • 우경완 (한약진흥재단 한약자원본부) ;
  • 조정희 (한약진흥재단 한약자원본부) ;
  • 김종춘 (전남대학교 수의과대학 BK21) ;
  • 조현우 (한약진흥재단 한약자원본부)
  • Received : 2016.10.14
  • Accepted : 2016.12.16
  • Published : 2016.12.30
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Abstract

In our study, osteoporosis was induced by ovariectomized in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined by using the experimental substance Cassia tora (CT) ethanol extracts. Female rats were either sham-operated (sham; n=5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride (RLX) 1 mg/kg/day, or CT (20 and 200 mg/kg/day) for 12 weeks. Serum osteocalcin and creatinine concentration were significantly lower in the CT 200 mg/kg/day group compared with the OVX control group. Serum progesterone concentration was significantly higher in the CT 200 mg/kg/day group compared with the OVX control group. Reduction grade of the trabecular bone decreased in the RLX 1 and CT 200 mg/kg/day group compared with that of the OVX control group. In conclusion, CT 200 mg/kg/day may have inhibitory effects on osteoporosis in OVX rats.

Keywords

References

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