Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Distribution and Features of the Six Classes of Peroxiredoxins

  • Poole, Leslie B. (Department of Biochemistry, Wake Forest School of Medicine) ;
  • Nelson, Kimberly J. (Department of Biochemistry, Wake Forest School of Medicine)
  • Received : 2015.12.06
  • Accepted : 2015.12.09
  • Published : 2016.01.31
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Abstract

Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ~3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).

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References

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