Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction

천식 소아에서 혈중 포스포리파제 A2: leptin과 운동유발 기관지과민성과의 상관성

  • You, Jueng-Sup (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Choi, Won-Bok (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Yi, Yoon-Young (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Jeong, Soo-In (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Song, Joon-Sup (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Yang, Seong (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Hwang, Il-Tae (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital) ;
  • Lee, Ha-Baik (Department of Pediatrics, Hanyang University College of Medicine) ;
  • Baek, Hey-Sung (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital)
  • 유정섭 (한림대학교 강동성심병원 소아청소년과) ;
  • 최원복 (한림대학교 강동성심병원 소아청소년과) ;
  • 이윤영 (한림대학교 강동성심병원 소아청소년과) ;
  • 정수인 (한림대학교 강동성심병원 소아청소년과) ;
  • 송준섭 (한림대학교 강동성심병원 소아청소년과) ;
  • 양승 (한림대학교 강동성심병원 소아청소년과) ;
  • 황일태 (한림대학교 강동성심병원 소아청소년과) ;
  • 이하백 (한양대학교 소아과학교실) ;
  • 백혜성 (한림대학교 강동성심병원 소아청소년과)
  • Published : 20150000
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Abstract

Purpose: Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that serum leptin levels correlate with (EIB) in children with asthma. The aim of this study was to address the relationship between plasma sPLA2/leptin levels and EIB. Methods: Sixty-seven prepubertal children between the ages of 6 and 10 years were included in the study. They were asthmatics with EIB (n=25), asthmatics without EIB (n=21), and healthy subjects (n=21). We measured the plasma sPLA2 and leptin levels. We also performed pulmonary function tests at baseline, after bronchodilator inhalation, and after exercise. Results: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in those without and control subjects. In addition, sPLA2 levels were significantly correlated with body mass index (Speraman correlation coefficient r=0.343, P=0.023) and leptin levels (partial correlation coefficient r=318, P=0.033). The maximum decrease in % forced expiratory volume in 1 second after exercise was significantly correlated with both PLA2 levels (r=0.301, P=0.041) and leptin levels (r=0.346, P=0.018). Conclusion: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in asthmatics without EIB and control subjects. In addition, sPLA2 levels were significantly correlated with leptin levels and EIB in asthmatic children.

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