Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Current Status of Biomedical Applications using 3D Printing Technology

3D프린팅 활용 생체의료분야 기술동향

  • Park, Suk-Hee (Micro/Nano Scale Manufacturing R&BD Group, Korea Institute of Industrial Technology) ;
  • Park, Jean Ho (Micro/Nano Scale Manufacturing R&BD Group, Korea Institute of Industrial Technology) ;
  • Lee, Hye Jin (Micro/Nano Scale Manufacturing R&BD Group, Korea Institute of Industrial Technology) ;
  • Lee, Nak Kyu (Micro/Nano Scale Manufacturing R&BD Group, Korea Institute of Industrial Technology)
  • 박석희 (한국생산기술연구원 마이크로나노공정연구실용화그룹) ;
  • 박진호 (한국생산기술연구원 마이크로나노공정연구실용화그룹) ;
  • 이혜진 (한국생산기술연구원 마이크로나노공정연구실용화그룹) ;
  • 이낙규 (한국생산기술연구원 마이크로나노공정연구실용화그룹)
  • Received : 2014.09.23
  • Accepted : 2014.11.17
  • Published : 2014.12.01
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Abstract

To date, biomedical application of three-dimensional (3D) printing technology remains one of the most important research topics and business targets. A wide range of approaches have been attempted using various 3D printing systems with general materials and specific biomaterials. In this review, we provide a brief overview of the biomedical applications using 3D printing techniques, such as surgical tool, medical device, prosthesis, and tissue engineering scaffold. Compared to the other applications of 3D printed products, the scaffold fabrication should be performed with careful selection of bio-functional materials. In particular, we describe how the biomaterials can be processed into 3D printed scaffold and applied to tissue engineering area.

Keywords

References

  1. Ahn, D. G. and Yang, D. Y., "Principle of Rapid Prototyping and its Trends," J. Korean Soc. Precis. Eng., Vol. 22, No. 10, pp. 7-16, 2005.
  2. Wohler, T., "Wohlers Report 2013," Wohler's Associates Inc., pp. 23-52, 2013.
  3. Zein, I., Hutmacher, D. W., Tan, K. C., and Teoh, S. H., "Fused Deposition Modeling of Novel Scaffold Architectures for Tissue Engineering Applications," Biomaterials, Vol. 23, No. 4, pp. 1169-1185, 2002. https://doi.org/10.1016/S0142-9612(01)00232-0
  4. EOS, "Medical Devices," http://www.eos.info/industries_markets/medical/medical_devices (Accessed 12 NOV. 2014)
  5. 3ders, "Ivan Owen: Life Enhancing 3D printed Prosthetics," http://www.3ders.org/articles/20140125- ivan-owen-life-enhancing-prosthetics-3d-printed-andopen-sourced.html (Accessed 12 NOV. 2014)
  6. Lee, J. Y., Choi, B., Wu, B., and Lee, M., "Customized Biomimetic Scaffolds Created by Indirect Three-dimensional Printing for Tissue Engineering," Biofabrication, Vol. 5, No. 4, Paper No. 045003, 2013.
  7. Stratasys, "Medical Case Studies," http://www.stratasys.co.kr/resources/case-studies/medical (Accessed 12 NOV. 2014)
  8. Turkcadcam, "Rapid Prototyping Helps Separate Conjoined Twins," http://www.turkcadcam.net/rapor/ otoinsa/uyg-medikal-conjoined-twins.html (Accessed 12 NOV. 2014)
  9. Cnet, "3D-printed 'Magic Arms' Give Little Girl New Reach," http://www.cnet.com/news/3d-printed-magicarms-give-little-girl-new-reach/ (Accessed 12 NOV. 2014)
  10. Kitson, P. J., Rosnes, M. H., Sans, V., Dragone, V., and Cronin, L., "Configurable 3D-Printed Millifluidic and Microfluidic 'Lab on a Chip' Reactionware Devices," Lab on a Chip, Vol. 12, No. 18, pp. 3199- 3522, 2012. https://doi.org/10.1039/c2lc90088b
  11. Huang, M. C., Ye, H., Kuan, Y. K., Li, M. H., and Ying, J. Y., "Integrated Two-step Gene Synthesis in a Microfluidic Device," Lab on a Chip, Vol. 9, No. 2, pp. 276-285, 2009. https://doi.org/10.1039/b807688j
  12. Yoo, J. J. and Lee, I. W, "Regenerative Medicine," Koonja Publishing Inc., pp. 293-508, 2010.
  13. EOS, "Orthopaedic Technology," http://www.eos.info/industries_markets/medical/orthopaedic_technology (Accessed 12 NOV. 2014)
  14. Realizer, "SLM in Action," http://www.goldenprogress.com/milling/realizer-slm-in-action.shtml (Accessed 12 NOV. 2014)
  15. Conept Laser, "Implants and Medical Instruments with LaserCUSING," http://www.concept-laser.de/ en/industry/medical.html (Accessed 12 NOV. 2014)
  16. Griffith, L. G. and Naughton, G., "Tissue Engineering: Current Challenges and Expanding Opportunities," Science, Vol. 295, No. 8, pp. 1009-1016, 2002. https://doi.org/10.1126/science.1069210
  17. Mikos, A. G. and Temenoff, J. S., "Formation of Highly Porous Biodegradable Scaffolds for Tissue Engineering," Electron. J. Biotechnol., Vol. 3, No. 2, pp. 114-119, 2000.
  18. Hollister S. J., "Porous Scaffold Design for Tissue Engineering," Nat. Mater., Vol. 4, No. 7, pp. 518-524, 2005. https://doi.org/10.1038/nmat1421
  19. 3D Biotek, "3D Insert : Proven & Superior 3D Architecture for in vivo-like 3D Culture," http://www.3dbiotek.com/newsletters/2012/Newsletter201212_2_Web.html (Accessed 12 NOV. 2014)
  20. Lee, S. J. and Cho, D. W., "Solid Freeform Fabrication Technique in Tissue Engineering," J. Korean Soc. Precis. Eng., Vol. 23, No. 12, pp. 7-15, 2006.
  21. Park, S. H., Kim, T. G., Kim, H. C., Yang, D. Y., and Park, T. G., "Development of Dual Scale Scaffolds via Direct Polymer Melt Deposition and Electrospinning for Applications in Tissue Regeneration," Acta Biomater., Vol. 4, No. 5, pp. 1198-1207, 2008. https://doi.org/10.1016/j.actbio.2008.03.019
  22. Kwon, I. K. and Matsuda, T., "Photo-polymerized Microarchitectural Constructs Prepared by Microstereolithography ($\mu$SL) using Liquid Acrylateend-capped Trimethylene Carbonate-based Prepolymers," Biomaterials, Vol. 26, No. 14, pp. 1675-1684, 2005. https://doi.org/10.1016/j.biomaterials.2004.06.041
  23. Lee, J. W., Ahn, G. S., Kim, D. S., and Cho, D. W., "Development of Nano- and Microscale Composite 3D Scaffolds using PPF/DEF-HA and Microstereolithography," Microelectron. Eng., Vol. 86, No. No. 4, pp. 1465-1467, 2009. https://doi.org/10.1016/j.mee.2008.12.038
  24. Kim, T. G., Park, S. H., Chung, H. J., Yang, D. Y., and Park, T. G., "Microstructured Scaffold Coated with Hydroxyapatite/Collagen Nanocomposite Multilayer for Enhanced Osteogenic Induction of Human Mesenchymal Stem Cells," J. Mater. Chem., Vol. 20, No. 40, pp. 8927-8933, 2010. https://doi.org/10.1039/c0jm01062f
  25. Seyednejad, H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., et al., "In vivo Biocompatibility and Biodegradation of 3D-Printed Porous Scaffolds Based on a Hydroxyl-functionalized Poly($\varepsilon$-caprolactone)," Biomaterials, Vol. 33, No. 17, pp. 4309-4318, 2012. https://doi.org/10.1016/j.biomaterials.2012.03.002
  26. Ding, C., Qiao, Z., Jiang, W., Li, H., Wei, J., et al., "Regeneration of a Goat Femoral Head Using a Tissue-specific, Biphasic Scaffold Fabricated with CAD/CAM Technology," Biomaterials, Vol. 34, No. 28, pp. 6706-6716, 2013. https://doi.org/10.1016/j.biomaterials.2013.05.038
  27. Kim, H. N., Kang, D. H., Kim, M. S., Jiao, A., Kim, D. H., and Suh, K. Y., "Patterning Methods for Polymers in Cell and Tissue Engineering," Ann. Biomed. Eng., Vol. 40, No. 6, pp. 1339-1355, 2012. https://doi.org/10.1007/s10439-012-0510-y
  28. Hockaday, L. A., Kang, K. H., Colangelo, N. W., Cheung, P. Y., Duan, B., et al., "Rapid 3D Printing of Anatomically Accurate and Mechanically Heterogeneous Aortic Valve Hydrogel Scaffolds," Biofabrication, Vol. 4, No. 3, Paper No. 035005, 2012.
  29. Pataky, K., Braschler, T., Negro, A., Renaud, P., Lutolf, M. P., and Brugger, J., "Microdrop Printing of Hydrogel Bioinks into 3D Tissue-Like Geometries," Adv. Mater., Vol. 24, No. 3, pp. 391-396, 2012. https://doi.org/10.1002/adma.201102800
  30. Yan, J., Huang, Y., and Chrisey, D. B., "Laser-assisted Printing of Alginate Long Tubes and Annular Constructs," Biofabrication, Vol. 5, No. 1, Paper No. 015002, 2013.
  31. Park, S. H., Koh, U. H., Kim, M., Yang, D. Y., Suh, K. Y., and Shin, J. H., "Hierarchical Multilayer Assembly of an Ordered Nanofibrous Scaffold via Theramal Fusion Bonding," Biofabrication, Vol. 6, No. 2, Paper No. 024107, 2014.
  32. Ahn, S., Lee, H., Bonassar, L. J., and Kim, G., "Cells (MC3T3-E1)-laden Alginate Scaffolds Fabricated by a Modified Solid-Freeform Fabrication Process Supplemented with an Aerosol Spraying," Biomacromolecules, Vol. 13, No. 9, pp. 2997-3003, 2012. https://doi.org/10.1021/bm3011352
  33. Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D. H., et al., "Rapid Casting of Patterned Vascular Networks for Perfusable Engineered Three-dimensional Tissues," Nat. Mater., Vol. 11, No. 9, pp. 768-774, 2012. https://doi.org/10.1038/nmat3357
  34. Norotte, C., Marga, F. S., Niklason, L. E., and Forgacs, G., "Scaffold-free Vascular Tissue Engineering using Bioprinting," Biomaterials, Vol. 30, No. 30, pp. 5910-5917, 2009. https://doi.org/10.1016/j.biomaterials.2009.06.034
  35. Mannoor, M. S., Jiang, Z., James, T., Kong, Y. L., Malatesta, K. A., et al., "3D Printed Bionic Ears," Nano Lett., Vol. 13, No. 6, pp. 2634-2639, 2013. https://doi.org/10.1021/nl4007744

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