Molecules and Cells

  • 제39권2호
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  • Pages.87-95
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  • 2016
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Sirt1 and the Mitochondria

  • Tang, Bor Luen (Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore)
  • 투고 : 2015.11.24
  • 심사 : 2015.12.31
  • 발행 : 2016.02.29
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⟨ 이전 논문 다음 논문 ⟩

초록

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-$1{\alpha}$ (PGC-$1{\alpha}$) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1's role in caloric restriction and impacts on longevity. The notion of Sirt1's regulation of PGC-$1{\alpha}$ activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1's regulation of mitochondrial biogenesis and turnover, in relation to PGC-$1{\alpha}$ deacetylation and various aspects of cellular physiology and disease.

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참고문헌

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  63. Calcitonin Gene-Related Peptide Attenuates LPS-Induced Acute Kidney Injury by Regulating Sirt1 vol.26, pp.None, 2016, https://doi.org/10.12659/msm.923900
  64. Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain vol.17, pp.13, 2016, https://doi.org/10.7150/ijms.46696
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  66. Accelerated Kidney Aging in Diabetes Mellitus vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/1234059
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  89. CD38: T Cell Immuno-Metabolic Modulator vol.9, pp.7, 2016, https://doi.org/10.3390/cells9071716
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  91. Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis vol.40, pp.4, 2016, https://doi.org/10.1080/10799893.2020.1738483
  92. Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc‐1α expression: Follow‐up to an in vitro magnetic mitohormetic study vol.34, pp.8, 2016, https://doi.org/10.1096/fj.201903005rr
  93. The Effect of Resveratrol on Mitochondrial Function in Myoblasts of Patients with the Common m.3243A>G Mutation vol.10, pp.8, 2020, https://doi.org/10.3390/biom10081103
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  96. Insights into the Role of microRNAs in Colorectal Cancer (CRC) Metabolism vol.12, pp.9, 2020, https://doi.org/10.3390/cancers12092462
  97. Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs vol.25, pp.17, 2020, https://doi.org/10.3390/molecules25173849
  98. Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin vol.10, pp.10, 2016, https://doi.org/10.3390/biom10101394
  99. Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection vol.21, pp.21, 2020, https://doi.org/10.3390/ijms21217833
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  102. Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction vol.39, pp.21, 2020, https://doi.org/10.15252/embj.2019103420
  103. Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice vol.10, pp.None, 2016, https://doi.org/10.1038/s41598-020-58214-0
  104. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch vol.10, pp.None, 2016, https://doi.org/10.1038/s41598-020-58999-0
  105. Anomalous AMPK-regulated angiotensin AT 1 R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure vol.27, pp.1, 2016, https://doi.org/10.1186/s12929-020-00660-z
  106. Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs vol.19, pp.None, 2020, https://doi.org/10.1186/s12933-020-01041-4
  107. Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and Challenges vol.78, pp.6, 2016, https://doi.org/10.1097/fjc.0000000000001154
  108. Susceptibility to COVID‐19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants vol.35, pp.1, 2016, https://doi.org/10.1002/jbt.22626
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  110. Study of calcitriol anti-aging effects on human natural killer cells in vitro vol.12, pp.1, 2021, https://doi.org/10.1080/21655979.2021.1972076
  111. Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition vol.320, pp.1, 2016, https://doi.org/10.1152/ajpgi.00203.2020
  112. The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/4993452
  113. SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury vol.14, pp.None, 2016, https://doi.org/10.2147/jir.s300997
  114. SIRT1 Activation Attenuates the Cardiac Dysfunction Induced by Endothelial Cell-Specific Deletion of CRIF1 vol.9, pp.1, 2016, https://doi.org/10.3390/biomedicines9010052
  115. Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/5597394
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  117. Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis vol.8, pp.None, 2016, https://doi.org/10.3389/fnut.2021.635232
  118. Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease vol.13, pp.None, 2016, https://doi.org/10.3389/fnagi.2021.617588
  119. MicroRNAs as Potential Orchestrators of Alzheimer's Disease-Related Pathologies: Insights on Current Status and Future Possibilities vol.13, pp.None, 2016, https://doi.org/10.3389/fnagi.2021.743573
  120. Sodium-Glucose Cotransporter 2 Inhibitors Work as a “Regulator” of Autophagic Activity in Overnutrition Diseases vol.12, pp.None, 2016, https://doi.org/10.3389/fphar.2021.761842
  121. The Dawn of Mitophagy: What Do We Know by Now? vol.19, pp.2, 2016, https://doi.org/10.2174/1570159x18666200522202319
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  123. Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology vol.28, pp.3, 2021, https://doi.org/10.1007/s43032-020-00328-x
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  128. 13C Metabolic Flux Analysis Indicates Endothelial Cells Attenuate Metabolic Perturbations by Modulating TCA Activity vol.11, pp.4, 2021, https://doi.org/10.3390/metabo11040226
  129. SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Postinfarct Nonhuman Primate Hearts vol.30, pp.7, 2016, https://doi.org/10.1089/scd.2020.0149
  130. Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats vol.13, pp.8, 2016, https://doi.org/10.18632/aging.202907
  131. Nicotinamide ameliorates energy deficiency and improves retinal function in Cav‐1‐/‐ mice vol.157, pp.3, 2016, https://doi.org/10.1111/jnc.15266
  132. Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation vol.42, pp.5, 2016, https://doi.org/10.1038/s41401-020-0487-2
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  139. miR34a: a novel small molecule regulator with a big role in bronchopulmonary dysplasia vol.321, pp.1, 2016, https://doi.org/10.1152/ajplung.00279.2020
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  147. Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis vol.18, pp.1, 2016, https://doi.org/10.1186/s12950-021-00296-2
  148. RETRACTED ARTICLE: MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway vol.12, pp.1, 2021, https://doi.org/10.1186/s13287-021-02183-2
  149. Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health vol.10, pp.12, 2021, https://doi.org/10.3390/antiox10121893
  150. Potential Health Benefits of Whole Grains: Modulation of Mitochondrial Biogenesis and Energy Metabolism vol.69, pp.47, 2021, https://doi.org/10.1021/acs.jafc.1c05527
  151. Protective Effect of Sirt1 against Radiation-Induced Damage vol.196, pp.6, 2016, https://doi.org/10.1667/rade-20-00139.1
  152. Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome vol.61, pp.22, 2021, https://doi.org/10.1080/10408398.2020.1809344
  153. Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function vol.21, pp.1, 2022, https://doi.org/10.1002/rmb2.12428
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  155. Mitochondrial homeostasis and redox status in cardiovascular diseases: Protective role of the vagal system vol.178, pp.None, 2022, https://doi.org/10.1016/j.freeradbiomed.2021.12.255
  156. Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function vol.76, pp.1, 2016, https://doi.org/10.1016/j.jhep.2021.09.008
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  158. Bicalutamide Exhibits Potential to Damage Kidney via Destroying Complex I and Affecting Mitochondrial Dynamics vol.11, pp.1, 2022, https://doi.org/10.3390/jcm11010135
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