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Toxicity study to Ensure the Safety of Corydalis turtschaninovii BESS

현호색의 안전한 활용을 위한 독성시험연구

  • 이승범 (세명대학교 외식경영학과) ;
  • 하현용 (세명대학교 한방바이오융합과학부)
  • Received : 2015.04.23
  • Accepted : 2015.06.08
  • Published : 2015.06.28

Abstract

This study was carried out to evaluate the acute oral toxicity of Corydalis turtschaninovii BESS. in Sprague-Dawley(SD) rats. Male and female rats were administered orally with Corydalis turtschaninovii BESS water extract. We measured the number of death by clinical signs and gross findings for 7 days. After 7 days, we measured the whole body and individual organs' weight. We also analyzed hematological changes. The result, no dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. The results indicated that there were no significant changes of gross body and individual organs weight in SD rats. These results suggest that water soluble extract of Corydalis turtschaninovii BESS. has not acute oral toxicity in SD rats.

본 연구에서는 현호색에 대한 기본적인 독성을 조사하고, 식품 소재로서의 현호색에 대한 활용가능성을 제시하고자 하였다. 현호색의 열수 추출물을 제조하여 농도별로 마우스에 투여한 뒤 사망률과 임상증상을 관찰하였으며, 장기를 적출하여 각각의 절대중량과 상대중량을 측정하였다. 또한 혈액학적 검사와 혈액생화학적 검사 및 조직병리학적 검사를 통하여 현호색의 안전성에 대하여 검토하였다. 그 결과 사망한 개체는 없었으며, 장기중량에 있어서도 유의적인 변화를 보이지는 않았으나, 혈액생화학적으로 일부 유의성 있는 변화를 나타내었다. 이로써 현호색이 식품의 부재료 또는 첨가제로서의 활용이 가능한 소재로 판단되며, 다양한 활용방법 및 추가적인 안전성 관련 연구가 필요할 것으로 사료된다.

Keywords

References

  1. S. C. Jeong, J. H. Park, and J. H. Kim, "The Development Trend of Skin Beauty Food with Skin Protection Effects from Natural Source," Korean Journal of Aesthet. Cosmetol, Vol.11, No.2, pp.71-80, 2013.
  2. T. W. Oh, H. S. Bae, C. H. Yoon, and Y. K. Park, "Thirteen-week repeated-dose oral toxicity study of the Modified Wenpitang-Hab-Wulingsan (WHW(R)) in Sprague-Dawley rats," Korean Journal of Herbology, Vol.25, No.3, pp.43-51, 2010.
  3. T. H. Kim, S. Jang, A. R. Lee, A. Y. Lee, G. Choi, and H. K. Kim, "The Analysis of Residual Pesticides and Sulfur Dioxide in Commercial Medicinal Plants," Korean Journal of Herbology, Vol.27, No.6, pp.43-48, 2012.
  4. H. M. Park, H. T. Shin, and S. D. Lee, Herbal Toxicological Effects on Rats' Fetus-Focusing on Ojeoksan-," Korean Journal of Oriental Preventive Medical Society, Vol.12, No.2, pp.27-35, 2008.
  5. S. Y. Hwang, W. Kwon, H. Y. Chai, Y. M. Cho, N. J. Lee, J. M. Ryu, J. S. Sin, T. M. Kim, J. H. Cho, E, J. Kim, J. H. Park, J. K. Kang, and Y. B. Kim, "Four-week repeated-dose toxicity study on Mori radicis Cortex," The Korean journal of laboratory animal science, Vol.20, No.3, pp.283-290, 2004.
  6. M. C. Lim and D. H. Kim, "The Experimental Studies on Antithrombotic Effect of Hyunhosaiksan," Korean Journal of Oriental Physiology & Pathology, Vol.17, No.4, pp.930-938, 2003.
  7. H. S. Ahn, Y. B. Park, and S. K. Kang, "Effects of the Corydalis Tuber Aqua - acupuncture on the Pain and Convulsion in Mice and Gastric Ulcer in Rats," Journal of Korean acupuncture & moxibustion medicine society, Vol.11, No.1, pp.99-111, 1994.
  8. H. J. Lee, D. C. Kim, and S. H. Baek, "Effect of Corydalis Tuber on the inhibition of proliferation of human uterine Leiomyoma cell and apoptotic gene expression," The Journal of Oriental Gynecology, Vol.19, No.2, pp.214-225, 2006.
  9. I. H. Sung and W. S. Chae, "The Effects of Aqua-acupunctures of Hyunhoshag and Dangghuimi on Thrombosis Induced by Endotoxin in Rats," Journal of Korean acupuncture & moxibustion medicine society, Vol.11, No.1, pp.391-404, 1994.
  10. H. Y. Ha, boncohakyimyungsajun. 1st ed, Seoul:passanpass, Vol.1, p.511, 2007.
  11. X. M. Hu, W. K. Zhang, H. J. Zhang, H. M. Dong, K. W. Xie, and B. X. Wu et al. Zhonghwabencao Jingxuanben, 2nd ed, Shanghai:kejichubanshe, Vol.1, pp.686-694, 1998.
  12. I. O. Surh, C. S. Jeong, and K. H. Jung, "Mechanism and Effect of Corydalis ternata on the CCI_4-Induced Hepatotoxicity," Journal of Food Hygiene and Safety, Vol.15, No.3, pp.226-234, 2000.
  13. K. S. Kim, "Present Status and Perspectives of Medicinal Plant Resources in Korea," Research of national Resources," Vol.2, pp.25-41, 1999.
  14. K. T. Kweon, "A Reasearch on Management System of Herbal Medicine in Common Use for Food and Medicine," Korean Journal of Herbology, Vol.27, No.2, pp.25-29, 2012.
  15. B. I. Seo and S. M. Kim, "A Philological Study on poisoning of Corydalis Tuber," The journal of Jehan Oriental Medical Academy, Vol.6, No.1, pp.87-99, 2008.
  16. B. U. Oh, "A taxonomic review of Korean Corydalis (Fumariaceae)," Korean Journal of Plant. Tax, Vol.29, No.3, pp.201-230, 1999. https://doi.org/10.11110/kjpt.1999.29.3.201
  17. B. M. Min, "Several Growth Properties of Pes-gallinaceua (Corydalis, Fumariaceae) Group," Journal of Ecology and Environment, Vol.26, No.4, pp.181-188, 2003.
  18. Y. K. Park, Y. C. Park, and S. Y. Kang, "Thirteen-week repeated-dose oral toxicity study of KOB03, a polyherbal medicine for allergic rhinitis, in rats," Korean Journal of Herbology, Vol.28, No.1, pp.15-21, 2013.