Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Advances in the Development and Validation of Test Methods in the United States

  • Casey, Warren M. (NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), Interagency Coordinating Committee on the Validation of Alternative Toxicological Methods (ICCVAM), Division of the National Toxicology Program, National Institute of Environmental Health Sciences)
  • Received : 2015.10.23
  • Accepted : 2016.01.07
  • Published : 2016.01.15
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Abstract

The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) provides validation support for US Federal agencies and the US Tox21 interagency consortium, an interagency collaboration that is using high throughput screening (HTS) and other advanced approaches to better understand and predict chemical hazards to humans and the environment. The use of HTS data from assays relevant to the estrogen receptor signaling data pathway is used as an example of how HTS data can be combined with computational modeling to meet the needs of US agencies. As brief summary of US efforts in the areas of biologics testing, acute toxicity, and skin sensitization will also be provided.

Keywords

References

  1. ICCVAM. (2000) Authorization Act of 2000. ICCVAM, 42, 106-545.
  2. Birnbaum, L.S. (2013) 15 years out: reinventing ICCVAM. Environ. Health Perspect., doi:10.1289/ehp.1206292.
  3. National Academy of Sciences. (2007) Board on environmental studies and toxicology. Toxicity testing in the 21st century: a vision and a strategy. The National Academies Press, Washington DC.
  4. Browne, P., Judson, R.S., Casey, W.M., Kleinstreuer, N.C. and Thomas, R. (2015) Screening chemicals for estrogen receptor bioactivity using a computational model. Environ. Sci. Technol., 49, 8804-8814. https://doi.org/10.1021/acs.est.5b02641
  5. Judson, R.S., Magpantay, F.M., Chickarmane, V., Haskell, C., Tania, N., Taylor, J., Xia, M., Huang, R., Rotroff, D.M., Filer, D.L., Houck, K.A., Martin, M.T., Sipes, N., Richard, A.M., Mansouri, K., Setzer, R.W., Knudsen, T.B., Croffon, K.M. and Thomas, R.S. (2015) Integrated model of chemical perturbations of a biological pathway using 18 in vitro high throughput screening assays for the estrogen receptor. Toxicol. Sci., 148, 137-154. https://doi.org/10.1093/toxsci/kfv168
  6. Kleinstreuer, N.C., Ceger, P.C., Allen, D.G., Strickland, J., Chang, X., Hamm, J.T. and Casey, W.M. (2015) A curated database of rodent uterotrophic bioactivity. Environ. Health Perspect., doi:10.1289/ehp.1510183.
  7. Dix, D.J., Houck, K.A., Martin, M.T., Richard, A.M., Setzer, R.W. and Kavlock, R.J. (2007) The toxcast program for prioritizing toxicity testing of environmental chemicals. Toxicol. Sci., 95, 5-12. https://doi.org/10.1093/toxsci/kfl103
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