Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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A Study on Inhibitory Activities on Carbohydrase and Anti-Inflammatory Activities of Hot-Water and Ethanol Extracts from Immature Dried Bitter Melon (Momordica charantia L.)

미숙과 건여주(Momordica charantia L.) 열수 및 에탄올 추출물의 탄수화물 분해효소 저해 활성 및 항염증 활성에 대한 연구

  • Nam, Seung-Woo (Dept. of Food Science and Nutrition, Kyungpook National University) ;
  • Kim, Meera (Dept. of Food Science and Nutrition, Kyungpook National University)
  • 남승우 (경북대학교 식품영양학과) ;
  • 김미라 (경북대학교 식품영양학과)
  • Received : 2015.09.24
  • Accepted : 2015.11.04
  • Published : 2015.12.31
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Abstract

Bitter melon (Momordica charantia L.) has been used as a medicinal plant due to its biological activity. This study investigated the inhibitory effects on carbohydrase and anti-inflammatory effects of hot-water extract (WEM) and ethanol extract (EEM) from dried bitter melon cultivated in Korea. The inhibitory activities of EEM against ${\alpha}$-amylase and ${\alpha}$-glucosidase were over 70% at 4,000 ppm. The inhibitory activities of EEM were significantly higher than those of WEM at all concentrations. The anti-inflammatory effects were evaluated by measuring nitric oxide (NO) production in LPS-stimulated RAW264.7 cells. EEM did not show cytotoxicity on RAW264.7 cells at the test concentrations. Moreover, the inhibitory effect on NO production in LPS-stimulated RAW264.7 cells was significantly increased by the addition of EEM. These findings suggest that EEM has good inhibitory effect on carbohydrase and anti-inflammatory activity and it has potential as a source of natural functional material.

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References

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