Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Medetomidine and Combination of Medetomidine/tiletamine/zolazepam and Medetomidine/tiletamine/zolazepam/tramadol on Echocardiographic Cardiac Contractility in Dogs

개에서 Medetomidine, Medetomidine/tiletamine/zolazepam 합제, Medetomidine/tiletamine/zolazepam/tramadol 합제가 심장초음파 상 심장 수축력에 미치는 영향

  • Suh, Sang-IL (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University) ;
  • Kim, Tae-Jun (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University) ;
  • Lee, Eun-Chan (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University) ;
  • Hyun, Changbaig (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
  • 서상일 (강원대학교 수의과대학 소동물 내과교실) ;
  • 김태준 (강원대학교 수의과대학 소동물 내과교실) ;
  • 이은찬 (강원대학교 수의과대학 소동물 내과교실) ;
  • 현창백 (강원대학교 수의과대학 소동물 내과교실)
  • Accepted : 2015.10.15
  • Published : 2015.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study evaluated the myocardial performance on echocardiography after the sedation/anesthesia of medetomidine (D), the combination of medetomidine and tiletamine/zolazepam (DZ), and the combination of medetomidine, tiletamine/zolazepam and tramadol (DZT) in Beagle dogs. Ten healthy adult Beagle dogs (weighing $8.6{\pm}1.0kg$) were enrolled in this study. Heart rate (HR), fractional shortening (%FS), left ventricular ejection fraction (%LVEF), stroke volume (SV), cardiac output (CO), left ventricular internal diameter in systole (LVIDs) and left ventricular internal diameter in diastole (LVIDd) using M-mode echocardiography were measured prior to anesthesia, then every 10 min for 60 min. The HR, %FS, %LVEF, SV and CO were significantly decreased during sedation/anesthesia with D, DZ and DZT combination of anesthesia. Although those anesthetic protocols provided acceptable quality of sedation/anesthesia, levels of cardiovascular suppression were substantial and persistent and thus the continuous monitoring on vital signs should be accompanied in any situation. Close attention is required for dogs with pre-existing heart diseases, when those anesthetic protocols were applied.

이번 연구는 비글 개에서 medetomidine(D), medetomidine, tiletamine/zolazepam(DZ) 합제, medetomidine, tiletamine/zolazepam, tramadol(DZT) 합제를 이용한 진정/마취 후 심근 기능을 평가하였다. 10 마리의 건강한 성견 비글(체중 $8.6{\pm}1.0$ kg)를 이번 연구에 사용하였다. M-mode 심장초음파를 사용하여 심박수(HR), 구획단축률(%FS), 좌심실 박출기계수(%LVEF), 박출량(SV), 심박출량(CO), 수축기 좌심실 내강 직경 (LVIDs), 이완기 좌심실 내강 직경(LVIDd)을 마취 전, 그리고 마취 후 10분 간격으로 60분 동안 측정하였다. HR, %FS, %LVEF, SV, CO 는 D, DZ 합제, DZT 합제 로 진정된 동안 심각하게 감소하였다. 이번 실험에 사용된 마취 프로토콜은 사용 가능할 정도의 진정/마취가 이뤄졌지만, 심혈관계 압박의 정도가 심했고 지속적이었고, 따라서, 어떠한 상황에서도 생체지수에 대한 모니터링이 동반되어야 한다. 본 마취 프로토콜은 심장질환을 가지고 있어서 심맥관계 억압의 가능성이 높은 환자에서는 주의해서 사용해야 한다.

Keywords

References

  1. Atkins CE, Curtis MB, McGuirk SM, Kittleson MD, Sato T and Snyder PS. The use of m-mode echocardiography in determining cardiac output in dogs with normal, low, and high output states: comparison to thermodilution method. Vet Radiol Ultrasound 1992; 33: 297-304. https://doi.org/10.1111/j.1740-8261.1992.tb00147.x
  2. Cattet MR, Caulkett NA, Polischuk SC, Ramsay MA. Reversible immobilization of free-ranging polar bears with medetomidine-zolazepam-tiletamine and atipamezole. J Wildl Dis 1997; 33: 611-617. https://doi.org/10.7589/0090-3558-33.3.611
  3. Caulkett NA, Cattet MR. Physiological effects of medetomidine-zolazepam-tiletamine immobilization in black bears. J Wildl Dis 1997; 33: 611-617. https://doi.org/10.7589/0090-3558-33.3.611
  4. de Morais HS, Muir WW3rd. The effects of medetomidine on cardiac contractility in autonomically blocked dogs. Vet Surg 1995; 24: 356-364 https://doi.org/10.1111/j.1532-950X.1995.tb01343.x
  5. Fabio L, Barbara S, Maria MF, Stefano Z, Teresa S, Paolo B. Clinical comparison of medetomidine-butorphanol, medetomidine-midazolam and midazolam-butorphanol for intramuscular premedication in the English bulldog. Ann Fac Medic Vet di Parma 2007; 27: 131-142.
  6. Ferrari L, Turrini G, Rostello C, Guidi A, Casartelli A, Piaia A, Sartori M. Evaluation of two combination of Domitor, Zoletil100, and Euthatal to obtain long-term nonrecovery anesthesia in Spraque-Dawley rats. Am Assoc Lab Ani Sci 2005; 55: 256-264.
  7. Grimm KA, Tranquilli WJ, Gross DR, Sisson DD, Bulmer BJ, Benson GJ, Greene SA, Martin-Jimenez T. Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. Am J Vet Res 2005; 66: 1222-1226. https://doi.org/10.2460/ajvr.2005.66.1222
  8. Hellyer P, Muir WW 3rd, Hubbell JA, Sally J. Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to dogs. Vet Surg 1989; 18: 160-165. https://doi.org/10.1111/j.1532-950X.1989.tb01063.x
  9. Ko JC, Payton M, Weil AB, Kitao T, Haydon T. Comparison of anesthetic and cardiorespiratory effects of tiletaminezolazepam-butorphanol and tiletamine-zolazepam-butorphanolmedetomidine in dogs. Vet Ther 2007; 8: 113-126.
  10. Pypendop BH, Verstegen JP. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998; 27: 612-622. https://doi.org/10.1111/j.1532-950X.1998.tb00539.x
  11. Savvas I, Plevraki K, Raptopoulos D, Koutinas AF. Blood gas and acid-base status during tiletamine/zolazepam anaesthesia in dogs. Vet Anaesth Analg 2005; 32: 94-100. https://doi.org/10.1111/j.1467-2995.2004.00177.x
  12. Vettorato E, Zonca A, Isola M, Villa R, Gallo M, Ravasio G, Beccaglia M, Montesissa C, Cagnardi P. Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs. Vet J 2010; 183: 310-315. https://doi.org/10.1016/j.tvjl.2008.11.002
  13. Walzer C, Huber C. Partial antagonism of tiletamine-zolazepam anesthesia in cheetah. J Wildl Dis 2002; 38: 168-472.

Cited by

  1. Evaluation of Autoligation Technique for Castration in Small Breed Dogs vol.37, pp.2, 2015, https://doi.org/10.17555/jvc.2020.04.37.2.75