The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effect of Picrorrhizae Rhizoma Aqueous Extracts on Paw Chronic Inflammation In Mice

  • Leem, Ji-Young (Department of Herbology, College of Oriental Medicine, Daegu Hanny University) ;
  • Ku, Sae-Kwang (Department of Anatomy and Histoloty, College of Oriental Medicine, Daegu Hanny University) ;
  • Seo, Bu-Il (Department of Herbology, College of Oriental Medicine, Daegu Hanny University) ;
  • Jeon, Mi-Hye (Department of Herbology, College of Oriental Medicine, Daegu Hanny University) ;
  • Park, Ji-Ha (Department of Herbology, College of Oriental Medicine, Daegu Hanny University)
  • Received : 2015.05.25
  • Accepted : 2015.06.19
  • Published : 2015.06.30
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Abstract

Objectives: The purpose of this study was to examine the efficacy of Picrorrhizae Rhizoma (PR) aqueous extracts on the formalin-induced paw chronic inflammation in mice. Methods: PR extracts (500, 250 and 125mg/kg) or distilled water (DW) were orally administered once a day for 10 days to formalin-injected chronic inflammatory mice. The paw thicknesses and volumes were measured daily and the paw wet-weight and histological profiles were conducted at termination with paw tumor necrosis factor (TNF)-${\alpha}$ contents measurement. The anti-inflammatory effects of PR extracts were compared with dexamethasone. Results: In DW treated control group, the paw thickness, paw wet-weights and paw TNF-${\alpha}$ contents were markedly increased. Severe chronic inflammation signs such as severe fibrosis, the formation of necrotic debris, and infiltration of inflammatory cells were detected in histopathological observations. However, these formalin-induced changes were dramatically decreased by treatment of dexamethasone and all three different dosages of PR extracts. The anti-inflammatory effects of PR at highest dose were slighter than that of dexamethasone, but it did not show any harmful effects on the body weight contrary to dexamethasone. Conclusion: These results suggest that PR extracts have safe and favorable effects on formalin-induced chronic inflammation.

Keywords

References

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