Biomaterials and Biomechanics in Bioengineering

  • 제2권3호
  • /
  • Pages.127-141
  • /
  • 2015
  • /
  • 2465-9835(pISSN)
  • /
  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Modified Pharmacokinetic/Pharmacodynamic model for electrically activated silver-titanium implant system

  • Tan, Zhuo (Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University) ;
  • Orndorff, Paul E. (Department of Population Health and Pathobiology, North Carolina State University) ;
  • Shirwaiker, Rohan A. (Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University)
  • 투고 : 2015.05.09
  • 심사 : 2015.07.11
  • 발행 : 2015.09.25
⟨ 이전 논문 다음 논문 ⟩

초록

Silver-based systems activated by low intensity direct current continue to be investigated as an alternative antimicrobial for infection prophylaxis and treatment. However there has been limited research on the quantitative characterization of the antimicrobial efficacy of such systems. The objective of this study was to develop a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model providing the quantitative relationship between the critical system parameters and the degree of antimicrobial efficacy. First, time-kill curves were experimentally established for a strain of Staphylococcus aureus in a nutrientrich fluid environment over 48 hours. Based on these curves, a modified PK/PD model was developed with two components: a growing silver-susceptible bacterial population and a depreciating bactericidal process. The test of goodness-of-fit showed that the model was robust and had good predictability ($R^2>0.7$). The model demonstrated that the current intensity was positively correlated to the initial killing rate and the bactericidal fatigue rate of the system while the anode surface area was negatively correlated to the fatigue rate. The model also allowed the determination of the effective range of these two parameters within which the system has significant antimicrobial efficacy. In conclusion, the modified PK/PD model successfully described bacterial growth and killing kinetics when the bacteria were exposed to the electrically activated silver-titanium implant system. This modeling approach as well as the model itself can also potentially contribute to the development of optimal design strategies for other similar antimicrobial systems.

키워드

참고문헌

  1. Anima, Nanda and Saravanan, M. (2009), "Biosynthesis of silver nanoparticles from Staphylococcus aureus and its antimicrobial activity against MRSA and MRSE", Nanomed. Nanotech. Biol. Med., 5(4), 452-456. https://doi.org/10.1016/j.nano.2009.01.012
  2. Baranyi, J. and Roberts, T.A. (1994), "A dynamic approach to predicting bacterial growth in food", Int. J. Food Microbiol., 23(3), 277-294. https://doi.org/10.1016/0168-1605(94)90157-0
  3. Berbari, E., Hanssen, A., Duffy, M., Steckelberg, J., Ilstrup, D., Harmsen, W. and Osmon, D. (1998), "Risk factors for prosthetic joint infection: case-control study", Clin. Infect. Dis., 27(5), 1247-1254. https://doi.org/10.1086/514991
  4. Carlsson, L., Rostlund, T., Albrektsson, B., Albrektsson, T. and Branemark, P. (1986), "Osseointegration of titanium implants", Acta Orthop. Scand., 57(4), 285-289. https://doi.org/10.3109/17453678608994393
  5. Craig, W.A. (1995), "Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins", Diagn. Microbiol. Infect. Dis., 22(1), 89-96. https://doi.org/10.1016/0732-8893(95)00053-D
  6. Czock, D. and Keller, F. (2007), "Mechanism-based pharmacokinetic-pharmacodynamic modeling of antimicrobial drug effects", J. Pharmacokinet. Pharmacodyn., 34(6), 727-751. https://doi.org/10.1007/s10928-007-9069-x
  7. Darouiche, R.O. (1999), "Anti-infective efficacy of silver-coated medical prostheses", Clin. Infect. Dis., 29(6), 1371-1377. https://doi.org/10.1086/313561
  8. Derendorf, H. and Meibohm, B. (1999), "Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives", Pharm. Res., 16(2), 176-185. https://doi.org/10.1023/A:1011907920641
  9. Emsley, J. (2001). Nature's Building Blocks: An A-Z Guide to the Elements, Oxford, Oxford University Press.
  10. Feng, Q.L., Wu, J., Chen, G.Q., Cui, F.Z., Kim, T.N. and Kim, J.O. (2000), "A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus", J. Biomed. Mater. Res. A, 52(4), 662-668. https://doi.org/10.1002/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO;2-3
  11. Fuller, T.A., Wysk, R.A., Charumani, C., Kennett, M., Sebastiennelli, W.J., Abrahams, R., Shirwaiker, R.A., Voigt, R.C. and Royer, P. (2010), "Developing an engineered antimicrobial/prophylactic system using electrically activated bactericidal metals", J. Mater. Sci. Mater. Med., 21(7), 2103-2114. https://doi.org/10.1007/s10856-010-4071-z
  12. Gustafsson, I., Lowdin, E., Odenholt, I. and Cars, O. (2001), "Pharmacokinetic and pharmacodynamic parameters for antimicrobial effects of cefotaxime and amoxicillin in an in vitro kinetic model", Antimicrob. Agents Chemother., 45(9), 2436-2440. https://doi.org/10.1128/AAC.45.9.2436-2440.2001
  13. Harris Williams & Co. (2011), Orthopedic Implants-A Global Market Overview, Hyderabad, India, Industry Experts.
  14. Le Guehennec, L., Soueidan, A., Layrolle, P. and Amouriq, Y. (2007), "Surface treatments of titanium dental implants for rapid osseointegration", Dent. Mater., 23(7), 844-854. https://doi.org/10.1016/j.dental.2006.06.025
  15. Liu, P., Rand, K.H., Obermann, B. and Derendorf, H. (2005), "Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models", Int. J. Antimicrob. Agents, 25(2), 120-129. https://doi.org/10.1016/j.ijantimicag.2004.09.012
  16. Loh, J.V., Percival, S.L., Woods, E.J., Williams, N.J. and Cochrane, C.A. (2009), "Silver resistance in MRSA isolated from wound and nasal sources in humans and animals", Int. Wound J., 6(1), 32-38. https://doi.org/10.1111/j.1742-481X.2008.00563.x
  17. Marshall, S., Macintyre, F., James, I., Krams, M. and Jonsson, N.E. (2006), "Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development: a case study of a therapeutic protein", Clin. Pharmacokinet., 45(2), 177-197. https://doi.org/10.2165/00003088-200645020-00004
  18. Nielsen, E.I., Viberg, A., Lowdin, E., Cars, O., Karlsson, M.O. and Sandstrom, M. (2006), "Semimechanistic Pharmacokinetic/Pharmacodynamic model for assessment of activity of antibacterial agent from time-kill curve experiments", Antimicrob. Agents Chemother., 51(1), 128.
  19. Samberg, M.E., Tan, Z., Monteiro-Riviere, N.A., Orndorff, P.E. and Shirwaiker, R.A. (2013), "Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications", J. Mater. Sci. Mater. Med., 24(3), 755-760. https://doi.org/10.1007/s10856-012-4838-5
  20. Shirwaiker, R.A., Samberg, M.E., Cohen, P.H., Wysk, R.A. and Monteiro-Riviere, N.A. (2013), "Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices", WIREs Nanomed. Nanobiotechnol., 5(3), 191-204. https://doi.org/10.1002/wnan.1201
  21. Shirwaiker, R.A., Wysk, R.A., Kariyawasam, S., Carrion, H. and Voigt, R.C. (2011), "Micro-scale fabrication and characterization of a silver-polymer-based electrically activated antibacterial surface", Biofabrication, 3(1), 015003. https://doi.org/10.1088/1758-5082/3/1/015003
  22. Shirwaiker, R.A., Wysk, R.A., Kariyawasam, S., Voigt, R.C., Carrion, H. and Nembhard, H. (2014), "Interdigitated silver-polymer-based antibacterial surface system activated by oligodynamic iontophoresis - An empirical characterization study", Biomed. Microdevices, 16(1), 1-10. https://doi.org/10.1007/s10544-013-9800-x
  23. Strohala, R., Schellingb, M., Takacsc, M., Jureckac, W., Gruberd, U. and Offner, F. (2005), "Nanocrystalline silver dressings as an efficient anti-MRSA barrier: a new solution to an increasing problem", J. Hosp. Infect., 60(3), 226-230. https://doi.org/10.1016/j.jhin.2005.04.001
  24. Tan, Z., Ganapathy, A., Orndorff, P.E. and Shirwaiker, R.A. (2015), "Effects of cathode design parameters on in vitro antimicrobial efficacy of electrically-activated silver-based iontophoretic system", J. Mater. Sci. Mater. Med., 26(1), 1-10.
  25. Tan, Z., Xu, G. and Shirwaiker, R.A. (2014), "In vitro quantitative analysis on the antimicrobial performance of the dual-metal implant system", IIE Annual Conference and Expo, Montreal.
  26. Tsvetkov, V.V. (1995), "Corrosion-resistant titanium alloys", Pharm. Chem. J., 29(8), 564-566. https://doi.org/10.1007/BF02219016
  27. Vaddady, P.K., Lee, R.E. and Meibohm, B. (2010), "In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB", Future Med. Chem., 2(8), 1355-1369. https://doi.org/10.4155/fmc.10.224
  28. Virk, A. and Osmon, D. (2001), "Prosthetic joint infection", Curr. Treat Option. Infect Dis., 351(16), 287-300.
  29. Wang, Z., Butner, J.D., Cristini, V. and Deisboeck, T.S. (2015), "Integrated PK-PD and agent-based modeling in oncology", J. Pharmacokinet. Pharmacodyn., doi:10.1007/s10928-015-9403-7.
  30. Wiedel, J. (2002), "Salvage of infected total knee fusion: the last option", Clin. Orthop. Relat. Res., 404, 139-142. https://doi.org/10.1097/00003086-200211000-00024
  31. Wysk, R.A., Sebastianelli, W.J., Shirwaiker, R.A., Bailey, G.M., Charumani, C., Kennett, M., Kaucher, A., Abrahams, R., Fuller, T.A., Royer, P., Voigt, R.C. and Cohen, P.H. (2010), "Prophylactic bactericidal orthopedic implants - animal testing study", J. Biomed. Sci. Eng., 3(9), 917-926. https://doi.org/10.4236/jbise.2010.39122

피인용 문헌

  1. The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis pp.2199-4757, 2019, https://doi.org/10.1007/s40846-018-0447-1