한국섬유공학회지 (Textile Science and Engineering)

  • 제52권1호
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  • Pages.14-19
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  • 2015
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  • 1225-1089(pISSN)
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  • 2288-6419(eISSN)
한국섬유공학회 (The Korean Fiber Society)
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전기방사를 이용한 경피 약물 전달 체계용 알지네이트 웹 제조

Preparation of Electrospun Alginate Webs for Transdermal Drug Delivery Systems

  • 구민경 (건국대학교 공과대학 섬유공학과) ;
  • 김창현 (건국대학교 공과대학 섬유공학과) ;
  • 김형섭 (건국대학교 공과대학 유기나노시스템공학과)
  • Ku, Min Kyung (Department of Textile Engineering, Konkuk University) ;
  • Kim, Changhyun (Department of Textile Engineering, Konkuk University) ;
  • Kim, Hyungsup (Department of Organic and Nano System Engineering, Konkuk University)
  • 투고 : 2014.12.17
  • 심사 : 2015.01.28
  • 발행 : 2015.02.28
⟨ 이전 논문 다음 논문 ⟩

초록

In this study, alginate was electrospun for transdermal drug delivery systems. The spinnability of alginate was improved by the reduction of intra-molecular hydrogen bonding using glycerol. The prepared alginate solutions were electrospun and coagulated in $CaCl_2$ aqueous solution for improved dimensional stability. To observe release ability, the electrospun alginate web was immersed in phosphate buffered saline (PBS) solution. Although 60% of dextran (drug model) was released from the prepared web within 30 minutes, the remaining drug was released continuously over 3 days. The results indicated that the prepared alginate web could be used as a transdermal drug delivery system.

키워드

참고문헌

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