Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus

  • Lee, Choong Hyun (Department of Pharmacy, College of Pharmacy, Dankook University) ;
  • Yi, Min-Hee (Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine) ;
  • Chae, Dong Jin (Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine) ;
  • Zhang, Enji (Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine) ;
  • Oh, Sang-Ha (Department of Plastic Surgery, Chungnam National University Hospital) ;
  • Kim, Dong Woon (Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine)
  • Received : 2014.12.22
  • Accepted : 2015.02.07
  • Published : 2015.05.01
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Abstract

Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor ${\gamma}$ agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the effects of 30 mg/kg PGZ on excitotoxic neuronal damage and glial activation in the mouse hippocampus following intracerebroventricular injection of kainic acid (KA). PGZ treatment significantly reduced seizure-like behavior. PGZ had the neuroprotective effect against KA-induced neuronal damage and attenuated the activations of astrocytes and microglia in the hippocampal CA3 region. In addition, MPO and $NF{\kappa}B$ immunoreactivities in the glial cells were also decreased in the PGZ-treated group. These results indicate that PGZ had anticonvulsant and neuroprotective effects against KA-induced excitotocix injury, and that neuroprotective effect of PGZ might be due to the attenuation of KA-induced activation in astrocytes and microglia as well as KA-induced increases in MPO and $NF{\kappa}B$.

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References

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