Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Comparison of Linear-Quadratic Model, Incomplete-Repair Model and Marchese Model in Fractionated Carbon Beam Irradiation

탄소 빔 분할조사 시 Linear-Quadratic모델, Incomplete-Repair모델, Marchese 모델 결과 비교

  • Choi, Eunae (Department of Bio-convergence Engineering, Korea university)
  • 최은애 (고려대학교 바이오융합공학과)
  • Received : 2015.10.01
  • Accepted : 2015.10.25
  • Published : 2015.10.30
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Abstract

We obtained Surviving Fraction (SF) after irradiation carbon beam to compare the applicability of the Linear-Quadratic model, Incomplete Repair model, Marchese model. Mathematica software(ver 9.0) used to calcurate parameters and compared result. LQ model could not explain the entire response of fractionated carbon beam irradiation. It becomes necessary to construct models that extend the LQ model of conventional radiotherapy for the carbon beam therapy. By combining both Potentially Lethal Damage Repair (PLDR) and Sublethal Damage Repair (SLDR) a new LQ model can develop that aptly modeled the cellular response to fractionated irradiation.

본 연구는 탄소 빔의 분할조사 후 세포생존율 (Surviving Fraction, SF) 값에 따른 Linear-Quadratic model, Incomplete Repair model, Marchese model의 결과값을 비교하기 위해 진행하였다. 탄소 빔을 4fraction까지 조사한 후 얻은 세포생존율 값을 바탕으로 mathematica 프로그램 (ver 9.0)을 이용하여 각각의 모델로 결과값을 얻어 비교해 보았다. 그 결과 즉시 NB1RGB를 시딩한 값은 repair가 감안되지 않은 LQ 모델이 적합하였지만 fraction 시행한 후의 결과값은 오차를 보였다. 따라서 Potentially Lethal Damage Repair (PLDR)과 Sublethal Damage Repair (SLDR)의 발생을 각각 감안한 repair 모델을 이용하여 적합한지 판단하였다. 이를 바탕으로 탄소 빔의 분할 조사 시 LQ 모델에 각각의 repair의 양을 감안한 새로운 회복 관련 모델의 적용 가능성을 보고자 하였다.

Keywords

References

  1. Mami wada et al, "Mpdeling the biological response of normal human cells, including beam irradiation" JRR, pp.1-10, 2013.
  2. Hiromitsu IWATA et al, "Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated rediation doses to single doses" JRR, pp 367-373, 2013.
  3. B. K. Lind et al, "Repairable-Conditionally Repairable Damage Model Based on dual poisson processed" Radiation research, pp 366-375, 2003.
  4. Howard D. Thames, "An 'incomplete-repair' model for survival after fractionated and continuous irradiations" INT.j. RADIAT. BIOL, Vol. 47, pp 319-339, 1985. https://doi.org/10.1080/09553008514550461
  5. Akifumi Miyakawa, "Applicability of the linear-quadratic model to single and fractionated radiotherapy schedules: an experimental study" Journal of Radiation, pp. 1-4, 2013.
  6. Cornelius A. Tobias, "The Repair-Misrepair model in radiobiology: Comparison to other models" Radiation Research, pp. 77-95, 1985.
  7. Stanley B. Curtis, "Lethal and potentially lethal lesions induced by radiation - A unified repair model", Radiation research, pp. 252-270, 1986.
  8. M. Wedenberg, "Analytical Description of the LET dependence of cell survival using the repairable-conditionallly repairable damage model", Radiation Research, pp. 517-525, 2010.
  9. Alejandro carabe-fernandez et al, "The incorporation of the concept of minimum RBE into the linear-quadratic model and potential for improved daiobiological analysis of high-LET tratments" int. j. Radiat. Biol, Vol. 83, No. 1, pp. 27-39, 2006. https://doi.org/10.1080/09553000601087176
  10. Hiromitsu Iwata ea al, "Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses: an in vitro study" Int J. Radiation Oncology, Vol. 75, No. 2, pp. 482-488, 2009. https://doi.org/10.1016/j.ijrobp.2008.12.093
  11. Anatoly dritschilo et al, "Repair of radiation damage in plateau-phase mammalian dells: relationship between sub-lethal and potentially lethal damage states" Int. J. Radiat. biol, Vol. 30, No. 6, pp. 565-569, 1976. https://doi.org/10.1080/09553007614551421

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