Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지
DOI QR코드

DOI QR Code

Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion

  • Choi, Won-Young (Department of Materials Science and Engineering, Seoul National University) ;
  • Kim, Hyoun-Ee (Department of Materials Science and Engineering, Seoul National University) ;
  • Moon, Young-Wook (School of Biomedical Engineering, Korea University) ;
  • Shin, Kwan-Ha (School of Biomedical Engineering, Korea University) ;
  • Koh, Young-Hag (School of Biomedical Engineering, Korea University)
  • Received : 2014.11.10
  • Accepted : 2015.06.09
  • Published : 2015.09.30
⟨ Previous Next ⟩

Abstract

Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity. Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold. Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare

References

  1. Jones JR, Hench LL. Regeneration of trabecular bone using porous ceramics. Curr Opin Solid St M. 2003;7:301-7. https://doi.org/10.1016/j.cossms.2003.09.012
  2. Hing KA. Bioceramic bone graft substitutes: influence of porosity and chemistry. Int J Appl Ceram Tech. 2005;2:184-99. https://doi.org/10.1111/j.1744-7402.2005.02020.x
  3. Dorozhkin SV. Calcium orthophosphates as bioceramics: state of the art. J Funct Biomater. 2010;1:22-107. https://doi.org/10.3390/jfb1010022
  4. Dorozhkin SV. Bioceramics of calcium orthophosphates. Biomaterials. 2010;31:1465-85. https://doi.org/10.1016/j.biomaterials.2009.11.050
  5. Dorozhkin SV. Biphasic, triphasic and multiphasic calcium orthophosphates. Acta Biomater. 2012;8:963-77. https://doi.org/10.1016/j.actbio.2011.09.003
  6. Studart AR, Gonzenbach UT, Tervoort E, Gauckler LJ. Processing routes to macroporous ceramics: a review. J Am Ceram Soc. 2006;89:1771-89. https://doi.org/10.1111/j.1551-2916.2006.01044.x
  7. Jo IH, Shin KH, Soon YM, Koh YH, Lee JH, Kim HE. Highly porous hydroxyapatite scaffolds with elongated pores using stretched polymeric sponges as novel template. Mater Lett. 2009;63:1702-4. https://doi.org/10.1016/j.matlet.2009.05.017
  8. He X, Zhang YZ, Mansell JP, Su B. Zirconia toughened alumina ceramic foams for potential bone graft applications: fabrication, bioactivation, and cellular responses. J Mater Sci Mater Med. 2008;19:2743-9. https://doi.org/10.1007/s10856-008-3401-x
  9. Akartuna I, Studart AR, Tervoort E, Gauckler LJ. Macroporous ceramics from particle-stabilized emulsions. Adv Mater. 2008;20:4714-8. https://doi.org/10.1002/adma.200801888
  10. Barg S, Soltmann C, Andrade M, Koch D, Grathwohl G. Cellular ceramics by direct foaming of emulsified ceramic powder suspensions. J Am Ceram Soc. 2008;91:2823-9. https://doi.org/10.1111/j.1551-2916.2008.02553.x
  11. Barg S, Moraes EG, Koch D, Grathwohl G. New cellular ceramics from high alkane phase emulsified suspensions (HAPES). J Eur Ceram Soc. 2009;29:2439-46. https://doi.org/10.1016/j.jeurceramsoc.2009.02.003
  12. Montufar EB, Traykova T, Gil C, Harr I, Almirall A, Aguirre A, et al. Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration. Acta Biomater. 2010;6:876-85. https://doi.org/10.1016/j.actbio.2009.10.018
  13. Ahn MK, Shin KH, Moon YW, Koh YH, Choi WY, Kim HE. Highly porous biphasic calcium phosphate (BCP) ceramics with large interconnected pores by freezing vigorously foamed BCP suspensions under reduced pressure. J Am Ceram Soc. 2011;94:4154-6. https://doi.org/10.1111/j.1551-2916.2011.04904.x
  14. Ahn MK, Moon YW, Koh YH, Kim HE. Use of glycerol as a cryoprotectant in vacuum-assisted foaming of ceramic suspension (VFC) technique for improving compressive strength of porous biphasic calcium phosphate (BCP) ceramics. J Am Ceram Soc. 2012;95:3360-2. https://doi.org/10.1111/j.1551-2916.2012.05443.x
  15. Deville S, Saiz E, Nalla RK, Tomsia AP. Freezing as a path to build complex composites. Science. 2006;311:515-8. https://doi.org/10.1126/science.1120937
  16. Tang YF, Miao Q, Qiu S, Zhao K, Hu L. Novel freeze-casting fabrication of aligned lamellar porous alumina with a centrosymmetric structure. J Eur Ceram Soc. 2014;34:4077-82. https://doi.org/10.1016/j.jeurceramsoc.2014.05.040
  17. Ghazanfari SMH, Zamanian A. Effect of nanosilica addition on the physicomechanical properties, pore morphology, and phase transformation of freeze cast hydroxyapatite scaffolds. J Mater Sci. 2014;49:5429-504.
  18. Loh QL, Choong C. Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size. Tissue Eng Part B Rev. 2013;19:485-502. https://doi.org/10.1089/ten.teb.2012.0437
  19. Gibson LJ. Biomechanics of cellular solids. J Biomech. 2005;38:377-99. https://doi.org/10.1016/j.jbiomech.2004.09.027
  20. Deville S, Saiz E, Tomsia AP. Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. Biomaterials. 2006;27:5480-9. https://doi.org/10.1016/j.biomaterials.2006.06.028
  21. Deville S, Saiz E, Tomsia AP. Ice-templated porous alumina structures. Acta Mater. 2007;55:1965-74. https://doi.org/10.1016/j.actamat.2006.11.003
  22. Liu G, Zhang D, Meggs C, Button TW. Porous $Al_2O_3-ZrO_2$ composites fabricated by an ice template method. Scripta Mater. 2010;62:466-8. https://doi.org/10.1016/j.scriptamat.2009.12.018
  23. Fu Q, Rahaman MN, Dogan F, Bal BS. Freeze casting of porous hydroxyapatite scaffolds-I. processing and general microstructure. J Biomed Mater Res B. 2008;86B:125-35. https://doi.org/10.1002/jbm.b.30997
  24. Pekor CM, Kisa P, Nettleship I. Effect of polyethylene glycol on the microstructure of freeze-cast alumina. J Am Ceram Soc. 2008;91:3185-90. https://doi.org/10.1111/j.1551-2916.2008.02616.x
  25. Munch E, Saiz E, Tomsia AP, Deville S. Architectural control of freeze-cast ceramics through additives and templating. J Am Ceram Soc. 2009;92:1534-9. https://doi.org/10.1111/j.1551-2916.2009.03087.x
  26. Zuo KH, Zeng YP, Jiang DL. Effect of cooling rate and polyvinyl alcohol on the morphology of porous hydroxyapatite ceramics. Mater Design. 2010;31:3090-4. https://doi.org/10.1016/j.matdes.2009.12.044
  27. Waschkies T, Oberacker R, Hoffmann MJ. Control of lamellae spacing during freeze casting of ceramics using double-side cooling as a novel processing route source. J Am Ceram Soc. 2009;92:S79-84. https://doi.org/10.1111/j.1551-2916.2008.02673.x
  28. Zhang YM, Hu LY, Han JC. Preparation of a dense/porous bi-layered ceramic by applying an electric field during freeze casting. J Am Ceram Soc. 2009;92:1874-6. https://doi.org/10.1111/j.1551-2916.2009.03110.x
  29. Tang YF, Zhao K, Wei JQ, Qin YS. Fabrication of aligned lamellar porous alumina using directional solidification of aqueous slurries with an applied electrostatic field. J Eur Ceram Soc. 2010;30:1963-5. https://doi.org/10.1016/j.jeurceramsoc.2010.03.012
  30. Yoon BH, Choi WY, Kim HE, Kim JH, Koh YH. Aligned porous alumina ceramics with high compressive strengths for bone tissue engineering. Scripta Mater. 2008;58:537-40. https://doi.org/10.1016/j.scriptamat.2007.11.006
  31. Soon YM, Shin KH, Koh YH, Lee JH, Kim HE. Compressive strength and processing of camphene-based freeze cast calcium phosphate scaffolds with aligned pores. Mater Lett. 2009;63:1548-50. https://doi.org/10.1016/j.matlet.2009.04.013
  32. Soon YM, Shin KW, Koh YH, Choi WY, Kim HE. Assembling uinidirectionally frozen alumina/camphene bodies for aligned porous alumina ceramics with larger dimensions. J Eur Ceram Soc. 2011;31:415-9. https://doi.org/10.1016/j.jeurceramsoc.2010.09.019
  33. Halloran J. Materials science. Making better ceramic composites with ice. Science. 2006;311:479-80. https://doi.org/10.1126/science.1123220
  34. Moon YW, Shin KH, Koh YH, Choi WY, Kim HE. Production of highly aligned porous alumina ceramics by extruding frozen alumina/camphene body. J Eur Ceram Soc. 2011;31:1945-50. https://doi.org/10.1016/j.jeurceramsoc.2011.04.033
  35. Moon YW, Shin KH, Koh YH, Choi WY, Kim HE. Porous alumina ceramics with highly aligned pores by heat-treating extruded alumina/camphene body at temperature near its solidification point. J Eur Ceram Soc. 2012;32:1029-34. https://doi.org/10.1016/j.jeurceramsoc.2011.11.035
  36. Lei B, Shin KH, Noh DY, Jo IH, Koh YH, Choi YW, et al. Nanofibrous gelatin- silica hybrid scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J Mater Chem. 2012;22:14133-40. https://doi.org/10.1039/c2jm31290e

Cited by

  1. Preparation of Electrically Conductive Calcium Phosphate Composite Foams by Particle-Stabilized Emulsion Route vol.1, pp.2, 2018, https://doi.org/10.3390/ceramics1020025
  2. Micro- and Nanoparticulate Hydroxyapatite Powders as Fillers in Polyacrylate Bone Cement—A Comparative Study vol.13, pp.12, 2020, https://doi.org/10.3390/ma13122736