Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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The oral dose toxicity test and skin irritation test of eco-friendly plasticizer using crude glycerol derived

폐글리세롤을 이용한 친환경 가소제의 경구투여독성 및 피부자극성 시험

  • Kang, Soo-Jung (Department of Polymer Science and Engineering, Sungkyunkwan University) ;
  • Kim, Heeyoung (Department of Polymer Science and Engineering, Sungkyunkwan University) ;
  • Park, Sangwon (Department of Polymer Science and Engineering, Sungkyunkwan University) ;
  • Sim, Eunyoung (Department of Polymer Science and Engineering, Sungkyunkwan University) ;
  • Kim, Jinhwan (Department of Polymer Science and Engineering, Sungkyunkwan University)
  • 강수정 (성균관대학교 고분자시스템공학과) ;
  • 김희영 (성균관대학교 고분자시스템공학과) ;
  • 박상원 (성균관대학교 고분자시스템공학과) ;
  • 심은영 (성균관대학교 고분자시스템공학과) ;
  • 김진환 (성균관대학교 고분자시스템공학과)
  • Received : 2015.08.30
  • Accepted : 2015.09.20
  • Published : 2015.09.30
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Abstract

Objectives: The major objective of this study is the oral dose toxicity test and skin irritation test of eco-friendly plasticizer using crude glycerol derived from the biodiesel process. Methods: Glyceroldiacetate laurate(GDL) was synthesized from glycerol monolaurat(GML) and acetic acid. The synthesis of the GDL plasticizer was measured with nuclear magnetic resonance spectroscop(NMR) and FT-IR(Fourier Transform Infrared Spectrometer). To provide information on the safety of GDL, we carried out an oral dose toxicity test for GDL in Sprague-Dawley rats. Also, we carried out a skin irritation test for GDL in New Zealand White rabbits. Results: The oral dose toxicity test in Sprague-Dawley rats showed that GDL is a non-toxic material. The result of the skin irritation test on New Zealand White rabbits showed that GDL is non-irritating. Conclusions: From the results of oral dose toxicity test and skin irritation test, we concluded that the developed plasticizer showed excellent eco-friendly property. Based on our results, we confirmed the development of an eco-friendly non-phthalate plasticizer. Applicability for PVC toys and food and drug packaging materials was found.

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