Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.

  • Jia, Yan-Lai (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China) ;
  • Guan, Fei-Fei (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China) ;
  • Ma, Jie (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China) ;
  • Wang, Chang-Yun (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China) ;
  • Shao, Chang-Lun (Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China)
  • Received : 2015.04.30
  • Accepted : 2015.06.05
  • Published : 2015.12.31
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Abstract

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin ($IC_{50}=418.0{\mu}M$), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an $IC_{50}$ value of $27.7{\mu}M$. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.

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References

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