Biomaterials and Biomechanics in Bioengineering

  • 제2권1호
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  • Pages.1-13
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  • 2015
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  • 2465-9835(pISSN)
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  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Recent advances in utilization of photochemical internalization (PCI) for efficient nano carrier mediated drug delivery

  • Park, Wooram (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea) ;
  • Park, Sin-Jung (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea) ;
  • Lee, Jun (Gyeonggi-Academy of Foreign Languages) ;
  • Na, Kun (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea)
  • 투고 : 2015.01.23
  • 심사 : 2015.02.02
  • 발행 : 2015.03.25
⟨ 이전 논문 다음 논문 ⟩

초록

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

참고문헌

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