Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Respiratory Syncytial Virus Outbreak in the Basic Military Training Camp of the Republic of Korea Air Force

  • Park, Won-Ju (Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital) ;
  • Yoo, Seok-Ju (Aerospace Medical Research Center, Republic of Korea Air Force) ;
  • Lee, Suk-Ho (Aerospace Medical Research Center, Republic of Korea Air Force) ;
  • Chung, Jae-Woo (Department of Laboratory Medicine, Dongguk University Ilsan Hospital) ;
  • Jang, Keun-Ho (Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital) ;
  • Moon, Jai-Dong (Department of Occupational and Environmental Medicine, Chonnam National University Hwasun Hospital)
  • Received : 2014.08.20
  • Accepted : 2014.11.07
  • Published : 2015.01.31
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Abstract

Objectives: An outbreak of acute febrile illness occurred in the Republic of Korea Air Force boot camp from May to July 2011. An epidemiological investigation of the causative agent, which was of a highly infective nature, was conducted. Methods: Throat swabs were carried out and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) assay was performed to identify possible causative factors. Results: The mean age of patients who had febrile illness during the study period was 20.24 years. The multiplex RT-PCR assay identified respiratory syncytial virus (RSV) as the causative agent. The main symptoms were sore throat (76.0%), sputum (72.8%), cough (72.1%), tonsillar hypertrophy (67.9%), and rhinorrhea (55.9%). The mean temperature was $38.75^{\circ}C$ and the attack rate among the recruits was 15.7% (588 out of 3750 recruits), while the mean duration of fever was 2.3 days. The prognosis was generally favorable with supportive care but recurrent fever occurred in 10.1% of the patients within a month. Conclusions: This is the first epidemiological study of an RSV outbreak that developed in a healthy young adult group. In the event of an outbreak of an acute febrile illness of a highly infective nature in facilities used by a young adult group, RSV should be considered among the possible causative agents.

Keywords

References

  1. Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microvirology. 4th ed. St. Louis: Mosby; 2002, p. 532-533.
  2. Parveen S, Broor S, Kapoor SK, Fowler K, Sullender WM. Genetic diversity among respiratory syncytial viruses that have caused repeated infections in children from rural India. J Med Virol 2006;78(5):659-665. https://doi.org/10.1002/jmv.20590
  3. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009;360(6):588-598. https://doi.org/10.1056/NEJMoa0804877
  4. Park WJ. Seroprevalence of respiratory syncytial virus IgG among healthy young adults in basic training for the Republic of Korea Air Force. J Korean Med Sci 2014;29(9):1325-1327. https://doi.org/10.3346/jkms.2014.29.9.1325
  5. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003;289(2): 179-186. https://doi.org/10.1001/jama.289.2.179
  6. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010;375(9725):1545-1555. https://doi.org/10.1016/S0140-6736(10)60206-1
  7. Dowell SF, Anderson LJ, Gary HE Jr, Erdman DD, Plouffe JF, File TM Jr, et al. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis 1996;174(3):456-462. https://doi.org/10.1093/infdis/174.3.456
  8. O'Shea MK, Ryan MA, Hawksworth AW, Alsip BJ, Gray GC. Symptomatic respiratory syncytial virus infection in previously healthy young adults living in a crowded military environment. Clin Infect Dis 2005;41(3):311-317. https://doi.org/10.1086/431591
  9. O'Shea MK, Pipkin C, Cane PA, Gray GC. Respiratory syncytial virus: an important cause of acute respiratory illness among young adults undergoing military training. Influenza Other Respir Viruses 2007;1(5-6):193-197. https://doi.org/10.1111/j.1750-2659.2007.00029.x
  10. Falsey AR, Formica MA, Hennessey PA, Criddle MM, Sullender WM, Walsh EE. Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;173(6):639-643. https://doi.org/10.1164/rccm.200510-1681OC
  11. Terrosi C, Di Genova G, Martorelli B, Valentini M, Cusi MG. Humoral immunity to respiratory syncytial virus in young and elderly adults. Epidemiol Infect 2009;137(12):1684-1686. https://doi.org/10.1017/S0950268809002593
  12. Murata Y, Falsey AR. RSV infection in elderly adults. In: Cane P, editor. Respiratory syncytial virus. Vol. 14. Amsterdam: Elsevier; 2007, p. 163-176.
  13. Walsh EE, Falsey AR. Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets 2012;12(2):98-102. https://doi.org/10.2174/187152612800100116
  14. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001;344(25):1917-1928. https://doi.org/10.1056/NEJM200106213442507
  15. Kim CK, Choi J, Callaway Z, Kim HB, Chung JY, Koh YY, et al. Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul, Korea, 2003-2008. J Korean Med Sci 2010;25(3):342-347. https://doi.org/10.3346/jkms.2010.25.3.342
  16. Colosia AD, Masaquel A, Hall CB, Barrett AM, Mahadevia PJ, Yogev R. Residential crowding and severe respiratory syncytial virus disease among infants and young children: a systematic literature review. BMC Infect Dis 2012;12:95. https://doi.org/10.1186/1471-2334-12-95
  17. Gray GC, Callahan JD, Hawksworth AW, Fisher CA, Gaydos JC. Respiratory diseases among U.S. military personnel: countering emerging threats. Emerg Infect Dis 1999;5(3):379-385. https://doi.org/10.3201/eid0503.990308
  18. Fraire AE, Woda BA, Welsh RM, Kradin RL. Viruses and the lung: infections and non-infectious viral-linked lung disorders. Heidelberg: Springer; 2014, p. 95-99.
  19. Centers for Disease Control and Prevention. Brief report: respiratory syncytial virus infection. Frequently asked questions [cited 2014 Oct 8]. Available from: http://www.cdc.gov/rsv/about/faq.html.
  20. Agius G, Dindinaud G, Biggar RJ, Peyre R, Vaillant V, Ranger S, et al. An epidemic of respiratory syncytial virus in elderly people: clinical and serological findings. J Med Virol 1990;30(2): 117-127. https://doi.org/10.1002/jmv.1890300208
  21. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis 2001; 33(6):792-796. https://doi.org/10.1086/322657
  22. Xiang Z, Gonzalez R, Ren L, Xiao Y, Chen L, Zhang J, et al. Prevalence and clinical characteristics of human respiratory syncytial virus in Chinese adults with acute respiratory tract infection. J Med Virol 2013;85(2):348-353. https://doi.org/10.1002/jmv.23467
  23. Hurwitz JL. Respiratory syncytial virus vaccine development. Expert Rev Vaccines 2011;10(10):1415-1433. https://doi.org/10.1586/erv.11.120
  24. Krilov LR. Respiratory syncytial virus disease: update on treatment and prevention. Expert Rev Anti Infect Ther 2011;9(1): 27-32. https://doi.org/10.1586/eri.10.140
  25. Wright M, Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr Pulmonol 2011;46(4):324-347. https://doi.org/10.1002/ppul.21377
  26. Hynicka LM, Ensor CR. Prophylaxis and treatment of respiratory syncytial virus in adult immunocompromised patients. Ann Pharmacother 2012;46(4):558-566. https://doi.org/10.1345/aph.1Q553
  27. Trei JS, Johns NM, Garner JL, Noel LB, Ortman BV, Ensz KL, et al. Spread of adenovirus to geographically dispersed military installations, May-October 2007. Emerg Infect Dis 2010;16(5): 769-775. https://doi.org/10.3201/eid1605.091633

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