The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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The Effects of Lentinula edodes and Aquilariae agallocha Extracts Combination on the Repair of UVA-Damaged DNA and DNCB-Induced Allergic Dermatitis

자외선A로 손상된 DNA의 회복과 DNCB에 의한 알러지성 접촉피부염에 대한 표고버섯과 침향 추출 혼합물의 효과

  • Kim, Min Seob (Research Institute for Basic Science and Division of Biological Science, Wonkwang University) ;
  • Hwang, Hyun Ik (Research Institute for Basic Science and Division of Biological Science, Wonkwang University) ;
  • Lee, Yu Ri (Research Institute for Basic Science and Division of Biological Science, Wonkwang University) ;
  • Kim, Ho Won (Wonkwang Biosysyem Co., Ltd., Wonkwang University) ;
  • Park, Jong Kun (Research Institute for Basic Science and Division of Biological Science, Wonkwang University)
  • 김민섭 (원광대학교 생명과학부 기초자연과학연구소) ;
  • 황현익 (원광대학교 생명과학부 기초자연과학연구소) ;
  • 이유리 (원광대학교 생명과학부 기초자연과학연구소) ;
  • 김호원 (원광바이오 시스템) ;
  • 박종군 (원광대학교 생명과학부 기초자연과학연구소)
  • Received : 2015.07.07
  • Accepted : 2015.09.11
  • Published : 2015.10.31
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Abstract

The effects of extracts from Lentinula edodes (L. edodes) and Aquilariae agallocha (A. agallocha) on the DNA damage response in ultraviolet A (UVA)-exposed HaCaT cells and on the allergic contact dermatitis caused by 2,4-dinitro-chlorobezene (DNCB) were investigated. When UVA-exposed cells were incubated for 24 hours in medium containing L. edodes or A. agallocha extract, the level of 8-OHdG and CPD decreased in a concentration-dependent manner. The combined treatment with both extracts potentiated the decrease in UVA-induced 8-OHdG and CPD levels as compared with those following treatment with a single extract. In addition, the two extracts showed preventive effects against the UVA-induced reduction in collagen levels. Furthermore, the blood levels of IgE, IL-6, and histamine decreased more significantly upon combined treatment with L. edodes and A. agallocha extracts as compared with those following treatment with single extracts in DNCB-induced allergic contact dermatitis in the ICR mouse. The results of the present study suggest that the components with in the extracts of L. edodes and A. agallocha can help to prevent of UVA-induced genomic instability via a decrease in DNA damage, and to decrease the DNCB-induced allergic dermatitis via modulation of relevant proteins including IgE and IL-6. Further study is needed to clarify the purified components related to the preventative effects of the two extracts against UVA- or DNCB-induced genomic damage.

Keywords

References

  1. Bae MJ, Ye EJ. 2007. Effect of mycelia extracts from Lentinus edodes mushroom-cultured Lonicera japonica Thunberg on anticancer and antiallergy activities. J Kor Soc Food Sci Nutr 36:424-430 https://doi.org/10.3746/jkfn.2007.36.4.424
  2. Behn H, Albert A, Marx F, Noga G, Ulbrich A. 2010. Ultraviolet-B and photosynthetically active radiation interactively affect yield and pattern of monoterpenes in leaves of peppermint (Mentha piperita L.). J Agric Food Chem 58:7361-7367 https://doi.org/10.1021/jf9046072
  3. Bhandari P, Pant P, Rastogi RP. 1982. Aquillochin, a coumarinolignan from Aquilaria agallocha. Phytochemistry 21:2147-2149 https://doi.org/10.1016/0031-9422(82)83075-6
  4. Byun SH, Lee BW, Kim SC. 2005. Effect of Samyoyongantang on contact hypersensitivity induced by repeat elicitation of DNCB. Kor J Oriental Medic Prescrip 13:59-69
  5. Chen CH, Kuo TC, Yang MH, Chien TY, Chu MJ, Huang LC, Chen CY, Lo HF, Jeng ST, Chen LF. 2014. Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha. BMC Genomics 15:578 https://doi.org/10.1186/1471-2164-15-578
  6. Duale N, Olsen AK, Christensen T, Butt ST, Brunborg G. 2010. Octyl methoxycinnamate modulates gene expression and prevents cyclobutane pyrimidine dimer formation but not oxidative DNA damage in UV-exposed human cell lines. Toxicol Sci 114:272-284 https://doi.org/10.1093/toxsci/kfq005
  7. Filip A, Daicoviciu D, Clichici S, Mocan T, Muresan A, Postescu ID. 2011. Photoprotective effects of two natural products on ultraviolet B-induced oxidative stress and apoptosis in SKH-1 mouse skin. J Med Food 14:761-766 https://doi.org/10.1089/jmf.2010.0142
  8. Guo Z, Zhou B, Liu W, Xu Y, Wu D, Yin Z, Permatasari F, Luo D. 2013. MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells. J Dermatol Sci 69:68-76 https://doi.org/10.1016/j.jdermsci.2012.10.014
  9. Hong JS, Kim TH. 1989. Contents of free amino acids and total amino acids in Agaricus bisporus, Pleurotus ostreatus and Lentinus edodes. Kor J Food Sci Technol 21:58-62
  10. Ishohara M, Tsumeya T, Uneyama K. 1993. Sesquiterpene constituents in agarwood. Phytochemistry 33:1147 https://doi.org/10.1016/0031-9422(93)85039-T
  11. Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW. 2012. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes. Environ Toxicol Pharmacol 34:926-934 https://doi.org/10.1016/j.etap.2012.08.003
  12. Kim CH, Kim KJ. 2005. The effects of Yanghyulsamultanggamibang to allergic contact dermatitis. J Kor Oriental Medic Ophthal & Otolaryngol & Dermatol 18:13-26
  13. Kim CJ, Kim YB, Ku YH, Nam HJ. 2005. The effects of Sophorae radix and Coptidis rhizoma iotophoresis in allergic contact dermatitis. J Kor Oriental Medic Ophthal & Otolaryngol & Dermatol 18:1999-220
  14. Kim MJ, Chu WM, Park EJ. 2012. Antioxidant and antigenotoxic effects of Shiitake mushrooms affected by different drying methods. J Kor Soc Food Sci Nutr 41:1041-1048 https://doi.org/10.3746/jkfn.2012.41.8.1041
  15. Kim SC, Lee JR, Choi KI, Park SJ, Kwon YK, Byun SH. 2006. Effect of lonicerae flos-skin on contact hypersensitivity induced by repeat elicitation of DNCB. Kor J Herbol 21:9-15
  16. Kim YC, Jeong SJ, Kim HM. 1997. Antiallergic effect of Aquilariae lignum. Yakhak Hoeji 41:255-259
  17. Lario LD, RamirezParra E, Gutierrez C, Casati P, Spampinato CP. 2011. Regulation of plant MSH2 and MSH6 genes in the UV-B-induced DNA damage response. J Exp Bot 62:2925-2937 https://doi.org/10.1093/jxb/err001
  18. Lee JK, Shin JS, Kim JH, Um JH, Son KH, Gil JH, Kim J, Yoon BI, Kim HS, Park GL. 2005. Evaluation of immunosafety for skin sensitization induced by chemicals. Toxicological Res 4:81-90
  19. Lim JH, Park YM, Kim JS, Jeong HY, Seo EW. 2011. Effect of Cnidium officinale extract on recovery capability of allergic contact dermatitis in rat. Kor J Plant Re 24:430-437 https://doi.org/10.7732/kjpr.2011.24.4.430
  20. Masuma R, Kashima S, Kurasaki M, Okuno T. 2013. Effects of UV wavelength on cell damages caused by UV irradiation in PC12 cells. J Photochem Photobiol 125:202-208 https://doi.org/10.1016/j.jphotobiol.2013.06.003
  21. Matsuda M, Hoshino T, Yamashita Y, Tanaka K, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T. 2010. Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem 285:5848-5858 https://doi.org/10.1074/jbc.M109.063453
  22. Mizuno M, Nishitani Y. 2013. Immunomodulating compounds in Basidiomycetes. J Clin Biochem Nutr 52:202-207 https://doi.org/10.3164/jcbn.13-3
  23. Okugawa H, Ueda R, Matsumoto K, Kawan-ishi K, Kato A. 1993. Effects of agarwood ex-tracts on the central nervous system in mice. Planta Med 59:32-36 https://doi.org/10.1055/s-2006-959599
  24. Park SY. 2009. Verification of effects for anticancer and antioxidation of extracts from Lentinus edodes mycelia cultivated through Rubus coreanus Miquel. Master Thesis, Daegu Haany Univ. Korea
  25. Pontin MA, Piccoli PN, Francisco R, Bottini R, Martinez Zapater JM, Lijavetzky D. 2010. Transcriptome changes in grapevine (Vitis vinifera L.) cv. Malbec leaves induced by ultraviolet-B radiation. BMC Plant Biol 10:224 https://doi.org/10.1186/1471-2229-10-224
  26. Rastogi RP, Richa KA, Tyagi MB, Sinha RP. 2010. Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair. J Nucleic Acids 10:4061
  27. Roy S, Deep G, Agarwal C, Agarwal R. 2012. Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45${\alpha}$-dependent manner. Carcinogenesis 33:629-636 https://doi.org/10.1093/carcin/bgr299
  28. Shin GS. 2000. The effects of Rhemanniae radix extract on allergic contact dermatitis induced by DNCB in mice. Dongguk University 8:257-279
  29. Yeon JH. 2009. The effects on the antioxidant activity and the toxicity of SK-MEL-5 cell of Aquilaria agallocha extract. Master Thesis, Kyonggi Univ. Korea
  30. Yin Y, Li W, Son YO, Sun L, Lu J, Kim D, Wang X, Yao H, Wang L, Pratheeshkumar P, Hitron AJ, Luo J, Gao N, Shi X, Zhang Z. 2013. Quercitrin protects skin from UVBinduced oxidative damage. Toxicol Appl Pharmacol 269:89-99 https://doi.org/10.1016/j.taap.2013.03.015

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