Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

  • Okuturlar, Yildiz (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Gunaldi, Meral (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Tiken, Elif Eda (Radiation Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Oztosun, Bugra (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Inan, Yesim Ozdem (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Ercan, Tarik (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Tuna, Savas (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Kaya, Ali Osman (Medical Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Harmankaya, Ozlem (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Kumbasar, Abdulbaki (Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital)
  • Published : 2015.04.03
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Abstract

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

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References

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