Journal of Korean Neurosurgical Society

  • 제57권3호
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  • Pages.152-158
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  • 2015
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Fully Implantable Deep Brain Stimulation System with Wireless Power Transmission for Long-term Use in Rodent Models of Parkinson's Disease

  • Heo, Man Seung (Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University) ;
  • Moon, Hyun Seok (Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University) ;
  • Kim, Hee Chan (Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University) ;
  • Park, Hyung Woo (Department of Neurosurgery, Seoul National University Hospital) ;
  • Lim, Young Hoon (Department of Neurosurgery, Seoul National University Hospital) ;
  • Paek, Sun Ha (Department of Neurosurgery, Seoul National University Hospital)
  • 투고 : 2014.09.17
  • 심사 : 2014.10.25
  • 발행 : 2015.03.28
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초록

Objective : The purpose of this study to develop new deep-brain stimulation system for long-term use in animals, in order to develop a variety of neural prostheses. Methods : Our system has two distinguished features, which are the fully implanted system having wearable wireless power transfer and ability to change the parameter of stimulus parameter. It is useful for obtaining a variety of data from a long-term experiment. Results : To validate our system, we performed pre-clinical test in Parkinson's disease-rat models for 4 weeks. Through the in vivo test, we observed the possibility of not only long-term implantation and stability, but also free movement of animals. We confirmed that the electrical stimulation neither caused any side effect nor damaged the electrodes. Conclusion : We proved possibility of our system to conduct the long-term pre-clinical test in variety of parameter, which is available for development of neural prostheses.

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참고문헌

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피인용 문헌

  1. The Current Status of Deep Brain Stimulation for the Treatment of Parkinson Disease in the Republic of Korea vol.8, pp.3, 2015, https://doi.org/10.14802/jmd.15043
  2. A Remote and Wireless Deep Brain Stimulation Programming System vol.19, pp.4, 2016, https://doi.org/10.1111/ner.12448
  3. Wireless Power Transfer for Implanted Medical Application: A Review vol.13, pp.11, 2015, https://doi.org/10.3390/en13112837